IP Library Granted Patent US 11,160,760
Granted Patent B2
US 11,160,760 · App. 13/839,426 · Granted Nov 2, 2021

Soft capsule based on starch and a method and device for the production thereof

Inventors: Rolf Muller (Zurich, CH); Federico Innerebner (Zurich, CH)
Assignee: INNOGEL AG
A61K9/4816A61J3/077A61K9/4833A61K9/4866B29C43/003B29C43/44B29C43/48C08L3/00A61J3/072A61J3/074B29C2043/486B29K2003/00C08L3/02C08L3/04C08L3/08
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Quick Facts
Patent No.
US 11,160,760
App. No.
13/839,426
Granted
Nov 2, 2021
Kind
B2
Abstract

A method for producing starch soft capsules comprises the following steps: preparing a mixture comprising starch, plasticizer and water, wherein more than 50 weight percent of the starch is present in the form of particles of granular starch; shaping the mixture to form a film in a shaping process; solidifying the mixture by increasing the temperature of the mixture during and/or after the shaping process by more than 5° C.; and shaping the film to form a soft capsule. Soft capsules produced by this method have starch particles bonded to one another. A device for performing this method comprises a shaping device to enable shaping of the starch material to form a film, and a heating device to perform a heat treatment to destructure the starch during and/or after the shaping. It comprises a rotary die device.

Claims (9)

1. A soft capsule shell comprising: a) 15 to 55 weight percent of plasticizer; b) >40 weight percent of starch subtracting the plasticizer; c) 0.1-25 weight percent of water of a total weight; d) up to 20 weight percent of thickener, after subtracting the plasticizer; and e) up to 10 weight percent of carrageenan or carrageenans, after subtracting the plasticizer;

wherein the starch of the soft capsule shell comprises at least 30 percent starch particles that are destructured, wherein the destructured starch particles are bonded to one another, wherein the destructured starch particles are insoluble in water and are recovered by sedimentation after dissolving the soft capsule shell in water for 30 min at 70 degrees Celsius, and wherein the starch of the soft capsule shell has a weight-average molecular weight of at least 2,500,000 g/mol.

2. The soft capsule shell of claim 1 wherein said soft capsule shell comprises a matrix of the destructured starch particles bonded to one another.

3. The soft capsule shell of claim 1 wherein the soft capsule has a proportion of at least 35 weight percent solids content, which are recovered after dissolving the soft capsule at 70 degrees Celsius by sedimentation.

4. The soft capsule shell of claim 1 comprising additives and adjuvants.

5. The soft capsule shell of claim 1 wherein the starch of the soft capsule shell has a weight-average molecular weight of at least 3,000,000 g/mol.

6. The soft capsule shell of claim 1 wherein the starch of the soft capsule shell has a weight-average molecular weight of at least 4,000,000 g/mol.

7. A soft capsule shell comprising: a) 15 to 55 weight percent of plasticizer; b) >40 weight percent of starch, after subtracting the plasticizer; c) 0.1-25 weight percent of water of a total weight of the soft capsule shell; d) up to 20 weight percent of thickener, after subtracting the plasticizer; and e) up to 10 weight percent of carrageenan or carrageenans, after subtracting the plasticizer;

wherein said starch of the soft capsule shell comprises starch particles that are destructured, wherein the destructured starch particles are bonded to one another, wherein the destructured starch particles are insoluble in water, wherein the amount of destructured starch particles recovered by sedimentation after dissolving the soft capsule shell in water for 30 min at 70 degrees Celsius, is at least 25% of the dry weight of the soft capsule shell, and wherein the starch of the soft capsule shell has a weight-average molecular weight of at least 2,500,000 g/mol.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 15, 2013
From: MULLER, ROLF; INNEREBNER, FEDERICO
To: INNOGEL AG
Reel/Frame 030019/0559 →
Priority Claims (1)
CH 00324/09 · Mar 3, 2009 · national
Continuity (2)
Continuation 13255072
Related Publication 20130216618A1 · Aug 22, 2013