Methods of treating acute myeloid leukemia
View Patent ↗A method of treating acute myeloid leukemia (AML), including the steps of (i) measuring a density of blast cells in the peripheral blood and the bone marrow of a subject with AML; (ii) administering to the subject a CXCR4 antagonist; and (iii) administering to the subject a therapeutically effective amount of the CXCR4 antagonist and a therapeutically effective amount of a chemotherapeutic agent, if the blast cell density in the peripheral blood is less than 10% of the total peripheral white blood cells, or at least five-fold lower than the blast cell density in the bone marrow, or at least two-fold higher one day or more following step (ii).
1. A method of treating Acute Myeloid Leukemia (AML) in a human subject, the method comprising:
a) administering a CXCR4 antagonist without a chemotherapeutic agent in said human subject,
b) analyzing blast cells in the peripheral blood of said human subject at least one day following method step a), and
c) co-administering a CXCR4 antagonist with a chemotherapeutic agent in said human subject if there is at least a two-fold increase in blast cells in the peripheral blood of said subject thereby treating AML in said subject.
2. The method of claim 1 , wherein said CXCR4-antagonist is as set forth in SEQ ID NO: 1.
3. The method of claim 2 , wherein said chemotherapeutic agent comprises cytarabine (ARA-C).
4. The method of claim 1 , wherein said subject exhibits at least a two-fold increase in blast cells in the peripheral blood 2 to 4 days following administration of said CXCR4 antagonist without said chemotherapeutic agent.