IP Library › Granted Patent US 10,987,651
Granted Patent B2
US 10,987,651 · App. 15/748,542 · Granted Apr 27, 2021

Endotoxin adsorbent

Inventors: Masayo Sakata (Kumamoto, JP); Towako Sakamoto (Kumamoto, JP); Daisuke Nakamura (Hyogo, JP); Yuki Maeda (Hyogo, JP)
Assignees: National University Corporation Kumamoto University; Nagase ChemteX Corporation
B01J20/24A61K9/70A61K47/38B01D15/00B01D15/36B01D15/363B01J20/22B01J20/262B01J20/265B01J20/28004B01J20/28007B01J20/28023B01J20/30B01J20/3085B01J20/3212B01J20/3248C02F1/28C02F1/42C02F2001/422C02F2101/34
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Quick Facts
Patent No.
US 10,987,651
App. No.
15/748,542
Granted
Apr 27, 2021
Kind
B2
Abstract

Means for removing endotoxin is provided. Endotoxin is removed by contacting an endotoxin adsorbent including a cellulose nanofiber having an amino group with a liquid containing endotoxin.

Claims (19)

1. An endotoxin adsorbent, comprising:

a cellulose nanofiber having an amino group.

2. The endotoxin adsorbent according to claim 1 , wherein the amount of the amino group in the cellulose nanofiber is from 0.05 to 3.0 meq/dry-g.

3. The endotoxin adsorbent according to claim 1 , wherein the cellulose nanofiber has an average fiber diameter of from 1 to 1000 nm.

4. A method for producing the endotoxin adsorbent according to claim 1 , the method comprising:

a step of introducing an amino group into a cellulose nanofiber.

5. A method for removing endotoxin, the method comprising:

contacting the endotoxin adsorbent according to claim 1 with a liquid containing endotoxin.

6. A method for producing a liquid from which endotoxin has been removed, the method comprising:

contacting the endotoxin adsorbent according to claim 1 with a liquid containing endotoxin.

7. A method for removing endotoxin, the method comprising:

contacting the endotoxin adsorbent according to claim 1 with a liquid containing a target substance and endotoxin.

8. A method for producing a liquid that contains a target substance and from which endotoxin has been removed, the method comprising:

contacting the endotoxin adsorbent according to claim 1 with a liquid containing the target substance and endotoxin.

9. The method according to claim 7 , wherein the target substance is a substance exhibiting a negative charge.

10. The method according to claim 7 , wherein the target substance is a protein having an isoelectric point of from 4.0 to 10.5.

11. The method according to claim 8 , wherein the target substance is a substance exhibiting a negative charge.

12. The method according to claim 8 , wherein the target substance is a protein having an isoelectric point of from 4.0 to 10.5.

13. The endotoxin adsorbent according to claim 1 , wherein the amount of the amino group in the cellulose nanofiber is from 0.1 to 2.0 meq/dry-g.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 19, 2021
From: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY
To: NAGASE CHEMTEX CORPORATION
Reel/Frame 056286/0081 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 30, 2018
From: SAKATA, MASAYO; SAKAMOTO, TOWAKO; NAKAMURA, DAISUKE; MAEDA, YUKI
To: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY; NAGASE CHEMTEX CORPORATION
Reel/Frame 044762/0662 →
Priority Claims (1)
JP JP2015-151271 · Jul 30, 2015 · national
Continuity (1)
Related Publication 20180178192A1 · Jun 28, 2018
Cited By (1)
US 12,397,283