IP Library Granted Patent US 11,071,764
Granted Patent B2
US 11,071,764 · App. 16/462,415 · Granted Jul 27, 2021

Synergistic dietary supplement compositions of

Inventors: Ganga Raju Gokaraju (Vijaywada, IN); Rama Raju Gokaraju (Vijayawada, IN); Venkata Kanaka Ranga Raju Gokaraju (Vijayawada, IN); Trimurtulu Golakoti (Vijayawada, IN); Kiran Bhupathiraju (Vijayawada, IN); Venkata Krishna Raju Alluri (Vijayawada, IN)
A61K36/28A61K9/0056A61K9/0095A61K36/185A61K36/19A61K36/42A61K36/48A61K36/53A61K36/61A61K36/71A61K36/75A61K36/8962A61P1/16
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Quick Facts
Patent No.
US 11,071,764
App. No.
16/462,415
Granted
Jul 27, 2021
Kind
B2
Abstract

The invention discloses synergistic compositions comprising at least one component selected from extract(s) and fraction(s) or mixtures thereof derived from Sphaeranthus indicus in combination with at least one component selected from extract(s), fraction(s), active compound(s) or mixtures thereof derived from Terminalia chebula for improving the liver health. The invention further discloses method of improving the liver health in humans and animals by administering the compositions comprising at least one component selected from extract(s) and fraction(s) or mixtures thereof derived from Sphaeranthus indicus in combination with at least one component selected from extract(s), fraction(s), active compound(s) or mixtures thereof derived from Terminalia chebula.

Claims (40)

1. An herbal composition for protecting the liver, improving liver health or treating a diseased liver in humans and animals, comprising:

an effective amount of an extract of Sphaeranthus indicus , and

an effective amount of an extract of Terminalia chebula,

wherein the extract of Sphaeranthus indicus and the extract of Terminalia chebula are present in a ratio ranging from 1:3 to 3:1.

2. The herbal composition of claim 1 , further comprising:

at least one biologically active natural ingredient selected from the group consisting of an anti-oxidant, an anti-inflammatory agent, an immunomodulating agent;

a pharmaceutically acceptable active ingredient;

a vitamin;

a mineral;

a pharmaceutically, nutraceutically, or dietically acceptable excipient, carrier, or diluent; or

a mixture thereof.

3. The herbal composition of claim 2 , wherein the pharmaceutically or dietetically acceptable excipients, carriers and diluents is selected from the group consisting of glucose, fructose, sucrose, maltose, yellow dextrin, white dextrin, aerosil, microcrystalline cellulose, calcium stearate, magnesium stearate, sorbitol, stevioside, corn syrup, lactose, citric acid, tartaric acid, malic acid, succinic acid, lactic acid, L-ascorbic acid, dl-alpha-tocopherol, glycerin, propylene glycol, glycerin fatty ester, poly glycerin fatty ester, sucrose fatty ester, sorbitan fatty ester, propylene glycol fatty ester, acacia, carrageenan, casein, gelatin, pectin, agar, vitamin B group, nicotinamide, calcium pantothenate, amino acids, proteins, calcium salts, pigments, flavors, preservatives, distilled water, saline, aqueous glucose solution, alcohol, propylene glycol and polyethylene glycol, a vegetable oil, an animal oil, white soft paraffin, paraffin, flavorants, colourants, wax, and a mixture thereof.

4. The herbal composition of claim 1 , further comprising an agent useful for liver protection, improving liver health and treating liver diseases,

wherein the agent useful for liver protection, improving liver health and treating liver diseases is selected from the group consisting of extracts of Aegle marmelos, Allium sativum, Andrographis paniculata, Curcuma longa , Oscimum sanctum, Phyllanthus amarus, Silybum marianum (milk thistle), Tephrosia purpurea, Tinospora sinensis , and mixtures thereof.

5. The herbal composition of claim 1 , wherein:

the extract of Sphaeranthus indicus is prepared from a Sphaeranthus indicus plant part, the Sphaeranthus indicus plant part being selected from the group consisting of a fruit, a flower head, a flower, a rind, a seed, leaves, stems, bark, a whole plant, aerial parts of the plant, and mixtures thereof.

6. The herbal composition of claim 1 , wherein:

the extract of Terminalia chebula is prepared from a Terminalia chebula plant part, the Terminalia chebula plant part being selected from the group consisting of a fruit, a flower head, a flower, a rind, a seed, leaves, stems, bark, a whole plant, aerial parts of the plant, and mixtures thereof.

7. The herbal composition of claim 5 , wherein the extract of Sphaeranthus indicus is prepared by extracting the Sphaeranthus indicus plant part with a solvent selected from the group consisting of a C1-C5 alcohols; ketones; chlorinated solvents; water;

C1-C7 hydrocarbons; esters; and mixtures thereof.

8. The herbal composition of claim 6 , wherein the extract of Terminalia chebula is prepared by extracting the Terminalia chebula plant part with a solvent selected from the group consisting of a C1-C5 alcohols; ketones; chlorinated solvents; water; C1-C7 hydrocarbons; esters; and mixtures thereof.

9. The herbal composition of claim 7 , wherein the extract of Sphaeranthus indicus is prepared by extracting the Sphaeranthus indicus plant part with a solvent selected from the group consisting of ethanol, methanol, n-propanol, isopropyl alcohol, acetone, methyl isobutyl ketone, methylene dichloride, chloroform, water, hexane, ethyl acetate, and mixtures thereof.

10. The herbal composition of claim 8 , wherein the extract of Terminalia chebula is prepared by extracting the Terminalia chebula plant part with a solvent selected from the group consisting of ethanol, methanol, n-propanol, isopropyl alcohol, acetone, methyl isobutyl ketone, methylene dichloride, chloroform, water, hexane, ethyl acetate, and mixtures thereof.

11. A dosage form comprising the herbal composition as claimed in claim 1 , wherein the dosage form is selected from the group consisting of a dry powder, a liquid, a beverage, a food product, a dietary supplement, a tablet, a capsule, a soft chewable form, and a gummy candy.

12. The herbal composition as claimed in claim 1 , wherein the herbal composition is formulated into:

a solid food selected from the group consisting of a chocolate bar and a nutritional bar;

a semisolid food selected from the group consisting of a cream, a jam, and a gel;

a beverage; or

a lactic acid bacteria beverage.

13. The herbal composition as claimed in claim 1 , wherein the extract of Sphaeranthus indices is an organic solvent extract containing:

from 12 to 30% 7-hydroxyfrullanolide, based on an analysis by HPLC; or

from 1 to 10% total chlorogenic acids, based on an analysis by HPLC.

14. The herbal composition as claimed in claim 1 , wherein the extract of Terminalia chebula contains:

20% to 80% total polyphenols, based on an analysis by UV spectroscopy; or

at least one of:

1 to 6% total chebulagic acids;

1-12% total chebulinic acid;

1 to 10% ellagic acid; and

1 to 10% gallic acid,

based on an analysis by HPLC.

Assignments (1)
CHANGE OF NAME Recorded Aug 18, 2025
From: LAILA NUTRACEUTICALS
To: LAILA NUTRA PRIVATE LIMITED
Reel/Frame 072508/0229 →
Priority Claims (1)
IN 201641035885 · Nov 20, 2016 · national
Continuity (1)
Related Publication 20190365839A1 · Dec 5, 2019