Use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases
The present invention refers to the use of protein kinase inhibitors and more specifically to the use of inhibitors of the protein kinase c-Jun amino terminal kinase, JNK inhibitor (poly-)peptides, chimeric peptides, or of nucleic acids encoding same as well as pharmaceutical compositions containing same, for the treatment of non-chronic or chronic inflammatory eye diseases, such as inflammatory diseases of the blephara, conjunctiva, cornea, sclera, the vitreous body, uvea, ciliary body, choroid, orbital bone, lacrimal gland, or iris, in particular wherein the inflammatory disease is selected from hordeolum, chalazion, conjunktivitis, keratitis, scieritis, episcleritis, endophthalmitis, panophtalmitis, irititis, uveitis, cyclitis, chorioiditis, orbital phlegmon, and myositis of the eye muscle etc.
1. A method for treating a chronic or non-chronic inflammatory eye disease in a subject in need thereof, the method comprising administering a JNK inhibitor (poly-) peptide comprising less than 150 amino acids in length to the subject, wherein the chronic or non-chronic inflammatory eye disease is selected from the group consisting of posterior uveitis, an inflammatory eye disease of the blephera, an inflammatory eye disease of the conjunctiva, an an inflammatory eye disease of the sclera, an inflammatory eye disease of the vitreous body, and an inflammatory eye disease of the orbital bone.
2. The method of claim 1 , wherein the JNK inhibitor (poly-)peptide comprises SEQ ID NO: 11.