IP Library › Granted Patent US 11,162,938
Granted Patent B2
US 11,162,938 · App. 16/494,183 · Granted Nov 2, 2021

Membrane carrier, kit for testing liquid sample using same, and manufacturing method thereof

Inventors: Yuto Akiyama (Machida, JP); Kenji Monden (Tokyo, JP)
Assignee: Denka Company Limited
G01N33/543G01N21/78
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Quick Facts
Patent No.
US 11,162,938
App. No.
16/494,183
Granted
Nov 2, 2021
Kind
B2
Abstract

The present invention provides a membrane carrier 3 comprising a flow path 2 , wherein a microstructure is formed at a bottom of the flow path 2 , and a particle to which an antibody or an antigen binds is arranged in at least a part on the flow path, the particle having a diameter of 500 nm or more and 100 μm or less.

Claims (12)

1. A membrane carrier comprising a flow path, and a detection zone for detecting a target substance, wherein

a microstructure is formed at a bottom of the flow path, wherein the microstructure comprises a plurality of convex portions, wherein each of the plurality of convex portions has a height of 10 μm to 500 μm and a bottom diameter of 10 μm to 1,000 μm, and

a label, which comprises a particle to which an antibody or an antigen binds, is arranged in at least a part of the flow path and is able to bind to the target substance and be transported to the detection zone, the particle having a diameter in the range of 500 nm to 100,000 nm, and

a detection substance immobilized on the detection zone, the detection substance able to bind to a compound comprising the target substance bound to the label.

2. The membrane carrier according to claim 1 , wherein an average horizontal distance between adjacent convex portions is at least 3 times the diameter of the particle and is 300 μm or less.

3. The membrane carrier according to claim 1 , wherein the particle is one or more selected from the group consisting of a colored latex particle and a fluorescent latex particle.

4. The membrane carrier according to claim 1 , wherein

the membrane carrier is a membrane carrier for a test kit of detecting a target substance in a liquid sample, and

the antibody and antigen specifically react with a target substance in the liquid sample.

5. The membrane carrier according to claim 1 , wherein the detection zone produces a color change when the target substance is detected.

6. A method for manufacturing a liquid sample test kit, comprising immobilizing a detection substance producing a color change by holding the target substance in the detection zone of the membrane carrier according to claim 5 .

7. A liquid sample test kit comprising the membrane carrier according to claim 1 .

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 16, 2019
From: AKIYAMA, YUTO; MONDEN, KENJI
To: DENKA COMPANY LIMITED
Reel/Frame 050393/0286 →
Priority Claims (1)
JP JP2017-062948 · Mar 28, 2017 · national
Continuity (1)
Related Publication 20200011859A1 · Jan 9, 2020