Granted Patent
B2
US 11,008,316 · App. 15/490,385 · Granted May 18, 2021
Glucosylceramide synthase inhibitors
Inventors:
Elyse Bourque (Blaine, WA); Mario A. Cabrera-Salazar (Brighton, MA); Cassandra Celatka (Hull, MA); Seng H. Cheng (Natick, MA); Bradford Hirth (Littleton, MA); Andrew Good (Wallingford, CT); Katherine Jancsics (Wilmington, MA); John Marshall (Charlestown, MA); Markus Metz (Encinitas, CA); Ronald K. Scheule (Hopkinton, MA); Renato Skerlj (W. Newton, MA); Yibin Xiang (Dracut, MA); Zhong Zhao (Wayland, MA); John Leonard (Manchester, NH); Thomas Natoli (Revere, MA); Elina Makino (Winchester, MA); Herve Husson (Boston, MA); Oxana Beskrovnaya (Southborough, MA)
Assignee:
GENZYME CORPORATION
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Abstract
The invention relates to inhibitors of glucosylceramide synthase (GCS), such as Compound of Formula I, shown below, as defined herein, useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.
Claims (3)
1. A compound of the formula
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition comprising an effective amount of a compound according to claim 1 and at least one pharmaceutically acceptable carrier.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 17, 2017
From: BOURQUE, ELYSE; CABRERA-SALAZAR, MARIO; CELATKA, CASSANDRA
To: GENZYME CORPORATION
Reel/Frame 043315/0273 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 17, 2017
From: BOURQUE, ELYSE; CABRERA-SALAZAR, MARIO; CELATKA, CASSANDRA; CHENG, SENG; HIRTH, BRADFORD; GOOD, ANDREW; JANCSICS, KATHERINE; MARSHALL, JOHN; METZ, MARKUS; SCHEULE, RONALD; SKERLJ, RENATO; XIANG, YIBIN; ZHAO, ZHONG; LEONARD, JOHN; NATOLI, THOMAS; MAKINO, ELINA; HUSSON, HERVE; BESKROVNAYA, OXANA
To: GENZYME CORPORATION
Reel/Frame 043322/0180 →
Continuity (3)
Continuation
14427275
Provisional Application
61699714
· Sep 11, 2012
Cited By (5)