Compositions and methods for treating depression
Disclosed is a therapeutic regimen which includes S-adenosyl methionine, or a salt thereof; folic acid, or a metabolite therof, or a salt thereof; and a compound of Formula (I), or salt thereof, useful in the treatment of a variety of conditions, e.g., neuropsychiatric conditions such as depression. The therapeutic regimen may be used in combination with therapeutic agents as described here.
1. A method of treating a neuropsychiatric condition, or for promoting wellness and/or energy, the method comprising administering an effective amount of S-adenosyl methionine (SAMe), or a salt thereof; methyl folate, or a salt thereof; and a compound of Formula (I):
or a salt thereof, wherein:
R is hydrogen or —C(═O)R A , wherein R A is unsubstituted C 10-18 alkyl; and
—C(═O)R B is of the formula:
to a subject in need thereof.
2. The method of claim 1 , wherein the compound of Formula (I) is of the formula:
or a salt thereof.
3. The method of claim 1 , wherein the compound of Formula (I), or salt thereof, is provided in a range of between about 50 mg to about 1000 mg, inclusive.
4. The method of claim 1 , wherein S-adenosyl methionine, or a salt thereof, is provided in a range of between about 200 mg to about 2000 mg, inclusive.
5. The method of claim 1 , wherein methyl folate, or a salt thereof, is provided in a range of between about 1 mg to about 45 mg, inclusive.
6. The method of claim 1 , further comprising administering one or more omega-3 fatty acids, or salts thereof.
7. The method of claim 6 , wherein one or more omega-3 fatty acids, or salts thereof, is provided in a range of between about 500 mg to about 5 g, inclusive.
8. The method of claim 6 , wherein the one or more omega-3 fatty acids, or salts thereof, comprises at least 50% EPA.
9. The method of claim 1 , further comprising administering vitamin D3.
10. The method of claim 9 , wherein the vitamin D3 is provided in a range of about 500 IU to about 2000 IU, inclusive.
11. The method of claim 1 , further comprising administering vitamin B 12.
12. The method of claim 1 , wherein S-adenosyl methionine (SAMe), or a salt thereof; methyl folate, or a salt thereof; and a compound of Formula (I), or a salt thereof, are each administered separately in different compositions.
13. The method of claim 1 , wherein S-adenosyl methionine (SAMe), or a salt thereof; methyl folate, or a salt thereof; and a compound of Formula (I), or a salt thereof, are administered together in the same composition.
14. The method of claim 1 , wherein the neuropsychiatric condition is selected from mood disorders or conditions characterized by atypical mood.
15. The method of claim 14 , wherein the mood disorders are selected from the group consisting of depression, Bipolar Disorder, and Anxiety Disorder.
16. The method of claim 15 , wherein the depression is Major Depressive Disorder.
17. The method of claim 14 , wherein the condition characterized by atypical mood is selected from the group consisting of stress, hormonal mood swings, Mild Cognitive Impairment, substance-induced mood disorders, dementia, Alzheimer's disease, Parkinson's disease, Huntington's disease, and psychotic disorders.
18. The method of claim 17 , wherein the hormonal mood swings are mood swings during pregnancy, during post-partum, during puberty, or during menopause, or are a result of a Premenstrual Dysphoric Disorder condition.
19. The method of claim 17 , wherein the psychotic disorder is selected from the group consisting of Schizoaffective Disorder, Schizophrenia, Delusional Disorder, and Psychotic Disorder Not Otherwise Specified.
20. The method of claim 1 , wherein the method is for treating depression.
21. The method of claim 1 , wherein the compound of Formula (I), or salt thereof, is provided in a range of between about 100 mg to about 500 mg, inclusive.