Butyrate and beta-hydroxybutyrate compositions
View Patent ↗Compositions and methods for providing a person with an exogenous and therapeutically effective supply of ketones are disclosed. The compositions may consist essentially of (a) purified butyrate (or esters or propionate salts thereof) and (b) purified beta-hydroxybutyrate (or esters or propionate salts thereof). The compositions may further include other pharmacologically active agents, such as acetyl-L carnitine, R-alpha lipoic acid, green tea extract, vitamins, and various combinations of such agents. The methods include providing a person with an exogenous supply of ketones, by orally administering a pharmacologic composition, which is effective to deliver 2000-5000 mg of a short chain fatty acid (e.g., butyrate) and 5000-10,000 mg of ketone (e.g., beta-hydroxybutyrate) on a daily basis.
1. A composition comprising:
(a) purified butyrate or esters or propionate salts thereof, wherein the purified butyrate includes a butyrate sodium salt, a butyrate calcium salt, or a butyrate magnesium salt; and
(b) purified beta-hydroxybutyrate or esters or propionate salts thereof, wherein the purified beta-hydroxybutyrate includes a beta-hydroxybutyrate sodium salt, a beta-hydroxybutyrate calcium salt, or a beta-hydroxybutyrate magnesium salt, wherein the composition is packaged in a form selected from the group consisting of (i) an oral capsule, (ii) in powdered form, (iii) in an aqueous or non-aqueous liquid, (iv) in an oil-in-water or water-in-oil emulsion, (v) in an elixir or syrup, or (vi) in a paste, wherein the composition is effective to deliver 1000- 5000 mg of a short chain fatty acid and 1000-10,000 mg of ketone to a person on a daily basis.
2. The composition of claim 1 , which further comprises an agent selected from the group consisting of acetyl-L carnitine, R-alpha lipoic acid, and green tea extract.
3. The composition of claim 1 , which further comprises one or more vitamins.
4. The composition of claim 1 , which further comprises one or more preservatives.
5. The composition of claim 1 , wherein the total purified butyrate to total purified beta-hydroxybutyrate ratio is about 1:1.
6. A method for providing a person with an exogenous supply of ketones, by orally administering a composition of claim 1 to the person, which is effective to deliver 1000-5000 mg of a short chain fatty acid and 1000-10,000 mg of ketone on a daily basis.
7. The method of claim 6 , wherein the composition further comprises an agent selected from the group consisting of acetyl-L carnitine, R-alpha lipoic acid, and green tea extract.
8. The method of claim 6 , wherein the composition further comprises one or more vitamins.
9. The method of claim 6 , wherein the composition further comprises one or more preservatives.
10. The method of claim 6 , wherein the total purified butyrate to total purified beta-hydroxybutyrate ratio is about 1:1.
11. The method of claim 6 , wherein the total purified butyrate to total purified beta-hydroxybutyrate ratio is about 2:1.