Pharmaceutical composition for treating and/or preventing cancer
The present application provides a pharmaceutical composition for treating and/or preventing a cancer comprising, as an active ingredient, a polynucleotide derived from miRNA associated with the cancer, a combination drug of the pharmaceutical composition and another antitumor agent, and a method for treating or preventing a cancer in a subject having the cancer using the pharmaceutical composition or the combination drug.
1. A method for treating a cancer in a subject in need thereof, comprising administering to the subject a pharmaceutical composition comprising, as an active ingredient, a polynucleotide 20-22 nucleotides in length and comprising a nucleotide sequence of any of SEQ ID NOs: 3 to 6 and 16 at the 3′ terminal side of the nucleotide sequence of SEQ ID NO:1 or 2;
and
wherein the cancer is selected from the group consisting of breast cancer, lung cancer, stomach cancer, liver cancer, colorectal cancer, pancreatic cancer, and leukemia.
2. The method according to claim 1 , wherein the polynucleotide comprises a nucleotide sequence of any of SEQ ID NOs:7 to 10, 12 and 13.
3. The method according to claim 1 , wherein the polynucleotide is single stranded or double stranded.
4. The method according to claim 1 , wherein the polynucleotide is RNA.
5. The method according to claim 1 , wherein the polynucleotide is inserted expressibly in a vector in the form of DNA.
6. The method according to claim 1 , wherein the polynucleotide is encapsulated in a carrier selected from the group consisting of non-cationic polymer carriers, liposome carriers, dendritic carriers, nano-material carriers, microparticle carriers, biostructural carriers, micelle carriers, polymer microparticles, and magnetic fine particles, or is bound thereto.
7. The method according to claim 1 , wherein the pharmaceutical composition is simultaneously or separately administered to a subject in combination with an antitumor agent.