Topical composition and delivery system and its use
The described invention provides a topical delivery system comprising a pharmaceutical composition for application directly to a skin of a subject in need thereof comprising (a) an effective therapeutic amount of an active therapeutic agent; (b) chemical drivers comprising an amino benzoate local anesthetic, ethoxydiglycol and methylsulfonylmethane (MSM) that in combination are effective to synergistically deliver the therapeutic agent; and (c) a depot component for keeping the pharmaceutical composition in the skin. Methods for delivering an active therapeutic agent into skin, for keeping it in the skin, for reducing systemic side effects attributable to entry of the active agent into the blood stream, and a method for treating a condition, disease or disorder of skin topically also are described in accordance with the embodiments of the described invention.
1. A topical delivery system comprising a pharmaceutical composition formulated for application directly to a skin of a subject in need thereof, comprising:
(a) a therapeutic amount of an amino benzoate local anesthetic agent;
(b) chemical drivers comprising ethoxydiglycol, propylene glycol, and methylsulfonylmethane (MSM), wherein the chemical drivers are cooperatively effective to deliver the amino benzoate local anesthetic agent into skin; and
(c) a depot component that is effective to keep the aminobenzoate local anesthetic agent locally in the skin and to reduce distribution of the aminobenzoate local anesthetic agent to the blood stream, wherein the depot component is selected from the group consisting of a liposome, a polymer, a polymersome, and a combination thereof.
2. The topical delivery system according to claim 1 , wherein the amino benzoate local anesthetic agent is selected from the group consisting of benzocaine, lidocaine, tetracaine or a combination thereof.
3. The topical delivery system according to claim 1 , wherein the pharmaceutical composition is in an administration form selected from the group consisting of a cream, a gel, or a spray.
4. The topical delivery system according to claim 1 , further comprising a vasoconstrictor.
5. The topical delivery system according to claim 4 , wherein the vasoconstrictor is nonirritating when applied to skin.
6. The topical delivery system according to claim 4 , wherein the vasoconstrictor is phenylephrine.
7. The topical delivery system according to claim 1 , wherein the liposome comprises a phosphatidyl choline, cholesterol, and at least one anionic or cationic phospholipid.
8. The topical delivery system according to claim 1 , wherein the liposome comprises a pharmaceutically acceptable salt of an active therapeutic agent.
9. The topical delivery system according to claim 8 , wherein the active therapeutic agent is selected from the group consisting of a steroidal analgesic agent, a non-steroidal analgesic agent, a wound healing agent, an anti-inflammatory agent, an antihistamine agent, an anti-neoplastic agent, or a combination thereof.