Methods and medicaments for the treatment of renal cell carcinoma
The present disclosure is directed, among other things, to the surprising and unexpected efficacy provided by select V 2 R antagonists in significantly reducing the cell proliferation levels of clear cell renal cell carcinoma. Thus, the present disclosure provides methods, uses, and medicaments that include such select V 2 R antagonists for utility in treating clear cell renal cell carcinoma.
1. A method of treating a subject suffering from clear cell renal cell carcinoma, the method comprising
administering to the subject an effective amount of a compound selected from OPC31260, OPC41061, a pharmaceutically acceptable salt of either thereof, or a mixture of any two or more thereof;
wherein the effective amount is an amount effective for treating clear cell renal cell carcinoma.
2. The method of claim 1 , wherein the administration comprises oral administration or parenteral administration.
3. The method of claim 1 , wherein the administration comprises at least one of subcutaneous administration, intramuscular administration, intravenous administration, intraperitoneal administration, and oral administration.
4. The method of claim 1 , wherein the subject is a human, a bovine, an equine, a canine, a feline, a simian, a porcine, an ovine, an avian, or a rodent.
5. The method of claim 1 , wherein the subject is a human.
6. The method of claim 1 , wherein the method comprises administering to the subject about 1 mg to about 150 mg of the compound per kilogram of the subject.
7. The method of claim 1 , wherein the method comprises administering the compound to the subject from about 1 to about 7 times per week.
8. The method of claim 1 , wherein a pharmaceutical composition comprises the compound and a pharmaceutically acceptable carrier.
9. The method of claim 8 , wherein the pharmaceutical composition is formulated for oral administration or parenteral administration.
10. The method of claim 8 , wherein the pharmaceutical composition is formulated for at least one of subcutaneous administration, intramuscular administration, intravenous administration, intraperitoneal administration, and oral administration.
11. The method of claim 1 , wherein the clear cell renal cell carcinoma comprises one or more of VHL mutant clear cell renal cell carcinoma and VHL wildtype clear cell renal cell carcinoma.
12. The method of claim 2 , wherein the clear cell renal cell carcinoma comprises one or more of VHL mutant clear cell renal cell carcinoma and VHL wildtype clear cell renal cell carcinoma.
13. The method of claim 3 , wherein the clear cell renal cell carcinoma comprises one or more of VHL mutant clear cell renal cell carcinoma and VHL wildtype clear cell renal cell carcinoma.
14. The method of claim 4 , wherein the clear cell renal cell carcinoma comprises one or more of VHL mutant clear cell renal cell carcinoma and VHL wildtype clear cell renal cell carcinoma.
15. The method of claim 5 , wherein the clear cell renal cell carcinoma comprises one or more of VHL mutant clear cell renal cell carcinoma and VHL wildtype clear cell renal cell carcinoma.
16. The method of claim 6 , wherein the clear cell renal cell carcinoma comprises one or more of VHL mutant clear cell renal cell carcinoma and VHL wildtype clear cell renal cell carcinoma.
17. The method of claim 7 , wherein the clear cell renal cell carcinoma comprises one or more of VHL mutant clear cell renal cell carcinoma and VHL wildtype clear cell renal cell carcinoma.
18. The method of claim 8 , wherein the clear cell renal cell carcinoma comprises one or more of VHL mutant clear cell renal cell carcinoma and VHL wildtype clear cell renal cell carcinoma.
19. The method of claim 9 , wherein the clear cell renal cell carcinoma comprises one or more of VHL mutant clear cell renal cell carcinoma and VHL wildtype clear cell renal cell carcinoma.
20. The method of claim 10 , wherein the clear cell renal cell carcinoma comprises one or more of VHL mutant clear cell renal cell carcinoma and VHL wildtype clear cell renal cell carcinoma.