Stacked layer-type member with integrated functional component
A fluidic valve for a sample separation apparatus for separating a fluid, wherein the fluidic valve comprises a stack of connected layer structures, a first conduit within the stack, a second conduit within the stack, a movable body within the stack, and an actuator configured for actuating the movable body to selectively bring the movable body into a flow enabling configuration in which flow of fluid between the first conduit and the second conduit is enabled, or into a flow disabling configuration in which flow of fluid between the first conduit and the second conduit is disabled.
1. A fluidic valve for a sample separation apparatus for separating a fluid, the fluidic valve comprising:
a planar member comprising a stack of layer structures and a non-metallic movable body movable within the stack, wherein the stack comprises a stack of metallic layer structures connected to one another by diffusion bonding;
a first conduit within the stack;
a second conduit within the stack;
an actuator configured for actuating the movable body to selectively bring the movable body into a flow enabling configuration in which flow of fluid between the first conduit and the second conduit is enabled, or into a flow disabling configuration in which flow of fluid between the first conduit and the second conduit is disabled; and
a force transmission structure configured for transmitting an actuation force from the actuator to the movable body, the force transmission structure comprising:
an elastic membrane as at least one of the layer structures, the elastic membrane arranged between the actuator and the movable body; and
an elastic pad arranged between the actuator and the elastic membrane.
2. The fluidic valve according to claim 1 , wherein at least one of the layer structures is configured as a sheet.
3. The fluidic valve according to claim 1 , wherein at least one of the layer structures is configured as a patterned layer comprising one or more recesses constituting at least part of at least one of the first conduit and the second conduit.
4. The fluidic valve according to claim 1 , wherein the movable body is configured as a ball.
5. The fluidic valve according to claim 1 , wherein the movable body comprises at least one material selected from the group consisting of an inorganic material, a ceramic, a metal oxide, sapphire, ruby, and a hard plastic material.
6. The fluidic valve according to claim 1 , wherein the movable body is configured for being forced to sealingly rest on a seat, formed by at least a part of the layer structures, by the actuator in the fluid disabling configuration, and is configured for being released from the seat when brought in the fluid enabling configuration by the actuator.
7. The fluidic valve according to claim 1 wherein the elastic pad has a larger lateral extension than at least one of the actuator and the movable body.
8. The fluidic valve according to claim 1 , comprising at least one of the following features:
the actuator comprises a piston configured for axially moving so as to selectively actuate the movable body to be brought into the fluid enabling configuration or into the fluid disabling configuration depending on an axial position of the piston;
wherein at least one of the layer structures is configured as a spring-type layer;
configured as a non-return valve.
9. A sample separation apparatus for separating a fluidic sample, comprising:
a fluid drive unit configured for driving at least a part of a fluid comprising a mobile phase and the fluidic sample in the mobile phase along a separation path;
a separation unit arranged within the separation path and configured for separating the fluidic sample into a plurality of fractions; and
the fluidic valve according to claim 1 configured for selectively enabling or disabling flow of at least a part of the fluid within or into the separation path.
10. The sample separation apparatus according to claim 9 , comprising at least one of the following features:
the sample separation apparatus is configured as one of: a chromatography sample separation apparatus; a liquid chromatography sample separation apparatus; a gas chromatography sample separation apparatus; a supercritical fluid chromatography sample separation apparatus; an electrophoresis sample separation apparatus; and, in particular a capillary electrophoresis sample separation apparatus;
the sample separation apparatus comprises an injector for introducing the fluidic sample into the mobile phase between the fluid drive unit and the separation unit;
the sample separation apparatus comprises a detector configured to detect separated fractions of at least a portion of the fluidic sample;
the sample separation apparatus comprises a fractionating unit configured to collect separated fractions of the fluidic sample;
the sample separation apparatus comprises a degassing apparatus for degassing mobile phase;
the fluid drive unit is configured for driving the fluid along the separation path with a pressure of at least 200 bar.
11. A method of manufacturing a fluidic valve, the method comprising:
forming the planar member of claim 1 by:
forming a first conduit within the stack;
forming a second conduit within the stack;
arranging the movable body to be movable within the stack;
arranging the force transmission structure to be between the actuator and the movable body; and
interconnecting at least a part of the stack by diffusion bonding; and
configuring the actuator for actuating the movable body to selectively bring the movable body into the flow enabling configuration or into the flow disabling configuration.
12. The fluidic valve according to claim 1 , wherein the metallic layer structures have a composition and thickness effective to withstand an applied pressure of at least up to 1000 bar.