Compounds as modulators of ROR gamma
The present invention encompasses compounds of the formula (I) wherein the variables are defined herein which are suitable for the modulation of RORγ and the treatment of diseases related to the modulation of RORγ. The present invention also encompasses processes of making compounds of formula (I) and pharmaceutical preparations containing them.
1. A compound of formula I
wherein:
R 2′ is H; and
R 1 and R 2 are independently selected from benzothiophen-3-yl, isoquinolinyl, [1,2,4]-oxadiazolyl, phenyl, pyrazolyl, pyridyl, thiazolyl, 1H-[1,2,4]triazolyl and 2H-[1,2,3]triazolyl, wherein when R 1 is phenyl, then R 2 is other than phenyl;
or
R 2 and R 2′ form a spiro benzofuran-3-one ring; and
R 1 is selected from C 1-6 alkyl, benzothiophen-3-yl, isoquinolinyl, [],2,41-oxadiazolyl, phenyl, pyrazolyl, pyridyl, thiazolyl, 1H-[1,2,4]triazolyl and 2H-[1,2,3]triazolyl;
wherein R 1 and R 2 are each optionally substituted by one to two groups independently selected from C 1-4 alkyl, C 3-5 cycloalkyl, cyclopropylmethyl, —CF 3 , halogen, —OCF 3 , —OH, -OCH 3 and phenyl;
R 3 is selected from phenyl, pyridyl and pyrimidinyl;
wherein R 3 is substituted with a group selected from —SO 2 C 1-3 alkyl and —SO 2 NHC 1-3 alkyl;
or an enantiomer or a salt thereof.
2. The compound of formula (I) according to claim 1 , wherein R 2′ is H; and
R 1 and R 2 are independently selected from benzothiophen-3-yl, isoquinolin-5-yl, [1,2,4]-oxadiazol-5-yl, phenyl, 4- and 5-pyrazolyl, 2- and 3-pyridyl, thiazol-2-yl, 1H-[1,2,4]triazol-5-yl and 2H-[1,2,3]triazol-5-yl, wherein when R 1 is phenyl, then R 2 is other than phenyl;
or
R 2 and R 2′ may form a spiro benzofuran-3-one ring; and
R 1 is selected from isopropyl, benzothiophen-3-yl, isoquinolin-5-yl, [1,2,41]-oxadiazol-5-yl, phenyl, 4- and 5-pyrazolyl, 2- and 3-pyridyl, thiazol-2-yl, 1H-[1,2,4]triazol-5-yl and 2H-[1,2,3]triazol-5-yl;
R 1 and R 2 are each optionally substituted by one to two groups independently selected from C 1-4 alkyl, C 3-5 cycloalkyl, cyclopropylmethyl, —CF 3 , Cl, —OCF 3 , —OH, -OCH 3 and phenyl;
R 3 is selected from phenyl, 2- and 3-pyridyl and 2-pyrimidinyl;
wherein R 3 is substituted with a group selected from —SO 2 CH 2 CH 3 and —SO 2 NHCH 3 ;
or an enantiomer or a salt thereof.
3. The compound of formula (I) according to claim 1 , wherein R 2′ is H; and
R 1 and R 2 are independently selected from benzothiophen-3-yl, isoquinolin-5-yl, phenyl, 4- and 5-pyrazolyl, 2-pyridyl and 1H-[1,2,4]triazol-5-yl, wherein when R 1 is phenyl, then R 2 other than phenyl;
or
R 2 and R 2′ may form a spiro benzofuran-3-one ring; and
R 1 is selected from isopropyl, benzothiophen-3-yl, isoquinolin-5-yl, phenyl, 4- and 5-pyrazolyl, 2-pyridyl and 1H-[1,2,4]triazol-5-yl;
wherein R 1 and R 2 are each optionally substituted by one to two groups independently selected from C 1-4 alkyl, C 3-5 cycloalkyl, cyclopropylmethyl, —CF 3 , Cl, —OCF 3 ,—OH and -OCH 3 ;
R 3 is selected from phenyl and 2-pyridyl;
wherein R 3 is substituted with a group selected from —SO 2 CH 2 CH 3 and —SO 2 NHCH 3 ;
or an enantiomer or a salt thereof.
4. The compound of formula (I) according to claim 1 , wherein R 2′ is H; and
R 1 and R 2 are independently selected from isopropyl, phenyl, 4- and 5-pyrazolyl and 2-pyridyl, wherein when R 1 is phenyl, then R 2 is other than phenyl;
or
R 2 and R 2′ may form a spiro benzofuran-3-one ring; and
R 1 is selected from isopropyl and phenyl;
wherein R 1 and R 2 are each optionally substituted by one to two groups independently selected from methyl, isopropyl, tert-butyl, cyclopropyl, cyclopentyl, —CF 3 , Cl and —OCF3;
R 3 is selected from phenyl and 2-pyridyl;
wherein R 3 is substituted with a group selected from —SO 2 CH 2 CH 3 and —SO 2 NHCH 3 ;
or an enantiomer or a salt thereof.
5. The compound according to claim 1 selected from the group consisting of
the enantiomers thereof and the pharmaceutically acceptable salts thereof.
6. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable excipient or carrier.
7. A method for treating an autoimmune disease or allergic disorder in a patient comprising administering to said patient a therapeutically effective amount of a compound of formula (I) according to claim 1 , or a pharmaceutically acceptable salt thereof.
8. The method according to claim 7 , wherein the autoimmune disease or allergic disorder is selected from rheumatoid arthritis, psoriasis, systemic lupus erythromatosis, lupus nephritis, scleroderma, asthma, allergic rhinitis, allergic eczema, multiple sclerosis, juvenile rheumatoid arthritis, juvenile idiopathic arthritis, type I diabetes, inflammatory bowel disease, graft versus host disease, psoriatic arthritis, reactive arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, uveitis and non-radiographic spondyloarthropathy.