Oral drug dosage form comprising drug in the form of nanoparticles
The present disclosure provides a stable solid pharmaceutical dosage form for oral administration. The dosage form includes a substrate that forms at least one compartment and a drug content loaded into the compartment. The dosage form is so designed that the active pharmaceutical ingredient of the drug content is released in a controlled manner.
1. A method of preparing a table comprising a plurality of layers, wherein each layer comprises a substrate, and wherein the tablet comprises a drug in the form of nanoparticles disposed between at least two of the plurality of layers, the method comprises:
a) printing a first layer by three-dimensional (3D) printing;
b) atomizing or spraying atop of the first layer a solution comprising the drug to form a plurality of nanoparticles on top of the first layer; and
c) printing a second layer by 3D printing.
2. The method of claim 1 , wherein the tablet comprises at least three layers, wherein the tablet comprises a first and a second drug in the form of nanoparticles disposed between the at least three of the plurality of layers, and wherein the method comprises:
a) printing a first layer by 3D printing;
b) atomizing or spraying atop of the first layer a solution comprising the first drug to form a plurality of nanoparticles on top of the first layer;
c) printing a second layer by 3D printing;
d) atomizing or spraying atop of the second layer a solution comprising the second drug to form a plurality of nanoparticles on top of the second layer; and
e) printing a third layer by 3D printing.
3. The method of claim 2 , wherein the first drug and the second drug are different.
4. The method of claim 2 , wherein the first drug and the second drug are the same.
5. The method of claim 1 , further comprising mixing the drug with the solution in which the drug is either dissolved or suspended before step b).
6. The method of claim 1 , further comprising drying the solution comprising the drug after atomizing or spraying the solution comprising the drug atop of the first layer.
7. The method of claim 1 , wherein the substrate is erodible.
8. The method of claim 1 , wherein the substrate comprises a drug embedded therein.
9. The method of claim 8 , wherein the drug embedded within the substrate of each layer is different.
10. The method of claim 8 , wherein the drug embedded within the substrate of each layer is the same.
11. The method of claim 1 , wherein the substrate thickness is different among each layer.
12. The method of claim 1 , wherein the substrate thickness is the same among each layer.
13. The method of claim 1 , wherein the size of the nanoparticles is from about 1 nm to about 900 nm.
14. The method of claim 1 , wherein the size of the nanoparticles is from about 100 nm to about 500 nm.
15. The method of claim 1 , wherein the size of the nanoparticles is from about 100 nm to about 200 nm.