Methods and compositions for inducing an immune response
The present invention provides a composition comprising a) a polyacetal polymer, a polyester polymer and/or a biodegradable polymer; b) a cyclic dinucleotide; and c) an antigen and/or an antibody, as well as methods of using same.
1. A method of ameliorating, alleviating, decreasing symptom(s), or delaying progression of an infectious disease, cancer, or an autoimmune disorder that requires activation of the stimulator of interferon genes (STING) pathway, comprising administering to a subject in need thereof an effective amount of a composition comprising:
a) acetalated dextran;
b) an agonist of the stimulator of interferon genes (STING) receptor and/or a different immunostimulatory agent; and
c) optionally, an antigen,
wherein the composition is formulated in electrosprayed microparticles.
2. The method according to claim 1 , further comprising administering an antibody to the subject.