IP Library Granted Patent US 11,071,499
Granted Patent B2
US 11,071,499 · App. 15/185,183 · Granted Jul 27, 2021

Multichannel ultra-low noise amplifier

Inventors: Dominique M. Durand (Solon, OH); Yazan M. Dweiri (Cleveland, OH)
Assignee: CASE WESTERN RESERVE UNIVERSITY
A61B5/7203A61B5/24A61B5/7225H03F3/45183A61B2503/40H03F2200/261H03F2200/294H03F2203/45288H03F2203/45322H03F2203/45371
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Quick Facts
Patent No.
US 11,071,499
App. No.
15/185,183
Granted
Jul 27, 2021
Kind
B2
Abstract

The present disclose generally relates to a multichannel low-noise amplifier. At each input to the multichannel low-noise amplifiers, a plurality of transistors can be connected in parallel. This parallel connection decreases the voltage noise beyond what is possible using a single input transistor at each input. As an additional benefit, the initial operating region of the input transistors is not changed. The multichannel low-noise amplifier can be incorporated on a single integrated circuit chip to amplify biological signals to facilitate selective recording of a property (e.g., amplifying neural signals to facilitate selective recording of neural activity).

Claims (21)

1. An apparatus comprising:

a plurality of channels each configured to receive a unique weak electrical signal from signal recording devices, wherein each of the unique weak electrical signals is a neural signal; and

an amplifier circuit comprising:

a differential input circuit configured to input the unique weak electrical signals comprising:

a number of inverting input parallel transistors to receive an inverting input voltage paired to

an equal number of non-inverting input parallel transistors to receive a non-inverting input voltage,

wherein the number and the equal number are at least four, and at least equal to another number of the plurality of channels, a current mirror circuit; and

an output configured to provide amplified weak electrical signals, wherein the amplified weak electrical signals comprise noise reduced at least by the square root of the other number of the plurality of channels.

2. The apparatus of claim 1 , wherein the transistors each comprise a complimentary metal-oxide semiconductor (CMOS) transistor.

3. The apparatus of claim 1 , wherein the current mirror circuit is coupled to a plurality of parallel transistor pairs and the output, and is biased based on a biasing current voltage.

4. A system comprising:

a plurality of signal recording devices, each configured to record an unique weak electrical signal, wherein each of the unique weak electrical signals is a neural signal;

an apparatus comprising:

a plurality of channels each configured to receive the unique weak electrical signal from the plurality of signal recording devices; and

an amplifier circuit comprising:

a differential input circuit configured to input the unique weak electrical signals comprising:

a number of inverting input parallel transistors to receive an inverting input voltage paired to

an equal number of non-inverting input parallel transistors to receive a non-inverting input voltage,

wherein the number and the equal number are at least four, and at least equal to another number of the plurality of channels a current mirror circuit; and

an output configured to provide amplified weak electrical signals, wherein the amplified weak electrical signals comprise noise reduced by at least the square root of the other number of the plurality of channels.

5. The system of claim 4 , wherein the number of inverting input parallel transistors and the equal number of non-inverting input parallel transistors each comprise a complimentary metal-oxide semiconductor (CMOS) transistor.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 5, 2018
From: DURAND, DOMINIQUE M.; DWEIRI, YAZAN M.
To: CASE WESTERN RESERVE UNIVERSITY
Reel/Frame 045985/0106 →
CONFIRMATORY LICENSE Recorded Jul 13, 2016
From: CASE WESTERN RESERVE UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 039323/0256 →
Continuity (2)
Provisional Application 62337445 · May 17, 2016
Related Publication 20170332973A1 · Nov 23, 2017