Methods of treating epithelioid cell tumors comprising administering a composition comprising nanoparticles comprising an mTOR inhibitor and an albumin

1. A method of treating a malignant perivascular epithelioid cell tumor (PEComa) in an individual, comprising intravenously administering to the individual an effective amount of a composition comprising nanoparticles comprising sirolimus and an albumin, wherein the effective amount of sirolimus in the nanoparticle composition is about 56 mg/m 2 to about 100 mg/m 2 , and wherein the nanoparticle composition is administered on days 1 and 8 of a 21-day cycle.

2. The method of claim 1 , wherein the PEComa is selected from the group consisting of a pulmonary clear cell ‘sugar’ tumor, and a PEComa not otherwise specified (PEComa-NOS).

3. The method of claim 1 , wherein the PEComa is locally advanced, metastatic, or recurrent.

4. The method of claim 1 , wherein the nanoparticles in the composition have an average diameter of no greater than about 150 nm.

5. The method of claim 1 , wherein sirolimus in the nanoparticles is coated with the albumin.

6. The method of claim 1 , wherein the weight ratio of albumin and sirolimus in the nanoparticle composition is about 1:1 to about 9:1.

7. The method of claim 1 , wherein the albumin is human albumin.

8. The method of claim 7 , wherein the albumin is human serum albumin.

9. The method of claim 1 , wherein the individual is human.

10. The method of claim 1 , wherein the effective amount of sirolimus in the nanoparticle composition is about 100 mg/m 2 .

11. The method of claim 1 , wherein the effective amount of sirolimus in the nanoparticle composition is about 75 mg/m 2 .

12. The method of claim 1 , wherein the effective amount of sirolimus in the nanoparticle composition is about 56 mg/m 2 .