Medical device comprising boswellic acid
A medical composition and devices made from the composition for the delivery of extracts obtained from Boswellia genus, similar compounds synthetically derived, and in particular derivatives of triterpenes is disclosed. The medical device may be implantable, or alternatively a device which contacts the interior of a mammalian body. The medical device may be comprised, of or present an absorbable component containing Boswellia derivatives, or an eluting component. When administered into a particular body site, the Boswellia component may be released substantially and immediately, released slowly, or not released, into the body and residing actively on the medical device surface.
1. A therapeutic composition comprising:
a multi-armed poloxamer having a plurality of arms bound via an isocyanate group to a hydroxyl group of an acetylated boswellic acid molecule, the polymerization utilizing an isocyanate group, the total weight of acetylated boswellic acid molecules includes at least 20% by weight of 3-acetyl-11-keto-beta boswellic acid and wherein the total weight of acetylated boswellic acid molecules comprises from 1 to 10% by weight of the total composition weight.
2. The composition according to claim 1 , wherein said poloxamer contains two hydroxyl groups.
3. The composition according to claim 1 , wherein said poloxamer contains more than 2 hydroxyl groups.
4. The composition of claim 1 , wherein the acetylated boswellic acid molecule is selected from at least one of β-Boswellic acid; acetyl β-boswellic acid; 11-keto-β bosweliic acid; acetyl 11-keto-β-boswellic acid; 3a-hydroxy urs-9,12-diene-24-oic acid; or 2a, 3a dihydroxy urs-12-ene-24-oic acid.
5. The composition of claim 1 wherein the poloxamer includes blocks configured such that as degradation of the composition occurs, fragments of substantially hydrophobic polymer are not formed.
6. The composition of claim 1 , wherein the composition further comprises a solubilizing agent and a physiologically compatible carrier.
7. The composition of claim 6 , wherein the solubilizing agent is propylene carbonate.
8. The composition of claim 6 , wherein the physiologically compatible carrier is propylene carbonate.
9. A therapeutic composition comprising:
a multi-armed copolymer comprised of polyalkylene glycol blocks and polylactic acid blocks, the copolymer having a plurality of arms bound via an isocyanate group to a hydroxyl group of an acetylated boswellic acid molecule, the total weight of acetylated boswellic acid molecules includes at least 20% by weight of 3-acetyl-11-keto-beta boswellic acid and wherein the total weight of acetylated boswellic acid molecules comprises from 1 to 10% by weight of the total composition weight.
10. The composition according to claim 9 , wherein the copolymer contains two hydroxyl groups.
11. The composition according to claim 9 , wherein the copolymer contains more than 2 hydroxyl groups.
12. The composition of claim 9 , wherein the acetylated boswellic acid molecule is selected from at least one of acetyl β-boswellic acid and acetyl 11-keto-β-boswellic acid.
13. The composition of claim 9 wherein the copolymer includes blocks configured such that as degradation of the composition occurs, fragments of substantially hydrophobic polymer are not formed.
14. The composition of claim 9 , wherein the composition further comprises a solubilizing agent and a physiologically compatible carrier.
15. The composition of claim 14 , wherein the solubilizing agent is propylene carbonate.
16. The composition of claim 14 , wherein the physiologically compatible carrier is propylene carbonate.