Chemical sensor
View Patent ↗A transistor device ( 10 ) is disclosed comprising a source electrode ( 14 ) a drain electrode ( 12 ) and an enzyme ( 31 ) for facilitating generation of a charge carrier from an analyte. The transistor device also comprises a polymer layer ( 30 ) for retaining the enzyme ( 31 ), the polymer layer ( 30 ) being conductive to the charge carrier. The device also comprises an ohmic conductor ( 32 ) in contact with said polymer layer ( 30 ) for applying a gate voltage to said polymer layer ( 30 ). The device also comprises an organic semiconducting layer ( 18 ) connecting the source electrode ( 14 ) to the drain electrode ( 12 ). Also disclosed is a method of making and using the device ( 10 ).
1. A transistor device comprising:
a source electrode;
a drain electrode;
an enzyme for facilitating generation of a charge carrier from an analyte;
a polymer layer for retaining the enzyme, the polymer layer being conductive to the charge carrier;
an ohmic conductor in contact with said polymer layer for applying a gate voltage to said polymer layer; and
an organic semiconducting layer in contact with said polymer layer, the organic semiconducting layer connecting the source electrode to the drain electrode.
2. A transistor according to claim 1 , wherein a layer of the enzyme is formed on a surface of the polymer layer.
3. A transistor according to claim 1 , wherein neither said polymer layer nor said semiconducting layer include poly (4-vinylphenol) (PVP).
4. A device according to claim 1 , wherein organic semiconductor layer has a thickness of less than about 390 nm.
5. A device according to claim 1 , wherein the organic semiconductor layer has a thickness of between about 36 nm and about 9 nm.
6. A device according to claim 1 , wherein the organic semiconductor layer has a thickness between about 74 nm and about 108 nm.
7. A device according to claim 1 , wherein the carrier is a proton.
8. A device according to claim 1 , wherein said polymer layer forms a proton-conductive membrane.
9. A device according to claim 1 , wherein the polymer layer has a conductivity to protons that is greater than a conductivity to protons that is possessed by said organic semiconductor layer.
10. A device according to claim 1 , wherein at least part of the polymer layer is disposed above the semiconductor layer with respect to a substrate layer.
11. A device according to claim 1 , wherein at least part of the ohmic conductor is disposed beneath part of the polymer layer.
12. A device according to claim 1 , wherein the enzyme is glucose oxidase for detecting glucose in saliva.
13. A device according to claim 1 , wherein the organic semiconductor comprises, consists, or consists essentially of at least one organic compound that has semiconducting properties, the at least one organic compound being any one or more of: polyacetylenes, porphyrins, phthalocyanins, fullerenes, polyparaphenylenes, polyphenylenevinylenes, polyfluorenes, polythiophenes, polypyrroles, polypyridines, polycarbazoles, polypyridinevinylenes, polyarylvinylenes, poly (p-phenylmethylvinylenes), including derivatives and co-polymers thereof, and further including mixtures thereof.
14. A device according to any one of claim 13 , wherein the at least one organic compound is poly(3-hexyl-thiophene), ie P3HT.
15. A device according to claim 1 , wherein the polymer layer comprises, consists, or consists essentially of a sulfonated tetrafluoroethylene-based fluoropolymer-copolymer.
16. A device according to claim 15 , wherein the sulfonated tetrafluoroethylene-based fluoropolymer-copolymer is a tetrafluoroethylene-perfluoro-3,6-dioxa-4-methyl-7-octenesulfonic acid copolymer.
17. A method for preparing a transistor device as defined in claim 1 , the method comprising:
a) providing a substrate for depositing thereon components of the device;
b) depositing the source electrode and the drain electrode;
c) depositing the organic semiconductor;
d) depositing the polymer; and
e) depositing the enzyme on said polymer.
18. A method for preparing a transistor device according to claim 17 , wherein step b) precedes step c), step c) precedes step d), and step d) precedes step e).
19. A method for preparing a transistor device according to claim 17 , wherein the enzyme after step d).
20. A method for preparing a transistor device according to claim 17 , wherein the enzyme is introduced by ink-jet printing.
21. A method for preparing a transistor device according to claim 17 , wherein the semiconductor layer is deposited by spin coating.
22. A method for preparing a transistor device according to claim 17 , wherein the polymer layer is deposited by spin coating.
23. A method for detecting and/or determining a concentration or an amount of an analyte in a sample, the method comprising the following steps:
a) providing a device of claim 1 ;
b) contacting the sample with the device; and
c) detecting and/or determining the concentration or the amount of the analyte based on an electrical parameter of the device.
24. A transistor device comprising:
a source electrode;
a drain electrode;
an enzyme for facilitating generation of a charge carrier from an analyte;
a polymer layer for retaining the enzyme, the polymer layer being conductive to the charge carrier;
an ohmic conductor in contact with said polymer layer for applying a gate voltage to said polymer; and
an organic semiconductor layer connecting the source electrode to the drain electrode;
wherein a layer of the enzyme is formed on a surface of the polymer layer.