Fixed dose combinations and formulations comprising ETC1002 and one or more statins and methods of treating or reducing cardiovascular disease
Disclosed herein are compositions comprising fixed doses of ETC-1002 and one or more statins. Also disclosed herein are methods for using fixed doses of ETC-1002 and one or more statins. Uses include methods of treating cardiovascular disease or reducing the risk of cardiovascular disease in a subject. Uses also include methods of treating hypercholesterolemia in a subject.
1. A fixed-dose composition comprising ETC-1002 and one or more statins selected from the group consisting of rosuvastatin and atorvastatin, wherein
the fixed dose of ETC-1002 is 180 mg,
the fixed dose of rosuvastatin is 20-40 mg,
the fixed dose of atorvastatin is 40-80 mg, and
administration of the fixed-dose composition results in an equal or decreased frequency of myalgia compared to the administration of the fixed dose of the one or more statins.