Carbohydrate-binding small molecules with antiviral activity
Compounds with anti-viral properties are provided that are based on the following structures: A variety of heteroaromatic groups have been found to be biologically active against the Zika (ZIKV) virus. In some embodiments, a dimeric compound is provided with each monomer linked by a repeating glycol linking group.
1. A method for treating a human for a Zika (ZIKV) virus infection, the method comprising
administering a synthetic carbohydrate receptor (SCR) to the human, wherein the synthetic carbohydrate receptor (SCR) has a structure of:
wherein Het is a heteroaromatic group selected from 2-pyrrole, 3-pyrrole, 2-pyridine, 3-pyridine, 2-indol, 3-indole, 2-thiophene, 2-furan, N-methyl-2-imidazole and 2-phenol.
2. The method as recited in claim 1 , further comprising diagnosing the human as being infected with the Zika (ZIKV) virus and subsequently performing the step of administering.
3. The method as recited in claim 1 , wherein the heteroaromatic group is selected from 2-pyrrole, 3-pyrrole, 2-pyridine and 3-pyridine.
4. The method as recited in claim 1 , wherein the heteroaromatic group is selected from 2-pyrrole and 3-pyrrole.
5. The method as recited in claim 1 , wherein the heteroaromatic group is selected from 2-pyridine and 3-pyridine.
6. The method as recited in claim 1 , wherein the heteroaromatic group is selected from 2-indole and 3-indole.
7. The method as recited in claim 1 , wherein the heteroaromatic group is selected from 2-thiophene and 2-furan.
8. The method as recited in claim 1 , wherein the heteroaromatic group is N-methyl-2-imidazole.
9. The method as recited in claim 1 , wherein the heteroaromatic group is 2-phenol.
10. A composition of matter comprising a synthetic carbohydrate receptor (SCR) with a structure of:
wherein Het is a heteroaromatic group selected from 3-pyrrole, 2-pyridine, 3-pyridine, 2-indol, 3-indole, 2-thiophene, 2-furan, N-methyl-2-imidazole and 2-phenol.
11. A composition of matter comprising a synthetic carbohydrate receptor (SCR) with a structure of:
wherein Het is 2-pyrrole.
12. A method for treating a human for a Zika (ZIKV) virus infection, the method comprising
administering the synthetic carbohydrate receptor (SCR) of claim 11 to the human.
13. A composition of matter comprising a synthetic carbohydrate receptor (SCR) with a structure of:
wherein n=1, 2 or 3 and X is NH or O.
14. The composition of matter as recited in claim 10 , wherein Het is 2-indole or 3-indole.
15. The composition of matter as recited in claim 10 , wherein Het is 3-indole.
16. A method for treating a human for a Zika (ZIKV) virus infection, the method comprising
administering the synthetic carbohydrate receptor (SCR) of claim 15 to the human.
17. A method for treating a human for a virus infection, the method comprising
administering the synthetic carbohydrate receptor (SCR) of claim 14 to the human.
18. A method for treating a human for a Zika (ZIKV) virus infection, the method comprising
administering the synthetic carbohydrate receptor (SCR) of claim 13 to the human.