Composition for preventing hair loss or promoting hair growth
The present invention is about composition for preventing hair loss or promoting hair growth comprising indirubin derivatives; and one or more selected from the group consisting of Euodia daniellii extract, Persicaria hydropiper extract, Hovenia dulcis extract, methyl vanillate, hesperidin and quercitrin; as an active ingredient. In addition, one or more selected from the group consisting of Euodia daniellii extract, Persicaria hydropiper extract, Hovenia dulcis extract, methyl vanillate, hesperidin and quercitrin of the present invention is a natural-derived composition with little toxicity to cells. Indirubin derivatives are stable compounds that have been found to have little toxicity to the human body, and therefore, when used in a mixture thereof, there are advantages in that they do not exhibit adverse effects on the human body, unlike conventional steroid drugs.
1. A method for treating or reducing hair loss, promoting hair generation, or hair growth comprising administering to subject a composition comprising indirubin derivatives as an active ingredient,
wherein the indirubin derivatives are one or more selected from the group consisting of Formula 1 to Formula 4
2. The method for treating or reducing hair loss, promoting hair generation, or hair growth according to claim 1 , wherein the composition further comprises one or more selected from the group consisting of Euodia daniellii extract, Persicaria hydropiper extract, Hovenia dulcis extract, methyl vanillate, hesperidin and quercitrin.
3. The method for treating or reducing hair loss, promoting hair generation, or hair growth according to claim 2 , wherein the extracts are extracted from the stem, leaves, or their pulverized products thereof and mixtures thereof with a solvent selected from the group consisting of water, alcohols having 1 to 4 carbon atoms, DMSO, n-hexane, ethyl acetate and mixed solvents thereof.
4. The method for treating or reducing hair loss, promoting hair generation, or hair growth according to claim 2 , wherein the indirubin derivative and the extract are mixed, the indirubin derivative is included in an amount of 5 to 15 parts by weight based on the dry weight part 10 of the extract, and wherein the indirubin derivative and one or more small molecular compound selected from methyl vanillate, hesperidin and quercitrin are mixed, the indirubin derivative is mixed at a ratio of 1 to 20 moles based on 1 mole of the small molecular compound.
5. The method for treating or reducing hair loss, promoting hair generation, or hair growth according to claim 2 , wherein the composition is emulsion formulation further comprising oil, surfactant and polyethylenglycol, and wherein mixture ratio of the oil:the surfactants:the polyethylene glycol is 0.3-30:1:2-2.5.