Binge behavior regulators

1. A method of regulating binge behavior, the method comprising administrating to a subject in need thereof a compound represented by Formula I:

wherein:

each of R 1 and R 2 is independently selected from the group consisting of H, (C 1 -C 8 )alkyl, (C 2 -C 4 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 8 )cycloalkyl, aryl, heteroaryl, heteroalicyclic, —O(C 1 -C 6 )alkyl, OH, —OS(═O) 2 CF 3 , —OS(═O) 2 —(C 1 -C 6 )alkyl, —S(═O)R 5 , —CO 2 R 5 , —CONR 5 R 6 , —COR 5 , —CF 3 , CN, —SR 5 , —SO 2 NR 5 R 6 , —SO 2 R 5 , —OCO—(C 1 -C 6 )alkyl, —NCO—(C 1 -C 6 )alkyl, —CH 2 O—(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkyl-OH, and halogen, or, alternatively, R 1 and R 2 together with two or more of the phenyl carbon atoms form a X 1 —(CR 5 R 6 ) m —X 2 — ring, wherein each of X 1 and X 2 is independently selected from O, NH or S and m is 1, 2, 3, or 4;

each of R 3 and R 4 is independently selected from the group consisting of H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 2 -C 8 )alkynyl, (C 3 -C 8 ) cycloalkyl, and —(CH 2 ) p -thienyl, wherein p is 1, 2, 3, or 4, or alternatively, R 3 and R 4 are joined together to form a heterocylic ring (heteroalicyclic or heteroaryl) containing the nitrogen atom to which they are attached; and

each of R 5 and R 6 is independently selected from the group consisting of H, (C 1 -C 8 )alkyl, (C 2 -C 8 )alkenyl, (C 3 -C 8 )cycloalkyl and aryl,

thereby regulating the binge behavior,

wherein at least one of R 3 and R 4 is H, and wherein the compound of Formula I is selected from:

5-methoxy-2-aminoindan;

5,6-dimethoxy-2-aminoindan;

5-methoxy-2-(N-propylamino)indan;

5,6-dimethoxy-2-(N-propylamino)indan; 5-(trifluoromethylsulfonyloxy)-2-(N-propylamino)indan;

5,6-(di-trifluoromethylsulfonyloxy)-2-(N-propylamino)Indan; and

5,6-dimethoxy-2(pyrrolidino)indan.

2. The method of claim 1 , wherein said binge behavior is associated with alcohol consumption, eating, tobacco consumption, shopping or sexual conduct.

3. The method of claim 2 , wherein said binge behavior is binge drinking.

4. The method of claim 1 , wherein said compound forms a part of a composition, which further comprises a pharmaceutically acceptable carrier.

5. The method of claim 4 , wherein said composition is in a form of a free-flowing powder, a tablet, a capsule, a lozenge, a liquid, a liquid concentrate or a syrup.

6. The method of claim 4 , wherein said composition is a unit dosage form composition.

7. The method of claim 6 , wherein an amount of said compound in said unit dosage form ranges from 30 mg to 130 mg.

8. The method of claim 7 , wherein said amount of said compound is 70 mg.

9. The method of claim 1 , wherein said compound or composition is administered to a subject orally.

10. The method of claim 1 , wherein the compound of Formula I is 5-methoxy-2-aminoindan.

11. A pharmaceutical composition comprising 5-methoxy-2-aminoindan,

the composition being formulated for oral administration, and being a liquid unit dosage form composition.

12. The pharmaceutical composition of claim 11 , being packaged as a single unit dose or as a plurality of single unit doses.

13. The pharmaceutical composition of claim 11 , wherein said unit dosage form comprises from 30 mg to 130 mg of said compound.