Method and system enabling photoplethysmograph measurement of volume status
View Patent ↗A method enables photoplethysmograph measurement of volume status. The method includes the steps of converting photoplethysmograph voltages to volume measurements and characterizing a local microcirculation as a microcosm in a manner allowing a photoplethysmograph to facilitate noninvasive monitoring of systemic status.
1. A microprocessor implemented method for photoplethysmograph measurement of volume status and changes, comprising:
measuring, at a monitoring site, a DC component of a photoplethysmographic signal;
measuring, at a monitoring site, changes resulting from changes in cardiac ejection of pulse as indicated by stroke volume, cardiac output, blood pressure or pulsatile component of a peripheral monitor;
comparing changes in the DC component to changes resulting from changes in cardiac ejection of pulse as indicated by stroke volume, cardiac output, blood pressure or pulsatile component of a peripheral monitor to provide a ratio;
applying the ratio to noninvasively provide a measure of relative values and changes thereof in preload to and blood ejection by the heart to quantify changes in pulsatile and non-pulsatile volume status of a local microcirculation to assess changes in local volume;
establishing cutoffs for clinically meaningful positive and negative responses to a challenge or intervention based upon SV assessment/DC measurement ratio and ΔSV assessment/ΔDC measurement ratio;
assigning values to quadrant of one of a series of SV assessment/DC measurement and ΔSV assessment/ΔDC measurement quadrant maps; and
monitoring systemic vessel physiology, pharmacology, cardiac function, and blood volume based upon the measure of relative values and changes thereof in preload to and blood ejection by the heart to identify and monitor conditions of altered volume and guide treatment of vessel physiology cardiac function, or blood volume.
2. The method according to claim 1 , wherein the DC component is measured in AC rest Mults.
3. The method according to claim 1 , wherein the DC component is measured in ml PPG .
4. The method according to claim 1 , wherein the DC component is normalized to a baseline value of the DC component.
5. The method according to claim 1 , further including the step of quantifying a change in blood ejection by the heart with a measure of respiration-induced variation.
6. The method according to claim 5 , wherein the measure of respiration-induced variation is the perfusion index.
7. The method according to claim 5 , wherein the measure of respiration-induced variation is the pleth variability index.
8. The method according to claim 1 , further including the step of eliminating AC component of the photoplethysmographic signal which includes filtering oscillations at >0.5 Hz from the photoplethysmographic signal.
9. A microprocessor implemented method for photoplethysmograph measurement of volume status and changes, comprising:
measuring, at a monitoring site, oscillatory changes in a DC component of a photoplethysmographic signal;
measuring, at a monitoring site, changes resulting from changes in cardiac ejection of pulse as indicated by stroke volume, cardiac output, blood pressure or pulsatile component of a peripheral monitor;
comparing oscillations in the DC component to changes in cardiac ejection of pulse as indicated by stroke volume, cardiac output, blood pressure or pulsatile component of a peripheral monitor to provide a ratio that noninvasively provides a measure of oscillations in preload to changes in blood ejection by the heart;
establishing cutoffs for clinically meaningful positive and negative responses to a challenge or intervention based upon SV assessment/DC measurement ratio and ΔSV assessment/ΔDC measurement ratio;
assigning values to quadrant of one of a series of SV assessment/DC measurement and ΔSV assessment/ΔDC measurement quadrant maps; and
monitoring systemic vessel physiology, pharmacology, cardiac function, and blood volume based upon the measure of oscillations in preload to changes in blood ejection by the heart to identify and monitor hypovolemic conditions.
10. The method according to claim 9 , wherein the oscillations in the DC component are due to respiration.
11. The method according to claim 9 , wherein the oscillations in the DC component are quantified in time-domain.
12. The method according to claim 9 , wherein the oscillations in the DC component are quantified in spectral domain.
13. The method according to claim 9 , wherein frequency bands within the DC component of a photoplethysmographic signal are isolated to selectively assess impact of respiration.
14. The method according to claim 9 , wherein frequency bands within the DC component of a photoplethysmographic signal are isolated to selectively assess impact of autonomic activity.
15. The method according to claim 9 , further including the step of quantifying the change in blood ejection by the heart with a measure of respiration-induced variation.
16. The method according to claim 15 , wherein the measure of respiration-induced variation is the pleth variability index.
17. The method according to claim 9 , further including the step of eliminating AC component of the photoplethysmographic signal which includes filtering oscillations at >0.5 Hz from the photoplethysmographic signal.
18. A microprocessor implemented method for photoplethysmograph measurement of volume status and changes, comprising:
measuring, at a monitoring site, a DC component of a photoplethysmographic signal and a AC component of photoplethysmographic signal;
determining a baseline, estimated baseline or a preintervention value of the DC component;
determining a baseline, estimated baseline or a preintervention value of the AC component;
establishing cutoffs for clinically meaningful positive and negative responses to a challenge or intervention based upon SV assessment/DC measurement ratio and ΔSV assessment/ΔDC measurement ratio;
assigning values to quadrant of one of a series of SV assessment/DC measurement and ΔSV assessment/ΔDC measurement quadrant maps; and
wherein conditions of altered volume and guide treatment of vessel physiology, cardiac function, or blood volume are identified and monitored by comparing a difference in the DC component from the baseline, estimated baseline or preintervention value to a difference in the AC component from the baseline, estimated baseline or its preintervention value to identify and monitor conditions of altered volume and guide treatment of vessel physiology, cardiac function, or blood volume.
19. The method according to claim 18 , wherein measurements are taken at multiple sites.
20. The method according to claim 19 , wherein a change in the difference in the AC component in association with the difference in DC component is compared to change at a different monitoring site.
21. The method according to claim 18 , wherein a change in the difference in the AC component in association with the difference in DC component is compared to change of measure of cardiac pulsatile ejection.
22. The method according to claim 21 , wherein a relative decline in the AC component at a given site is an indication of local volumetric autoregulation.