Identification of false asystole detection

1. A medical system comprising:

a plurality of electrodes configured to sense a cardiac electrogram of a patient; and

processing circuitry configured to:

determine that an asystole detection criterion is satisfied based on not identifying a cardiac depolarization in the cardiac electrogram during a time interval;

based on the determination that the asystole detection is satisfied, determine whether a plurality of false asystole detection criteria are satisfied based on the cardiac electrogram signal; and

withhold an indication of an asystole episode for the patient based on a determination that at least one of the plurality of false asystole detection criteria is satisfied,

wherein the plurality of false asystole detection criteria comprises:

a first false asystole detection criterion including a reduced amplitude threshold for detecting cardiac depolarizations in the cardiac electrogram; and

a second false asystole detection criterion for detecting decaying noise in the cardiac electrogram, and

wherein, to determine that the first false asystole detection criterion is satisfied, the processing circuitry is configured to:

identify a plurality of cardiac depolarizations occurring in the cardiac electrogram preceding the time interval;

determine an amplitude for each cardiac depolarization of the plurality of identified cardiac depolarizations;

determine the reduced amplitude threshold based on the determined amplitudes of the plurality of identified cardiac depolarizations.

2. The medical system of claim 1 , wherein, to determine that the first false asystole detection criterion is satisfied, the processing circuitry is configured to:

compare the reduced amplitude threshold to the cardiac electrogram during the time interval; and

determine that a threshold number of cardiac depolarizations is identified in the cardiac electrogram during the time interval based on the comparison.

3. The medical system of claim 1 , wherein the processing circuitry is configured to:

determine a representative amplitude based on the amplitudes of each the plurality of identified cardiac depolarizations; and

determine the reduced amplitude threshold as a predetermined portion of the representative amplitude.

4. The medical system of claim 1 , wherein, to determine that the second false asystole detection criterion is satisfied, the processing circuitry is configured to:

calculate an area-under-the-curve value for the cardiac electrogram during at least a portion of the time interval; and

determine that the area-under-the-curve value satisfies an area-under-the-curve threshold.

5. The medical system of claim 1 , wherein, to determine that the second false asystole detection criterion is satisfied, the processing circuitry is configured to:

determine a differential signal of the cardiac electrogram during at least a portion of the time interval;

for each of a plurality of samples of the differential signal, determine whether a sign of the sample is positive or negative; and

determine that an amount of samples having one of the signs satisfies a common sign threshold.

6. The medical system of claim 1 , wherein the plurality of false asystole detection criteria further comprises a third false asystole detection criterion, wherein, to determine that the third false asystole detection criterion is satisfied, the processing circuitry is configured to:

identify a plurality of cardiac depolarizations occurring in the cardiac electrogram preceding the time interval;

determine an amplitude for each of the plurality of identified cardiac depolarizations;

determine a variability of the amplitudes; and

determine that the variability satisfies a variability threshold.

7. The medical system of claim 6 , wherein, to determine the variability of the amplitudes, the processing circuitry is configured to:

determine a maximum amplitude of the plurality of amplitudes;

determine a representative amplitude of the plurality of amplitudes; and

determine a metric of comparison of the maximum amplitude to the representative amplitude.

8. The medical system of claim 1 , wherein the plurality of false asystole detection criteria further comprises a third false asystole detection criterion, wherein, to determine that the third false asystole detection criterion is satisfied, the processing circuitry is configured to:

identify a plurality of cardiac depolarizations occurring in the cardiac electrogram preceding the time interval;

determine one or more intervals between adjacent ones of the plurality of cardiac depolarizations;

based on the determined intervals, identify one or more expected cardiac depolarization windows and one or more expected inter-depolarization windows within the time interval;

determine a first energy of the one or more cardiac depolarization windows and a second energy of the one or more inter-depolarization windows;

determine a metric of comparison of the first energy to the second energy; and

determine that the metric of comparison satisfies a threshold.

9. The medical system of claim 1 , wherein the processing circuitry is configured to:

determine a count of instances of satisfaction of the asystole detection criterion within a time period; and

determine whether the count satisfies at least one asystole count criterion,

wherein the processing circuitry is configured to determine whether the plurality of false asystole detection criteria are satisfied based on determining that the count satisfies at least one asystole count criterion.

10. The medical system of claim 1 , wherein the plurality of electrodes are configured for subcutaneous implantation, and the cardiac electrogram comprises a subcutaneous cardiac electrogram.

11. The medical system of claim 1 , wherein the plurality of electrodes are configured for extravascular implantation, and the cardiac electrogram comprises an extravascular cardiac electrogram.

12. A method comprising:

sensing a cardiac electrogram of a patient via a plurality of electrodes of a medical system;

determining, by processing circuitry of the medical system, that an asystole detection criterion is satisfied based on not identifying a cardiac depolarization in the cardiac electrogram during a time interval;

based on the determination that the asystole detection is satisfied, determining, by the processing circuitry, that at least one of a plurality of false asystole detection criteria are satisfied based on the cardiac electrogram signal; and

withholding, by the processing circuitry, an indication of an asystole episode for the patient based on a determination that at least one of the plurality of false asystole detection criteria is satisfied,

wherein the plurality of false asystole detection criteria comprises:

a first false asystole detection criterion including a reduced amplitude threshold for detecting cardiac depolarizations in the cardiac electrogram;

a second false asystole detection criterion for detecting decaying noise in the cardiac electrogram, and

wherein determining that the first false asystole detection criterion is satisfied comprises:

identifying, by the processing circuitry, one or more cardiac depolarizations occurring in the cardiac electrogram preceding the time interval;

determining, by the processing circuitry, an amplitude for each of the one or more identified cardiac depolarizations; and

determining by the processing circuitry, the reduced amplitude threshold based on the determined amplitudes of the one or more identified cardiac depolarizations.

13. The method of claim 12 , wherein determining that the first false asystole detection criterion is satisfied comprises:

comparing the reduced amplitude threshold to the cardiac electrogram during the time interval; and

determining that a threshold number of cardiac depolarizations is identified in the cardiac electrogram during the time interval based on the comparison.

14. The method of claim 12 , wherein determining the reduced amplitude threshold comprises:

determining a representative amplitude based on the amplitudes of each the plurality of identified cardiac depolarizations; and

determining the reduced amplitude threshold as a predetermined portion of the representative amplitude.

15. The method of claim 12 , wherein determining that the second false asystole detection criterion is satisfied comprises:

calculating an area-under-the-curve value for the cardiac electrogram during at least a portion of the time interval; and

determining that the area-under-the-curve value satisfies an area-under-the-curve threshold.

16. The method of claim 12 , wherein determining that the second false asystole detection criterion is satisfied comprises:

determining a differential signal of the cardiac electrogram during at least a portion of the time interval;

for each of a plurality of samples of the differential signal, determining whether a sign of the sample is positive or negative; and

determining that an amount of samples having one of the signs satisfies a common sign threshold.

17. The method of claim 12 , wherein the plurality of false asystole detection criteria further comprises a third false asystole detection criterion, wherein determining that the third false asystole detection criterion is satisfied comprises:

identifying a plurality of cardiac depolarizations occurring in the cardiac electrogram preceding the time interval;

determining an amplitude for each of the plurality of identified cardiac depolarizations;

determining a variability of the amplitudes; and

determining that the variability satisfies a variability threshold.

18. The method of claim 17 , wherein determining the variability of the amplitudes comprises:

determining a maximum amplitude of the plurality of amplitudes;

determining a representative amplitude of the plurality of amplitudes; and

determining a metric of comparison of the maximum amplitude to the representative amplitude.

19. The method of claim 12 , wherein the plurality of false asystole detection criteria further comprises a third false asystole detection criterion, and determining that the third false asystole detection criterion is satisfied comprises:

identifying a plurality of cardiac depolarizations occurring in the cardiac electrogram preceding the time interval;

determining one or more intervals between adjacent ones of the plurality of cardiac depolarizations;

based on the determined intervals, identifying one or more expected cardiac depolarization windows and one or more expected inter-depolarization windows within the time interval;

determining a first energy of the one or more cardiac depolarization windows and a second energy of the one or more inter-depolarization windows;

determining a metric of comparison of the first energy to the second energy; and

determining that the metric of comparison satisfies a threshold.

20. The method of claim 12 , further comprising, by the processing circuitry:

determining a count of instances of satisfaction of the asystole detection criterion within a time period; and

determining whether the count satisfies at least one asystole count criterion,

wherein determining whether the plurality of false asystole detection criteria are satisfied comprises determining whether the plurality of false asystole detection criteria are satisfied based on determining that the count satisfies the at least one asystole count criterion.

21. The method of claim 12 , wherein the plurality of electrodes are subcutaneously-implanted, and sensing the cardiac electrogram comprises sensing the cardiac electrogram via the plurality of subcutaneously-implanted electrodes.

22. The method of claim 12 , wherein the plurality of electrodes are extravascularly implanted, and sensing the cardiac electrogram comprises sensing the cardiac electrogram via the plurality of extravascularly-implanted electrodes.

23. A non-transitory computer-readable storage medium comprising program instructions that, when executed by processing circuitry of a medical system, cause the processing circuitry to:

determine that an asystole detection criterion is satisfied based on not identifying a cardiac depolarization in a cardiac electrogram during a time interval sensed via a plurality of electrodes of the medical system;

based on the determination that the asystole detection is satisfied, determine whether a plurality of false asystole detection criteria are satisfied based on the cardiac electrogram signal; and

withhold an indication of an asystole episode for the patient based on a determination that at least one of the plurality of false asystole detection criteria is satisfied,

wherein the plurality of false asystole detection criteria comprises:

a first false asystole detection criterion including a reduced amplitude threshold for detecting cardiac depolarizations in the cardiac electrogram; and

a second false asystole detection criterion for detecting decaying noise in the cardiac electrogram, and

wherein, to determine that the first false asystole detection criterion is satisfied, the processing circuitry is caused to:

identify a plurality of cardiac depolarizations occurring in the cardiac electrogram preceding the time interval;

determine an amplitude for each cardiac depolarization of the plurality of identified cardiac depolarizations; and

determine the reduced amplitude threshold based on the determined amplitudes of the plurality of identified cardiac depolarizations.