Isoflavonoid compositions and methods for the treatment of cancer
Provided herein is a pharmaceutical composition comprising an isoflavonoid derivative and a cyclodextrin. Also provided herein are methods of treating cancer, sensitizing cancer cells, and inducing apoptosis in cancer cells by administering such compositions. In specific instances, provided herein are intravenous compositions and therapies.
1. A method of treating breast cancer in an individual in need, the method comprising administering to the individual a composition comprising: i) d-cis-3-(4-hydroxyphenyl)-4-(4-hydroxyphenyl)-8-methylchroman-7-ol provided in at least 90% enantiomeric excess and ii) a cyclodextrin.
2. The method of claim 1 , wherein the cyclodextrin is SBE7-β-CD.
3. The method of claim 1 , wherein the cyclodextrin has a concentration (w/v) ranging from about 0.001% to about 50%.
4. The method of claim 1 , wherein the composition further comprises water.
5. The method of claim 1 , wherein the composition further comprises one or more of lactose, dextrose, mannitol, a pH buffering agent, an antioxidant agent, a preservative agent, a tonicity adjuster, or a combination thereof.
6. The method of claim 1 , wherein the composition comprises d-cis-3-(4-hydroxyphenyl)-4-(4-hydroxyphenyl)-8-methylchroman-7-ol in an amount of about 0.2-50 mg/mL.
7. The method of claim 1 , wherein the breast cancer is metastatic breast cancer.
8. The method of claim 1 , wherein the breast cancer is metastatic HER2-negative breast cancer.
9. The method of claim 1 , wherein the breast cancer has lost sensitivity to a chemotherapeutic agent, anti-cancer agent, or radiation therapy.