Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives

1. A compound of Formula II:

or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, tautomer, or deuterated analogs thereof, wherein:

x, y, and z are independently 1, 2, 3, or 4,

Q is S(O) 2 ;

R 21 is selected from the group consisting of: C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, —NR 33 R 33 , 6-10 membered aryl, 5-10 membered heteroaryl, C 3-12 cycloalkyl, and 4-12 membered heterocyclyl, wherein each C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, 6-10 membered aryl, 5-10 membered heteroaryl, C 3-12 cycloalkyl, and 4-12 membered heterocyclyl are optionally further substituted with one or more R 31 groups;

R 31 is selected from the group consisting of: hydroxyl, oxo, halo, —CN, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, 5-10 membered heteroaryl, —P(O)R 34 R 34 , —S(O)(NH)R 34 , —S(O)(NR 28 )R 34 , —S(O)(NH)NR 33 R 33 , —S(O)(NR 28 )NR 33 R 33 , —SH, —S(O) 0-2 R 34 , —S(O) 1-2 NR 33 R 33 , —SF 5 , —NO 2 , —NR 33 R 33 , —NR 33 SO 2 R 34 , —OS(O) 2 R 34 , —C(O)OR 34 , —C(O)R 34 , —NR 33 C(O)OR 34 , —NR 33 C(O)NR 33 R 33 , —NR 33 S(O) 2 NR 33 R 33 , and —C(O)NR 33 R 33 , wherein each of the C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, and 5-10 membered heteroaryl are optionally substituted with one or more R 29 groups;

each R 29 is independently selected from the group consisting of: —H, oxo, —OH, —CN, halo, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, 5-10 membered heteroaryl, —NR 33 R 33 , —NR 33 C(O)OR 34 , —OS(O) 2 R 34 —C(O)OR 34 , —S(O)(NH)R 34 , —S(O)(NR)R 34 , —S(O)(NH)NR 33 R 33 , —S(O)(NR 28 )NR 33 R 33 , —S(O) 0-2 R 34 , —S(O) 1-2 NR 33 R 33 , —C(O)NR 33 R 33 , —NR 33 SO 2 R 34 , —C(O)R 34 , —NR 33 C(O)NR 33 R 33 , —NR 33 S(O) 2 NR 33 R 33 , —SF 5 , and —NO 2 , wherein each of the C 1-6 alkyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, and 5-10 membered heteroaryl is optionally substituted with one or more R 36 ;

each R 33 is independently selected from the group consisting of —H, C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, C 3-6 cycloalkyl, 6-10 membered aryl, 4-12 membered heterocyclyl and 5-10 membered heteroaryl, wherein the C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-6 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl and 5-10 membered heteroaryl are optionally substituted with one or more R 35 groups;

each R 34 is independently selected from the group consisting of: C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, C 3-6 cycloalkyl, 6-10 membered aryl, 4-12 membered heterocyclyl and 5-10 membered heteroaryl, wherein the C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-6 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl and 5-10 membered heteroaryl are optionally substituted with one or more R 35 groups;

each R 35 is independently selected from the group consisting of: —H, halo, —CN, —OH, oxo, —NO 2 , —SF 5 , C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, 5-10 membered heteroaryl, —S(O)(NH)R 36 , —S(O)(NR 28 )R 36 , —S(O)(NH)NR 36 R 36 , —S(O)(NR 28 )NR 36 R 36 , —S(O) 0-2 R 36 , —S(O) 2 NH 2 , —NH 2 , —S(O) 2 NR 36 R 36 , C(O)R 36 , —C(O)NR 36 R 36 and C(O)OR 36 , wherein said 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, and 5-10 membered heteroaryl is optionally substituted with one or more R 36 groups;

each R 36 is independently selected from halo, —CN, —OH, —NH 2 , oxo, —NO 2 , —SF 5 , C 1-3 alkyl, C 1-3 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 hydroxyalkyl, thiohaloalkyl, sulfonylalkyl, sulfonylhaloalkyl, sulfonylcycloalkyl, 3-6 membered cycloalkyl, —C(O)NH 2 and —S(O) 2 NH 2 ;

R 22 is selected from the group consisting of: —H, —CN, —F, —Cl, C 1-3 alkyl, C 1-3 haloalkyl, C 1-3 heteroalkyl, C 1-3 alkoxy and C 1-3 haloalkoxy;

each R 23 and R 24 is independently selected from the group consisting of: —H, halo, —OH, —CN, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, 5-10 membered heteroaryl, —SF 5 , —S(O) 0-2 R 34 , —S(O)(NH)R 34 , —S(O)(NR 28 )R 34 , —S(O)(NH)NR 33 R 33 , —S(O)(NR 28 )NR 33 R 33 , —SH, —NR 33 R 33 , —NR 33 SO 2 R 34 , —NR 33 S(O) 2 NR 33 R 33 , —NR 33 C(O)NR 33 R 33 , —NR 33 C(O)OR 34 , tri-C 1-4 alkylsilyl, —C(O)R 34 , —C(O)OR 34 , —C(O)NR 33 R 33 , and —NO 2 , wherein said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, and 5-10 membered heteroaryl are optionally further substituted with one or more R 29 groups;

wherein R 22 and R 23 , or R 23 and R 24 can optionally join, together with the atoms to which they are attached, to form a 5-6 membered cycloalkyl, a 5-6 membered heterocyclyl, phenyl, or a 5-6 membered heteroaryl, each such cyclic groups respectively fused to the phenyl to which they are attached, and each optionally substituted with one or more R 29 groups;

R 27 is selected from the group consisting of: —H, halo, —CN, oxo, —OH, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, tri-C 1-4 alkylsilyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, —S(O) 0-2 R 34 , —S(O)(NH)R 34 , —S(O)(NR 28 )R 34 , —S(O)(NH)NR 33 R 33 , —S(O)(NR 28 )NR 33 R 33 , —NR 33 R 33 , —P(O)R 34 R 34 , —C(O)OH, —C(O)OR 34 , —C(O)NR 33 R 33 , —S(O) 2 NR 33 R 33 , —C(O)R 34 , 6-10 membered aryl, 5-10 membered heteroaryl, and 4-12 membered heterocyclyl; wherein each of said 4-12 membered heterocyclyl, 6-10 membered aryl, 5-10 membered heteroaryl, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, tri-C 1-4 alkylsilyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, and 3-12 membered cycloalkyl is optionally substituted with one or more R 35 ;

R 28 is selected from the group consisting of: C 1-6 alkyl, —C(O)R 34 , 3-12 membered cycloalkyl, C 1-6 heteroalkyl, 6-10 membered aryl, 5-10 membered heteroaryl, 4-12 membered heterocyclyl, —C(O)OR 34 —C(O)NR 33 R 33 , and —SO 2 R 34 , wherein each of the C 1-6 alkyl, 3-12 membered cycloalkyl, C 1-6 heteroalkyl, 6-10 membered aryl, 5-10 membered heteroaryl, 4-12 membered heterocyclyl is optionally substituted with halo, —CN, oxo, hydroxyl, C 1-6 alkyl, C 1-6 alkoxy, —S(O) 1-2 R 34 , —S(O) 2 NR 33 R 33 , —NO 2 , —SF 5 , C 1-6 haloalkyl, C 1-6 haloalkoxy, C 1-6 hydroxyalkyl, —NR 33 R 33 , —C(O)OR 34 , C 1-6 heteroalkyl, 3-6 membered cycloalkyl optionally substituted with one or more R 36 , 4-12 membered heterocyclyl optionally substituted with one or more R 36 , 6-10 membered aryl optionally substituted with one or more R 36 , or 5-10 membered heteroaryl optionally substituted with one or more R 36 ;

subject to the provisos that:

(i) when x+y+z is 6 to 10, and both R 23 and R 27 are H, then R 24 is selected from the group consisting of: C 7-12 cycloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 4-membered heterocyclyl, 7-membered heterocyclyl, 7-12 membered monocyclic heterocyclyl, —SF 5 , —NR 33 R 33 , —NR 33 C(O)OR 34 , —NR 33 SO 2 R 34 , —NR 33 S(O) 2 NR 33 R 33 , —NR 33 C(O)NR 33 R 33 , tri-C 1-4 alkylsilyl, —C(O)R 34 , —C(O)OR 34 , —C(O)NR 33 R 33 , —S(O) 0-2 R 34 , —S(O)(NH)R 34 , —S(O)(NR 28 )R 34 , —S(O)(NH)NR 33 R 33 , —S(O)(NR 28 )NR 33 R 33 , —SH and —NO 2 , wherein each of the C 7-12 cycloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 4-membered heterocyclyl, 7-membered heterocyclyl and 7-12 membered monocyclic heterocyclyl is optionally substituted with one or more R 29 ; 5-6 membered heterocyclyl is optionally substituted with R 37 ; and 8-10 membered bicyclic heterocyclyl is optionally substituted with one or more R 38 ; and

(ii) when x+y+z is 4 or 5, and R 27 is —H or methyl, R 23 is selected from the group consisting of: halo, —CN, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, 5-10 membered heteroaryl, —SF 5 , —S(O) 0-2 R 34 , —S(O)(NH)R 34 , —S(O)(NR 28 )R 34 , —S(O)(NH)NR 33 R 33 , —S(O)(NR 28 )NR 33 R 33 , —SH, —NR 33 R 33 , —NR 33 SO 2 R 34 , —NR 33 S(O) 2 NR 33 R 33 , —NR 33 C(O)NR 33 R 33 , —NR 33 C(O)OR 34 , tri-C 1-4 alkylsilyl, —C(O)R 34 , —C(O)OR 34 , —C(O)NR 33 R 33 , and —NO 2 , wherein each of the C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, and 5-10 membered heteroaryl is optionally further substituted with one or more R 29 groups;

wherein R 37 is selected from the group consisting of —OH, oxo, —CN, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, 5-10 membered heteroaryl, —S(O) 0-2 R 34 , —NR 33 SO 2 R 34 , —NR 33 S(O) 2 NR 33 R 33 , —NR 33 C(O)NR 33 R 33 , —NR 33 C(O)OR 34 , —C(O)R 34 , —C(O)OR 34 and —C(O)NR 33 R 33 ;

and wherein R 38 is selected from the group consisting of C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, 5-10 membered heteroaryl, —S(O) 0-2 R 34 —NR 33 R 33 , —NR 33 SO 2 R 34 , —NR 33 S(O) 2 NR 33 R 33 , —NR 33 C(O)NR 33 R 33 , —NR 33 C(O)OR 34 , —C(O)R 34 , —C(O)OR 34 and —C(O)NR 33 R 33 .

2. The compound of claim 1 , wherein R 21 is selected from the group consisting of: C 1-6 alkyl, —NR 33 R 33 , 6-10 membered aryl, 5-10 membered heteroaryl, C 3-12 cycloalkyl, and 4-12 membered heterocyclyl, wherein each C 1-6 alkyl, 6-10 membered aryl, 5-10 membered heteroaryl, C 3-12 cycloalkyl, and 4-12 membered heterocyclyl is further substituted with one or more R 31 groups.

3. The compound of claim 1 , wherein R 22 is selected from the group consisting of: —H, —CN, —F, methyl, C 1 haloalkyl, C 1-3 heteroalkyl, methoxy and C 1 haloalkoxy.

4. The compound of claim 3 , wherein R 22 is selected from the group consisting of: —H, —CN, —F, and methyl.

5. The compound of claim 1 , wherein R 24 is selected from the group consisting of: —H, halo, —OH, —CN, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, —SF 5 , —S(O) 0-2 R 34 , —S(O)(NH)R 34 , —S(O)(NR 28 )R 34 , —S(O)(NH)NR 33 R 33 , —S(O)(NR 28 )NR 33 R 33 , —NR 33 R 33 , —NR 33 SO 2 R 34 , —NR 33 S(O) 2 NR 33 R 33 , —NR 33 C(O)NR 33 R 33 , —NR 33 C(O)OR 34 , —C(O)R 34 , —C(O)OR 34 , —C(O)NR 33 R 33 , and —NO 2 , wherein each of the C 1-6 alkyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, and C 1-6 heteroalkyl, is further substituted with one or more R 29 groups.

6. The compound of claim 5 , wherein R 24 is selected from the group consisting of: —H, —F, —Cl, —OH, —CN, S(O) 0-2 R 34 , —C(O)R 34 , —NO 2 , —SF 5 , C 1-6 alkyl, and C 1-6 alkoxy, and wherein said C 1-6 alkyl or C 1-6 alkoxy is optionally substituted with one or more F, and R 34 is selected from the group consisting of C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 hydroxyalkyl, and C 1-6 heteroalkyl, wherein the C 1-6 alkyl, C 3-6 cycloalkyl, C 1-6 hydroxyalkyl, and C 1-6 heteroalkyl, is optionally substituted with one or more R 35 groups, and R 35 is independently selected from the group consisting of halo, —CN and OH.

7. The compound of claim 6 , wherein R 24 is selected from the group consisting of: —H, —F, —Cl, —OH, —CN, —SF 5 , C 1-6 alkyl, and C 1-6 alkoxy, and wherein said C 1-6 alkyl or C 1-6 alkoxy is optionally substituted with one or more —F, and R 34 is a C 1-3 haloalkyl.

8. A compound of Formula III:

or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, tautomer, or deuterated analogs thereof, wherein:

Q is —S(O) 2 —,

R 41 is selected from the group consisting of: C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, —NR 53 R 53 , 6-10 membered aryl, 5-10 membered heteroaryl, C 3-12 cycloalkyl, and 4-12 membered heterocyclyl, wherein each C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, 6-10 membered aryl, 5-10 membered heteroaryl, C 3-12 cycloalkyl, and 4-12 membered heterocyclyl is optionally further substituted with one or more R 51 groups;

R 51 is selected from the group consisting of: hydroxyl, oxo, halo, —CN, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, 5-10 membered heteroaryl, —P(O)R 54 R 54 , —S(O)(NH)R 54 , —S(O)(NR 48 )R 54 , —S(O)(NH)NR 53 R 53 , —S(O)(NR 48 )NR 53 R 53 , —S(O) 0-2 R 54 , —S(O) 1-2 NR 53 R 53 , —SF 5 , —NO 2 , —NR 53 R 53 , —NR 53 SO 2 R 54 , —OS(O) 2 R 54 , —C(O)OR 54 , —C(O)R 54 , —NR 53 C(O)OR 54 , —NR 53 C(O)NR 53 R 53 , —NR 53 S(O) 2 NR 53 R 53 , and —C(O)NR 53 R 53 , wherein each C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, and 5-10 membered heteroaryl is optionally substituted with one or more R 49 groups;

each R 49 is independently selected from the group consisting of: —H, oxo, —OH, —CN, halo, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, 5-10 membered heteroaryl, —NR 53 R 53 , —NR 53 C(O)OR 54 , —OS(O) 2 R 54 —C(O)OR 54 , —S(O)(NH)R 54 , —S(O)(NR 48 )R 54 , —S(O)(NH)NR 53 R 53 , —S(O)(NR 48 )NR 53 R 53 , —S(O) 0-2 R 54 , —S(O) 1-2 NR 53 R 53 , —C(O)NR 53 R 53 , —NR 53 SO 2 R 54 , —C(O)R 54 , —NR 53 C(O)NR 53 R 53 , —NR 53 S(O) 2 NR 53 R 53 , —SF 5 , and —NO 2 , wherein each of the C 1-6 alkyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, and 5-10 membered heteroaryl is optionally substituted with R 56 ;

each R 53 is independently selected from the group consisting of —H, C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, C 3-6 cycloalkyl, 6-10 membered aryl, 4-12 membered heterocyclyl and 5-10 membered heteroaryl, wherein the C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-6 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl and 5-10 membered heteroaryl is optionally substituted with one or more R 55 groups;

each R 54 is independently selected from the group consisting of: C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, C 3-6 cycloalkyl, 6-10 membered aryl, 4-12 membered heterocyclyl and 5-10 membered heteroaryl, wherein the C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-6 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl and 5-10 membered heteroaryl is optionally substituted with one or more R 55 groups;

each R 55 is independently selected from —H, halo, —CN, —OH, oxo, —NO 2 , —SF 5 , C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, 5-10 membered heteroaryl, —S(O)(NH)R 56 , —S(O)(NR 48 )R 56 , —S(O)(NH)NR 56 R 56 , —S(O)(NR 48 )NR 56 R 56 , —S(O) 0-2 R 56 , —S(O) 2 NH 2 , —NH 2 , —S(O) 2 NR 56 R 56 , C(O)R 56 , —C(O)NR 56 R 56 and C(O)OR 56 , wherein said 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, and 5-10 membered heteroaryl is optionally substituted with one or more R 56 groups;

each R 56 is independently selected from the group consisting of: halo, —CN, —OH, —NH 2 , oxo, —NO 2 , —SF 5 , C 1-3 alkyl, C 1-3 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 hydroxyalkyl, thiohaloalkyl, sulfonylalkyl, sulfonylhaloalkyl, sulfonylcycloalkyl, 3-6 membered cycloalkyl, —C(O)NH 2 and —S(O) 2 NH 2 ;

R 42 is selected from the group consisting of: —H, —CN, —F, —Cl, C 1-3 alkyl, C 1-3 haloalkyl, C 1-3 heteroalkyl, C 1-3 alkoxy and C 1-3 haloalkoxy;

each R 43 and R 44 is independently selected from the group consisting of: —H, halo, —OH, —CN, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, 5-10 membered heteroaryl, —SF 5 , —S(O) 0-2 R 54 , —S(O)(NH)R 54 , —S(O)(NR 48 )R 54 , —S(O)(NH)NR 53 R 53 , —S(O)(NR 48 )NR 53 R 53 , —SH, —S(O) 1-2 NR 53 R 53 , —NR 53 R 53 , —NR 53 SO 2 R 54 , —NR 53 S(O) 2 NR 53 R 53 , —NR 53 C(O)NR 53 R 53 , —NR 53 C(O)OR 54 , tri-C 1-4 alkylsilyl, —C(O)R 54 , —C(O)OR 54 , —C(O)NR 53 R 53 , and —NO 2 , wherein said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, and 5-10 membered heteroaryl is optionally further substituted with one or more R 49 groups;

wherein R 42 and R 43 , or R 43 and R 44 optionally join, together with the atoms to which they are attached, to form a 5-6 membered cycloalkyl, a 5-6 membered heterocyclyl, phenyl, or a 5-6 membered heteroaryl, each such cyclic groups respectively fused to the phenyl to which they are attached, and each optionally substituted with one or more R 49 groups;

R 47 is selected from the group consisting of: —H, halo, —CN, —OH, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, tri-C 1-4 alkylsilyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, —S(O) 0-2 R 54 , —S(O)(NH)R 54 , —S(O)(NR 48 )R 54 , —S(O)(NH)NR 53 R 53 , —S(O)(NR 48 )NR 53 R 53 , —SH, —NR 53 R 53 , —P(O)R 54 R 54 , —C(O)OH, —C(O)OR 54 , —C(O)NR 53 R 53 , —S(O) 2 NR 53 R 53 , —C(O)R 54 , 6-10 membered aryl, 5-10 membered heteroaryl, and 4-12 membered heterocyclyl; wherein each of said 4-12 membered heterocyclyl, 6-10 membered aryl, 5-10 membered heteroaryl, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, tri-C 1-4 alkylsilyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, and 3-12 membered cycloalkyl is optionally substituted with one or more R 55 ;

R 48 is selected from the group consisting of: C 1-6 alkyl, —C(O)R 54 , 3-12 membered cycloalkyl, C 1-6 heteroalkyl, 6-10 membered aryl, 5-10 membered heteroaryl, 4-12 membered heterocyclyl, C(O)OR 54 , C(O)NR 53 R 53 , and SO 2 R 54 , wherein each of the C 1-6 alkyl, 3-12 membered cycloalkyl, C 1-6 heteroalkyl, 6-10 membered aryl, 5-10 membered heteroaryl, and 4-12 membered heterocyclyl is optionally substituted with halo, —CN, oxo, hydroxyl, C 1-6 alkyl, C 1-6 alkoxy, —S(O) 1-2 R 54 , —S(O) 2 NR 53 R 53 , —NO 2 , —SF 5 , C 1-6 haloalkyl, C 1-6 haloalkoxy, C 1-6 hydroxyalkyl, —NR 53 R 53 , —C(O)OR 54 , C 1-6 heteroalkyl, 3-6 membered cycloalkyl optionally substituted with R 56 , 4-12 membered heterocyclyl optionally substituted with one or more R 56 , 6-10 membered aryl optionally substituted with one or more R 56 , or 5-10 membered heteroaryl optionally substituted with one or more R 56 ;

subject to the proviso that:

when both R 43 and R 47 are H, then R 44 is selected from the group consisting of: C 7-12 cycloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 4-membered heterocyclyl, 7-membered heterocyclyl, 7-12 membered monocyclic heterocyclyl, —SF 5 , —NR 53 R 53 , —NR 53 C(O)OR 54 , —NR 53 SO 2 R 54 , —NR 53 S(O) 2 NR 53 R 53 , —NR 53 C(O)NR 53 R 53 , tri-C 1-4 alkylsilyl, —C(O)R 54 , —C(O)OR 54 , —C(O)NR 53 R 53 , —S(O) 0-2 R 54 , —S(O)(NH)R 54 , —S(O)(NR 48 )R 54 , —S(O)(NH)NR 53 R 53 , —S(O)(NR 48 )NR 53 R 53 , —SH and —NO 2 , wherein each of the C 7-12 cycloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 4-membered heterocyclyl, 7-membered heterocyclyl and 7-12 membered monocyclic heterocyclyl are optionally substituted with one or more R 49 ; 5-6 membered heterocyclyl is optionally substituted with R 57 ; and 8-10 membered bicyclic heterocyclyl is optionally substituted with one or more R 58 ;

wherein R 57 is selected from the group consisting of: —OH, oxo, —CN, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, 5-10 membered heteroaryl, —S(O) 0-2 R 54 , —NR 53 SO 2 R 54 , —NR 53 S(O) 2 NR 53 R 53 , —NR 53 C(O)NR 53 R 53 , —NR 53 C(O)OR 54 , —C(O)R 54 , —C(O)OR 54 and —C(O)NR 53 R 53 ;

and wherein R 58 is selected from the group consisting of: C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, 5-10 membered heteroaryl, —S(O) 0-2 R 54 , —NR 53 R 53 , —NR 53 SO 2 R 54 , —NR 53 S(O) 2 NR 53 R 53 , —NR 53 C(O)NR 53 R 53 , —NR 53 C(O)OR 54 , —C(O)R 54 , —C(O)OR 54 and —C(O)NR 53 R 53 .

9. The compound of claim 8 , wherein R 47 is selected from the group consisting of —H, halo, —CN, —OH, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, —S(O) 0-2 R 54 , —S(O)(NH)R 54 , —S(O)(NR 48 )R 54 , —S(O)(NH)NR 53 R 53 , —S(O)(NR 48 )NR 53 R 53 , —NR 53 R 53 , —C(O)OH, —C(O)OR 54 , —C(O)NR 53 R 53 , —S(O) 2 NR 53 R 53 , —C(O)R 54 , 6-10 membered aryl, 5-10 membered heteroaryl, and 4-12 membered heterocyclyl; wherein each of said 4-12 membered heterocyclyl, 6-10 membered aryl, 5-10 membered heteroaryl, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, and 3-12 membered cycloalkyl is optionally substituted with one or more R 55 .

10. The compound of claim 8 , wherein R 47 is selected from the group consisting of —H, halo, —CN, —OH, C 1-6 alkyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-6 membered cycloalkyl, —S(O) 0-2 R 54 , —C(O)OH, —C(O)OR 54 , —C(O)NR 53 R 53 , —S(O) 2 NR 53 R 53 , —C(O)R 54 , 6-10 membered aryl, 5-10 membered heteroaryl, and 4-12 membered heterocyclyl; wherein each of said 4-12 membered heterocyclyl, 6-10 membered aryl, 5-10 membered heteroaryl, C 1-6 alkyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, and 3-6 membered cycloalkyl is optionally substituted with one or more R 55 .

11. The compound of claim 8 , wherein R 47 is selected from the group consisting of —H, halo, —CN, —OH, C 1-3 alkyl, C 1-3 alkoxy, C 1-3 hydroxyalkyl, C 1-6 heteroalkyl, and 6-10 membered aryl, wherein each of said 6-10 membered aryl, C 1-3 alkyl, C 1-3 alkoxy, C 1-3 hydroxyalkyl, and C 1-6 heteroalkyl is optionally substituted with one or more R 55 , wherein R 55 is selected from the group consisting of: halo, —CN, —NO 2 , —SF 5 , C 1-3 alkyl, C 1-3 haloalkyl, C 1-6 alkoxy, and C 1-6 haloalkoxy.

12. The compound of claim 8 , wherein R 41 is selected from the group consisting of: C 1-6 alkyl, —NR 53 R 53 , 6-10 membered aryl, 5-10 membered heteroaryl, C 3-12 cycloalkyl, and 4-12 membered heterocyclyl, wherein each C 1-6 alkyl, 6-10 membered aryl, 5-10 membered heteroaryl, C 3-12 cycloalkyl, and 4-12 membered heterocyclyl is further optionally substituted with one or more R 51 groups.

13. The compound of claim 8 , wherein R 51 is selected from the group consisting of: hydroxyl, oxo, halo, —CN, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-6 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, 5-10 membered heteroaryl, —S(O)(NH)R 54 , —S(O)(NR 48 )R 54 , —S(O)(NH)NR 53 R 53 , —S(O)(NR 48 )NR 53 R 53 , —S(O) 0-2 R 54 , —S(O) 1-2 NR 53 R 53 , —SF 5 , —NO 2 , —NR 53 R 53 , —NR 53 SO 2 R 54 , —C(O)OR 54 , —C(O)R 54 , —NR 53 C(O)OR 54 , and —C(O)NR 53 R 53 , wherein each C 1-6 alkyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-6 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, and 5-10 membered heteroaryl is optionally substituted with one or more R 49 groups.

14. The compound of claim 8 , wherein each R 49 is independently selected from the group consisting of: —H, oxo, —OH, —CN, halo, C 1-3 alkyl, C 1-3 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-6 membered cycloalkyl, —NR 53 R 53 , —C(O)OR 54 , —S(O) 0-2 R 54 , —S(O) 1-2 NR 53 R 53 , —C(O)NR 53 R 53 , —NR 53 SO 2 R 54 , —C(O)R 54 , —SF 5 , and —NO 2 , wherein each of the C 1-3 alkyl, C 1-3 alkoxy, 3-6 membered cycloalkyl, is optionally substituted with —CN, or one or more halo.

15. The compound of claim 8 , wherein R 42 is selected from the group consisting of: —H, —CN, —F, methyl, C 1 haloalkyl, C 1-3 heteroalkyl, methoxy and C 1 haloalkoxy.

16. The compound of claim 8 , wherein R 42 is selected from the group consisting of: —H and —F.

17. The compound of claim 8 wherein R 44 is selected from the group consisting of: —H, halo, —OH, —CN, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, —SF 5 , —S(O) 0-2 R 54 , —S(O)(NH)R 54 , —S(O)(NR 48 )R 54 , —S(O)(NH)NR 53 R 53 , —S(O)(NR 48 )NR 53 R 53 , —NR 53 R 53 , —NR 53 SO 2 R 54 , —NR 53 S(O) 2 NR 53 R 53 , —NR 53 C(O)NR 53 R 53 , —NR 53 C(O)OR 54 , —C(O)R 54 , —C(O)OR 54 , —C(O)NR 53 R 53 , and —NO 2 , wherein each C 1-6 alkyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, and C 1-6 heteroalkyl is further substituted with one or more R 49 groups.

18. The compound of claim 8 , wherein R 44 is selected from the group consisting of: —H, —F, —Cl, —OH, —CN, —S(O) 0-2 R 54 , —NO 2 , —SF 5 , C 1-6 alkyl, and C 1-6 alkoxy, and wherein said C 1-6 alkyl or C 1-6 alkoxy is optionally substituted with one or more —F, and R 54 is selected from the group consisting of C 1-6 alkyl, C 1-6 hydroxyalkyl, and C 1-6 heteroalkyl, wherein the C 1-6 alkyl, C 1-6 hydroxyalkyl, and C 1-6 heteroalkyl, is optionally substituted with one or more R 55 groups, and R 55 is independently selected from halo, —CN, —OH, and oxo.

19. The compound of claim 8 , wherein R 44 is selected from the group consisting of: —H, —F, —Cl, —OH, —CN, —SR 54 , —SF 5 , C 1-6 alkyl, and C 1-6 alkoxy, and wherein said C 1-6 alkyl or C 1-6 alkoxy is optionally substituted with one or more —F, and R 54 is C 1-3 haloalkyl.

20. The compound of claim 8 , wherein R 43 is selected from the group consisting of: —H, halo, —OH, —CN, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, C 3-12 cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, 5-10 membered heteroaryl, —SF 5 , —S(O) 0-2 R 54 , —S(O)(NH)R 54 , —S(O)(NR 48 )R 54 , —S(O)(NH)NR 53 R 53 , —S(O)(NR 48 )NR 53 R 53 , —NR 53 R 53 , —NR 53 SO 2 R 54 , —NR 53 S(O) 2 NR 53 R 53 , —NR 53 C(O)NR 53 R 53 , —NR 53 C(O)OR 54 , —C(O)R 54 , —C(O)OR 54 , —C(O)NR 53 R 53 , and —NO 2 , wherein said C 1-6 alkyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, C 3-12 cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, and 5-10 membered heteroaryl is further substituted with one or more R 49 groups.

21. The compound of claim 8 , wherein R 49 is selected from the group consisting of: —H, oxo, —OH, —CN, halo, C 1-3 alkyl, C 1-3 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-6 membered cycloalkyl, —NR 53 R 53 , —C(O)OR 54 , —S(O) 0-2 R 54 , —S(O) 1-2 NR 53 R 53 , —C(O)NR 53 R 53 , and —C(O)R 54 , wherein each of the C 1-3 alkyl, C 1-3 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, and 3-6 membered cycloalkyl is optionally substituted with —CN or one or more halo.

22. The compound of claim 8 , wherein R 49 is selected from the group consisting of: —H, oxo, —OH, —CN, halo, C 1-3 alkyl, C 1-3 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-6 membered cycloalkyl, —NR 53 R 53 , —C(O)OR 54 , —S(O) 0-2 R 54 , —S(O) 1-2 NR 53 R 53 , —C(O)NR 53 R 53 , and —C(O)R 54 , wherein each of the C 1-3 alkyl, C 1-3 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, and 3-6 membered cycloalkyl is optionally substituted with —CN or one or more halo.

23. The compound of claim 22 , wherein R 49 is selected from the group consisting of: —H, oxo, —OH, —CN, halo, C 1-3 alkyl, C 1-3 alkoxy, C 1-3 hydroxyalkyl, C 1-6 heteroalkyl, 3-6 membered cycloalkyl, —C(O)OR 54 , —S(O) 0-2 R 54 , —S(O) 1-2 NR 53 R 53 , and —C(O)R 54 , wherein each of the C 1-3 alkyl, C 1-3 alkoxy, C 1-3 hydroxyalkyl, C 1-6 heteroalkyl, and 3-6 membered cycloalkyl is optionally substituted with —CN or one or more halo.

24. A compound of Formula IV:

or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, tautomer, or deuterated analogs thereof, wherein:

Q is —S(O) 2 —,

R 61 is selected from the group consisting of: C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, —NR 73 R 73 , 6-10 membered aryl, 5-10 membered heteroaryl, C 3-12 cycloalkyl, and 4-12 membered heterocyclyl, wherein each of the C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, 6-10 membered aryl, 5-10 membered heteroaryl, C 3-12 cycloalkyl, and 4-12 membered heterocyclyl is optionally further substituted with one or more R 71 groups;

R 71 is selected from the group consisting of: hydroxyl, oxo, halo, —CN, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, 5-10 membered heteroaryl, —P(O)R 74 R 74 , —S(O)(NH)R 74 , —S(O)(NR 68 )R 74 , —S(O)(NH)NR 73 R 73 , —S(O)(, NR 68 )NR 73 R 73 , —SH, —S(O) 0-2 R 74 , —S(O) 1-2 NR 73 R 73 , —SF 5 , —NO 2 , —NR 73 R 73 , —NR 73 SO 2 R 74 , —OS(O) 2 R 74 , —C(O)OR 74 , —C(O)R 74 , —NR 73 C(O)OR 74 , —NR 73 C(O)NR 73 R 73 , —NR 73 S(O) 2 NR 73 R 73 , and —C(O)NR 73 R 73 , wherein each of the C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, and 5-10 membered heteroaryl is optionally substituted with one or more R 69 groups;

each R 69 is independently selected from the group consisting of: —H, oxo, —OH, —CN, halo, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, 5-10 membered heteroaryl, —NR 73 R 73 , —NR 73 C(O)OR 74 , —OS(O) 2 R 74 , —C(O)OR 74 , —S(O)(NH)R 74 , —S(O)(NR 68 )R 74 , —S(O)(NH)NR 73 R 73 , S(O)(NR 68 )NR 73 R 73 , —SH, —S(O) 0-2 R 74 , —S(O) 1-2 NR 73 R 73 , —C(O)NR 73 R 73 , —NR 73 SO 2 R 74 , —C(O)R 74 , —NR 73 C(O)NR 73 R 73 , —NR 73 S(O) 2 NR 73 R 73 , —SF 5 , and —NO 2 , wherein each of the C 1-6 alkyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, and 5-10 membered heteroaryl is optionally substituted with one or more R 76 groups;

each R 73 is independently selected from the group consisting of —H, C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, C 3-6 cycloalkyl, 6-10 membered aryl, 4-12 membered heterocyclyl and 5-10 membered heteroaryl, wherein the C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-6 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl and 5-10 membered heteroaryl is optionally substituted with one or more R 75 groups;

each R 74 is independently selected from the group consisting of: C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, C 3-6 cycloalkyl, 6-10 membered aryl, 4-12 membered heterocyclyl and 5-10 membered heteroaryl, wherein the C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-6 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl and 5-10 membered heteroaryl is optionally substituted with one or more R 75 groups;

each R 75 is independently selected from —H, halo, —CN, —OH, oxo, —NO 2 , —SF 5 , C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, 5-10 membered heteroaryl, —S(O)(NH)R 66 , —S(O)(NR 68 )R 66 , —S(O)(NH)NR 66 R 66 , —S(O)(NR 68 )NR 66 R 66 , —SH, —S(O) 0-2 R 66 , —S(O) 2 NH 2 , —NH 2 , —S(O) 2 NR 66 R 66 , —C(O)NR 66 R 66 , and —C(O)OR 66 , wherein each of the 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, and 5-10 membered heteroaryl is optionally substituted with one or more R 76 groups;

each R 76 is independently selected from halo, —CN, —OH, —NH 2 , oxo, —NO 2 , —SF 5 , C 1-3 alkyl, C 1-3 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, C 1-6 hydroxyalkyl, thioalkyl, thiohaloalkyl, thiocycloalkyl, sulfonylalkyl, sulfonylhaloalkyl, sulfonylcycloalkyl, 3-6 membered cycloalkyl, —C(O)NH 2 and —S(O) 2 NH 2 ;

R 62 is selected from the group consisting of: —H, —CN, —F, —Cl, C 1-3 alkyl, C 1-3 haloalkyl, C 1-3 heteroalkyl, C 1-3 alkoxy and C 1-3 haloalkoxy;

each R 63 and R 64 is independently selected from the group consisting of: —H, halo, —OH, —CN, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, 5-10 membered heteroaryl, —SF 5 , —S(O) 0-2 R 74 , —S(O)(NH)R 74 , —S(O)(NR 68 )R 74 , —S(O)(NH)NR 73 R 73 , —S(O)(NR 68 )NR 73 R 73 , —SH, —NR 73 R 73 , —NR 73 SO 2 R 74 , —NR 73 S(O) 2 NR 73 R 73 , —NR 73 C(O)NR 73 R 73 , —NR 73 C(O)OR 74 , tri-C 1-4 alkylsilyl, —C(O)R 74 , —C(O)OR 74 , —C(O)NR 73 R 73 and —NO 2 , wherein said C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, and 5-10 membered heteroaryl is optionally further substituted with one or more R 69 groups;

wherein R 62 and R 63 , or R 63 and R 64 can optionally join, together with the atoms to which they are attached, to form a 5-6 membered cycloalkyl, a 5-6 membered heterocyclyl, phenyl, or a 5-6 membered heteroaryl, each such cyclic groups respectively fused to the phenyl to which they are attached, and each optionally substituted with one or more R 69 groups;

R 67 is selected from the group consisting of: —H, halo, —CN, —OH, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, tri-C 1-4 alkylsilyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-12 membered cycloalkyl, —S(O) 0-2 R 74 , —S(O)(NH)R 74 , —S(O)(NR 68 )R 74 , —S(O)(NH)NR 73 R 73 , —S(O)(NR 68 )NR 73 R 73 , —SH, —NR 73 R 73 , —P(O)R 74 R 74 , —C(O)OH, —C(O)OR 74 , —C(O)NR 73 R 73 , —S(O) 2 NR 73 R 73 , —C(O)R 74 , 6-10 membered aryl, 5-10 membered heteroaryl and 4-12 membered heterocyclyl; wherein each of said 4-12 membered heterocyclyl, 6-10 membered aryl, 5-10 membered heteroaryl, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, tri-C 1-4 alkylsilyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, and 3-12 membered cycloalkyl is optionally substituted with one or more R 75 ;

R 68 is selected from the group consisting of: C 1-6 alkyl, —C(O)R 74 , 3-12 membered cycloalkyl, C 1-6 heteroalkyl, 6-10 membered aryl, 5-10 membered heteroaryl, 4-12 membered heterocyclyl, —C(O)OR 74 , —C(O)NR 73 R 73 , and —SO 2 R 74 , wherein each of the C 1-6 alkyl, 3-12 membered cycloalkyl, C 1-6 heteroalkyl, 6-10 membered aryl, 5-10 membered heteroaryl, and 4-12 membered heterocyclyl is optionally substituted with halo, —CN, oxo, hydroxyl, C 1-6 alkyl, C 1-6 alkoxy, —S(O) 1-2 R 74 , —S(O) 2 NR 73 R 73 , —NO 2 , —SF 5 , C 1-6 haloalkyl, C 1-6 haloalkoxy, C 1-6 hydroxyalkyl, —NR 73 R 73 , —C(O)OR 74 , C 1-6 heteroalkyl, 3-6 membered cycloalkyl optionally substituted with R 76 , 4-12 membered heterocyclyl optionally substituted with one or more R 76 , 6-10 membered aryl optionally substituted with one or more R 76 , or 5-10 membered heteroaryl optionally substituted with one or more R 76 .

25. The compound of claim 24 , wherein R 61 is selected from the group consisting of: C 1-6 alkyl, —NR 73 R 73 , 6-10 membered aryl, 5-10 membered heteroaryl, C 3-12 cycloalkyl, and 4-12 membered heterocyclyl, wherein each of the C 1-6 alkyl, 6-10 membered aryl, 5-10 membered heteroaryl, C 3-12 cycloalkyl, and 4-12 membered heterocyclyl is further substituted with one or more R 71 groups.

26. The compound of claim 24 , wherein R 62 is selected from the group consisting of: —H, —CN, —F, methyl, C 1 haloalkyl, C 1-3 heteroalkyl, methoxy and C 1 haloalkoxy.

27. The compound of claim 26 , wherein R 62 is selected from the group consisting of: —H and —F.

28. The compound of claim 24 , wherein R 64 is selected from the group consisting of: —H, halo, —OH, —CN, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, —SF 5 , —S(O) 0-2 R 74 , —S(O)(NH)R 74 , —S(O)(NR 68 )R 74 , —S(O)(NH)NR 73 R 73 , —S(O)(NR 68 )NR 73 R 73 , —NR 73 R 73 , —NR 73 SO 2 R 74 , —NR 73 S(O) 2 NR 73 R 73 , —NR 73 C(O)NR 73 R 73 , —NR 73 C(O)OR 74 , —C(O)R 74 , —C(O)OR 74 , —C(O)NR 73 R 73 , and —NO 2 , wherein said C 1-6 alkyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, and C 1-6 heteroalkyl is further substituted with one or more R 69 groups.

29. The compound of claim 28 , wherein R 64 is selected from the group consisting of: —H, —F, —Cl, —OH, —CN, —S(O) 0-2 R 74 , —SF 5 , —NO 2 , C 1-6 alkyl, and C 1-6 alkoxy, and wherein said C 1-6 alkyl or C 1-6 alkoxy is optionally substituted with one or more —F and R 74 is selected from the group consisting of C 1-6 alkyl, C 1-6 hydroxyalkyl, and C 1-6 heteroalkyl, wherein the C 1-6 alkyl, C 1-6 hydroxyalkyl, and C 1-6 heteroalkyl, is optionally substituted with one or more R 75 groups, and R 75 is independently selected from the group consisting of: halo, —CN, —OH, and oxo.

30. The compound of claim 29 , wherein R 64 is selected from the group consisting of: —H, —F, —Cl, —OH, —CN, SR 74 , —SF 5 , C 1-6 alkyl, and C 1-6 alkoxy, and wherein said C 1-6 alkyl or C 1-6 alkoxy is optionally substituted with one or more —F, and R 74 is C 1-3 haloalkyl.

31. The compound of claim 24 , wherein R 63 is selected from the group consisting of: —H, halo, —OH, —CN, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, C 3-12 cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, 5-10 membered heteroaryl, —SF 5 , —S(O) 0-2 R 74 , —S(O)(NH)R 74 , —S(O)(NR 68 )R 74 , —S(O)(NH)NR 73 R 73 , —S(O)(NR 68 )NR 73 R 73 , —NR 73 R 73 , —NR 73 SO 2 R 74 , —NR 73 S(O) 2 NR 73 R 73 , —NR 73 C(O)NR 73 R 73 , —NR 73 C(O)OR 74 , —C(O)R 74 , —C(O)OR 74 , —C(O)NR 73 R 73 , and —NO 2 , wherein said C 1-6 alkyl, C 1-6 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, C 3-12 cycloalkyl, 4-12 membered heterocyclyl, 6-10 membered aryl, and 5-10 membered heteroaryl is further substituted with one or more R 69 groups.

32. The compound of claim 24 , wherein R 69 is selected from the group consisting of: —H, oxo, —OH, —CN, halo, C 1-3 alkyl, C 1-3 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, 3-6 membered cycloalkyl, —NR 73 R 73 , —C(O)OR 74 , —S(O) 0-2 R 74 , —S(O) 1-2 NR 73 R 73 , —C(O)NR 73 R 73 , and —C(O)R 74 , wherein each of the C 1-3 alkyl, C 1-3 alkoxy, C 1-6 hydroxyalkyl, C 1-6 heteroalkyl, and 3-6 membered cycloalkyl is optionally substituted with —CN or one or more halo.

33. The compound of claim 31 , wherein R 63 is selected from the group consisting of: —H, halo, —CN, C 1-3 alkyl, C 1-3 alkoxy, C 1-3 hydroxyalkyl, C 1-6 heteroalkyl, C 3-6 cycloalkyl, 4-6 membered heterocyclyl, 5-10 membered heteroaryl, —SF 5 , —S(O) 0-2 R 74 , and —NO 2 , wherein said C 1-3 alkyl, C 1-3 alkoxy, C 1-3 hydroxyalkyl, C 1-6 heteroalkyl, C 3-6 cycloalkyl, 4-6 membered heterocyclyl, and 5-10 membered heteroaryl is further substituted with one or more R 69 groups.

34. The compound of claim 32 , wherein R 69 is selected from the group consisting of: —H, oxo, —OH, —CN, halo, C 1-3 alkyl, C 1-3 alkoxy, C 1-3 hydroxyalkyl, C 1-6 heteroalkyl, 3-6 membered cycloalkyl, —C(O)OR 74 , —S(O) 0-2 R 74 , —S(O) 1-2 NR 73 R 73 , and —C(O)R 74 , wherein each of the C 1-3 alkyl, C 1-3 alkoxy, C 1-3 hydroxyalkyl, C 1-6 heteroalkyl, and 3-6 membered cycloalkyl is optionally substituted with —CN or one or more halo.

35. A compound selected from the group consisting of:

36. A compound selected from the group consisting of:

37. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, tautomer, or deuterated analogs thereof, together with a pharmaceutically acceptable excipient.

38. A pharmaceutical composition comprising a compound of claim 8 , or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, tautomer, or deuterated analogs thereof, together with a pharmaceutically acceptable excipient.

39. A pharmaceutical composition comprising a compound of claim 24 , or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, tautomer, or deuterated analogs thereof, together with a pharmaceutically acceptable excipient.

40. A pharmaceutical composition comprising a compound of claim 35 , or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, tautomer, or deuterated analogs thereof, together with a pharmaceutically acceptable excipient.

41. A pharmaceutical composition comprising a compound of claim 36 , or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, tautomer, or deuterated analogs thereof, together with a pharmaceutically acceptable excipient.

42. A compound selected from the group consisting of:

or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, tautomer, or deuterated analog thereof.

43. A compound selected from the group consisting of:

or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, tautomer, or deuterated analog thereof.