Immunomodulatory antibodies
The invention relates to antibodies specific for 4-1BB and OX40, as well as to methods for using such antibodies and therapeutic uses thereof.
1. An isolated monoclonal antibody which specifically binds to the cysteine rich repeat sequences in one or more of the extracellular domains 3 or 4 of OX40 comprising a:
(a) heavy chain CDRs comprising SEQ ID NO: 37-39 and light chain CDRs comprising SEQ ID NO: 40-42;
(b) heavy chain CDRs comprising SEQ ID NO: 43-45 and light chain CDRs comprising SEQ ID NO: 46-48;
(c) heavy chain CDRs comprising SEQ ID NO: 49-51 and light chain CDRs comprising SEQ ID NO: 52-54; or
(d) heavy chain CDRs comprising SEQ ID NO: 55-56 and light chain CDRs comprising SEQ ID NO: 58-60.
2. The isolated monoclonal antibody according to claim 1 wherein the Fc region of the antibody is derived from either the mouse IgG1 or human IgG2 isotype.
3. The isolated monoclonal antibody according to claim 2 , wherein the antibody is of hIgG2 isotype.
4. The isolated monoclonal antibody according to claim 1 comprising heavy chain CDRs having SEQ ID NO: 37-39 and light chain CDRs having SEQ ID NO: 40-42.