IP Library › Granted Patent US 11,071,728
Granted Patent B2
US 11,071,728 · App. 15/375,727 · Granted Jul 27, 2021

Treatment of schizophrenia

Inventor: Mihael H. Polymeropoulos (Potomac, MD)
Assignee: Vanda Pharmaceuticals Inc.
A61K31/454A61K9/0024
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Quick Facts
Patent No.
US 11,071,728
App. No.
15/375,727
Granted
Jul 27, 2021
Kind
B2
Abstract

Aspects of the invention relate generally to the treatment of schizophrenia and to monitoring for specific adverse reactions.

Claims (5)

1. A method of treating a patient with iloperidone who has previously exhibited one or more hypersensitivity reaction when treated with a first dose of iloperidone that is between 12 mg/day and 24 mg/day, the method comprising:

administering to the patient a second dose of iloperidone that is between 8 mg/day and 16 mg/day and less than the first dose of iloperidone,

wherein the hypersensitivity reaction includes one or more of anaphylaxis; angioedema; throat tightness; oropharyngeal swelling; or swelling of the face, lip, mouth, or tongue.

2. The method of claim 1 , wherein administering includes orally administering the second dose of iloperidone.

3. The method of claim 1 , wherein administering to the patient the second dose of iloperidone occurs following a discontinuation period.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 13, 2017
From: POLYMEROPOULOS, MIHAEL H.
To: VANDA PHARMACEUTICALS, INC.
Reel/Frame 043860/0280 →
Continuity (2)
Provisional Application 62266541 · Dec 11, 2015
Related Publication 20170165250A1 · Jun 15, 2017
Cited By (1)
US 12,606,869