Nicotine particle capsule

1. A capsule containing particles comprising nicotine salt and having a mass median aerodynamic diameter from about 0.5 micrometers to about 4 micrometers, and particles comprising flavor and having a mass median aerodynamic diameter from 50 micrometers to 150 micrometers, the capsule defining an internal volume,

wherein only a single aperture having a diameter from about 0.5 mm to about 1.5 mm extends through the capsule and is sized to provide a fraction amount of the particles comprising nicotine salt and the particles comprising flavor, at conventional smoking regime air flow rates of less than about 5 L/min once a piercing element used to form the single aperture is withdrawn from the single aperture.

2. The capsule according to claim 1 , wherein the ratio of the diameter of the single aperture to the mass median aerodynamic diameter of the particles comprising nicotine is from about 200 to about 800.

3. The capsule according to claim 1 , wherein the particles comprising nicotine salt comprise an amino acid.

4. The capsule according to claim 1 , wherein the single aperture has an open surface area of from about 0.2 mm 2 to about 1 mm 2 .

5. The capsule according to claim 1 , wherein the internal volume of the capsule is from about 0.2 ml to about 0.45 ml.

6. The capsule according to claim 1 , wherein the single aperture has an open surface area in a range from about 0.7 mm 2 to about 7 mm 2 per ml of internal volume of the capsule.

7. The capsule according to claim 1 , wherein the capsule contains from about 10 mg to about 200 mg of dry powder.

8. The capsule according to claim 1 , wherein the single aperture is incident with a longitudinal axis of the capsule.

9. A dry powder inhaler comprising a capsule according to claim 1 .

10. The dry powder inhaler according to claim 9 , wherein the capsule is disposed in a capsule cavity configured to allow the capsule to rotate with stability within the capsule cavity.

11. The capsule according to claim 1 , wherein the particles comprising nicotine comprise leucine or L-leucine.

12. The capsule according to claim 2 , wherein the particles comprising nicotine comprise leucine or L-leucine.

13. The capsule according to claim 1 , wherein the nicotine comprises nicotine salt comprises nicotine pyruvate, nicotine citrate, nicotine aspartate, nicotine lactate, nicotine bitartrate, nicotine salicylate, nicotine fumarate, nicotine monopyruvate, or nicotine glutamate.

14. A dry powder inhaler comprising a capsule according to claim 12 .

15. A capsule containing particles comprising nicotine salt and particles comprising flavor, the capsule defining an internal volume,

wherein only a single aperture extends through the capsule and is sized to provide a fraction amount of the particles comprising nicotine salt and the particles comprising flavor during an inhalation at conventional smoking regime air flow rates of less than about 5 L/min once a piercing element used to form the single aperture is withdrawn from the single aperture, the capsule providing from 5 to 10 inhalations of 0.1 mg to 3 mg nicotine particles per inhalation,

the particles comprising nicotine having a mass median aerodynamic diameter from about 0.5 micrometers to about 4 micrometers and the particles comprising flavor having a mass median aerodynamic diameter from 50 micrometers to 150 micrometers.

16. The capsule of claim 15 , wherein the nicotine salt comprises nicotine pyruvate, nicotine citrate, nicotine aspartate, nicotine lactate, nicotine bitartrate, nicotine salicylate, nicotine fumarate, nicotine monopyruvate, or nicotine glutamate.