Patent
Provided is a method of treating or preventing pneumococcal disease. Also provided is a method of diagnosing pneumococcal disease.
1. A method of treating a disease caused by Streptococcus pneumoniae , comprising: administering a therapeutically effective amount of a Streptococcus pneumonia putative segregation and condensation protein B (ScpB) or a formulation comprising the ScpB protein to a subject in need thereof.
2. The method according to claim 1 , wherein the disease caused by the Streptococcus pneumoniae comprises pneumonia, meningitis, or sepsis.
3. The method according to claim 1 , comprising:
administering the ScpB protein from Streptococcus pneumoniae in combination with an a capsular polysaccharide protein.
4. The method according to claim 1 , wherein the ScpB protein from Streptococcus pneumoniae is administered to the subject subcutaneously.
5. The method according to claim 1 . wherein the ScpB protein from Streptococcus pneumoniae is administered to the subject at least one time.
6. The method according to claim 5 , wherein the ScpB protein from Streptococcus pneumoniae is administered to the subject three times.
7. The method according to claim 6 , wherein the ScpB protein from Streptococcus pneumoniae is administered to the subject three times at an interval of 14 days.
8. The method according to claim 1 , wherein the subject is a mammal selected from a human, a mouse, a dog, a monkey, a sheep, a pig, a rabbit, and a camel.
9. The method according to claim 1 , wherein the formulation further comprises a pharmaceutically acceptable adjuvant.
10. The method of claim 1 , wherein the disease caused by the Streptococcus pneumoniae is sepsis.