Systems, devices, and methods for controlling the temperature of a CO2 pump
Methodologies, systems, and computer-readable media are provided for controlling the mass flow rate within a CO 2 based chromatography system. The pressure within a CO 2 pump is measured and received at a computing system, and the computing system retrieves a target temperature value corresponding to the new pressure measurement within the CO 2 pump. The computing system then generates a temperature control command that controls a CO 2 pump heater or cooler in order to achieve the target temperature value at the CO 2 pump. Thus, a target mass flow rate of CO 2 from the CO 2 pump is achieved by adjusting the temperature of the CO 2 pump in response to changes in pressure.
1. A method for controlling mass flow rate within a CO 2 -based chromatography system comprising:
measuring a change in pressure within a CO 2 pump using a pressure sensor;
receiving a new pressure measurement at a computing system from the pressure sensor;
retrieving a target temperature value corresponding to the new pressure measurement from a database using the computing system;
generating a temperature control command, using the computing system, the temperature control command configured to control a CO 2 pump heater or cooler in order to achieve the target temperature value at the CO 2 pump; and
maintaining a constant mass flow rate of CO 2 from the CO 2 pump by achieving the target temperature value at the CO 2 pump.
2. The method of claim 1 , wherein the temperature control command is configured to control a temperature of a coolant to the CO 2 pump.
3. The method of claim 1 , wherein the temperature control command is configured to:
pre-cool a solvent within the CO 2 -based chromatography system to a minimum target temperature; and
adjust the CO 2 pump temperature to achieve the target temperature value using a CO 2 pump heater.
4. The method of claim 1 , wherein the temperature control command is configured to:
cool the CO 2 pump using a coolant; and
adjust the CO 2 pump temperature to achieve the target temperature using a CO 2 pump heater.
5. The method of claim 1 , wherein retrieving the target temperature value includes accessing a lookup table including CO 2 density values as a function of temperature and pressure.
6. The method of claim 1 , further comprising receiving a target mass flow rate at the computing system, and wherein maintaining a constant mass flow rate includes maintaining the target mass flow rate of CO 2 from the CO 2 pump in response to the change in pressure within a CO 2 pump.
7. A system for controlling mass flow rate from a CO 2 pump, the system comprising:
a pressure sensor configured to measure a change in pressure within the CO 2 pump;
a computing system configured execute a temperature control module configured to:
receive a new pressure measurement from the pressure sensor;
retrieve a target temperature value corresponding to the new pressure measurement from a database; and
generate a temperature control command configured to control a CO 2 pump heater or cooler in order to achieve the target temperature value at the CO 2 pump; and
the CO 2 pump heater or cooler configured to execute the temperature control command and achieve a target mass flow rate of CO 2 from the CO 2 pump by achieving the target temperature value at the CO 2 pump.
8. The system of claim 7 , wherein the temperature control command is configured to control a temperature of a coolant to the CO 2 pump.
9. The system of claim 7 , wherein the temperature control command is configured to prompt the CO 2 pump heater or cooler to:
pre-cool a solvent within the CO 2 -based chromatography system to a minimum target temperature; and
adjust the CO 2 pump temperature to achieve the target temperature value using a CO 2 pump heater.
10. The system of claim 7 , wherein the temperature control command is configured to prompt the CO 2 pump heater or cooler to:
cool the CO 2 pump using a coolant; and
adjust the CO 2 pump temperature to achieve the target temperature using a CO 2 pump heater.
11. The system of claim 7 , wherein retrieving the target temperature value includes accessing a lookup table including CO 2 density values as a function of temperature and pressure.
12. The system of claim 7 , wherein the temperature control module is further configured to receive a target mass flow rate at the computing system, and wherein maintaining a constant mass flow rate includes maintaining the target mass flow rate of CO 2 from the CO 2 pump in response to the change in pressure within a CO 2 pump.