TDP-43 mitochondrial localization inhibitor for the treatment of neurogenerative disease
A method of treating a neurodegenerative disease in a subject includes administering to the subject a therapeutically effective amount of a TDP-43 mitochondrial localization inhibitor.
1. A pharmaceutical composition comprising: a therapeutic agent that includes a synthetic therapeutic peptide of about 5 to about 10 amino acids in length that includes the amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 3, and SEQ ID NO: 5 and a transport moiety that is linked to the therapeutic peptide and facilitates uptake of the therapeutic peptides by a cell, wherein the therapeutic peptide inhibits TDP-43 mediated disassembly of mitochondrial respiratory complex 1.
2. The composition of claim 1 , the therapeutic peptide including the amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 7.
3. The composition of claim 1 , the therapeutic peptide including the amino acid sequence of SEQ ID NO: 3 or SEQ ID NO: 8.
4. The composition of claim 1 , the therapeutic peptide including the amino acid sequence of SEQ ID NO: 5 or SEQ ID NO: 9.
5. The composition of claim 1 , the transport moiety comprising a TAT peptide.
6. The composition of claim 1 , the therapeutic agent having the amino acid sequence selected from the group consisting of SEQ ID NOs: 12-17.