IP Library Granted Patent US 11,045,491
Granted Patent B2
US 11,045,491 · App. 15/771,858 · Granted Jun 29, 2021

Anti-virus agent and method for treatment of viral infection

Inventors: Graham John Hamilton Melrose (Mount Claremont, AU); Michele Keryn Dilizia (Hillarys, AU)
Assignee: RECCE PHARMACEUTICALS LTD
A61K31/78A61K9/0019A61K9/0053A61K9/0073A61K9/20A61K9/48A61K47/10A61P31/16A61P31/18A61P31/22
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Quick Facts
Patent No.
US 11,045,491
App. No.
15/771,858
Granted
Jun 29, 2021
Kind
B2
Abstract

A method of treatment of viral infection in a subject comprising administering to the subject a copolymer comprising an acrolein derived segment or a polyacrolein oligomer segment and a polyalkylene glycol oligomer segment, the copolymer having a molecular weight of no more than 1500 Daltons.

Claims (13)

1. A method of treatment of a parenteral viral infection in a subject comprising systemically administering to the subject a copolymer comprising an acrolein-derived segment and a polyalkylene glycol oligomer segment, the copolymer having a molecular weight of no more than 1000 Daltons, wherein the copolymer is administered by a route selected from the group consisting of: oral administration, inhalation, transdermal delivery, injection and infusion.

2. The method according to claim 1 , wherein the acrolein-derived segment is a polyacrolein oligomer comprising two or more acrolein residues.

3. The method according to claim 1 , wherein the copolymer has a molecular weight of from 300 to 1000 Daltons.

4. The method according to claim 1 , wherein the polyalkylene glycol oligomer segment has a molecular weight in the range of from 200 to 600 Daltons.

5. The method according to claim 1 , wherein the polyalkylene glycol oligomer segment has a molecular weight in the range of from 200 to 400 Daltons.

6. The method according to claim 1 , wherein a polyalkylene glycol of the polyalkylene glycol oligomer segment is polyethylene glycol.

7. The method according to claim 1 , wherein the copolymer is administered by oral administration.

8. The method according to claim 1 , wherein the copolymer is administered by intravenous injection or infusion.

9. The method according to claim 1 , wherein the copolymer is administered as an aqueous solution comprising a copolymer concentration in the range of from 0.01% by weight to 20% by weight of the aqueous solution.

10. The method according to claim 1 , wherein the copolymer is administered orally in the form of a tablet, caplet, syrup or liquid.

11. The method according to claim 1 , wherein the copolymer is administered systemically at a dose in the range of from 1 mg to 1000 mg per kilogram of bodyweight per day.

12. The method according to claim 1 , wherein the parenteral viral infection is selected from the group consisting of a influenza viral infection, an HIV infection, a hepatitis viral infection, a Ross River viral infection, and a herpes viral infection.

13. The method according to claim 1 , wherein the parenteral viral infection is an influenza viral infection.

Assignments (2)
SECURITY INTEREST Recorded Jun 16, 2025
From: RECCE PHARMACEUTICALS LIMITED; GRAMELE INDUSTRIAL HOLDINGS PTY LIMITED
To: AVENUE VENTURE OPPORTUNITIES FUND II, L.P., AS AGENT
Reel/Frame 071420/0403 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 3, 2018
From: MELROSE, GRAHAM JOHN HAMILTON; DILIZIA, MICHELE KERYN
To: RECCE LIMITED
Reel/Frame 046257/0946 →
Priority Claims (2)
AU 2016900595 · Feb 19, 2016 · national
AU 2016902715 · Jul 11, 2016 · national
Continuity (1)
Related Publication 20180338994A1 · Nov 29, 2018