Systems and methods for photoactivating a photosensitizer applied to an eye
An antimicrobial treatment system comprises a wearable photoactivation device. The wearable photoactivation device includes a body configured to be positioned on a head of a subject over one or more eyes of the subject. The body includes one or more windows or openings that allow the one or more eyes to see through the body. The body includes one or more photoactivating light sources coupled to the body and configured to direct photoactivating light to the one or more eyes according to illumination parameters. The illumination parameters determine a dose of the photoactivating light that activates, according to photochemical kinetic reactions, a photosensitizer applied to the one or more eyes and generates reactive oxygen species that provide an antimicrobial effect in the one or more eyes, without substantially inducing cross-linking activity that produces biomechanical changes in the one or more eyes.
1. A treatment system comprising a wearable photoactivation device including:
a body defining a chamber shaped to be positioned over and enclose one or more eyes of a subject, the body including one or more windows that allow the one or more eyes to see through the body;
one or more photoactivating light sources coupled to the body and configured to direct photoactivating light to the one or more eyes according to illumination parameters, the illumination parameters determining a dose of the photoactivating light that activates, according to photochemical kinetic reactions, a photosensitizer applied to the one or more eyes and generates reactive oxygen species in the one or more eyes; and
an inlet configured to couple the body to an oxygen source, the chamber receiving oxygen from the oxygen source via the inlet to modify oxygen conditions in the chamber, the activation of the photosensitizer depending on the oxygen conditions,
wherein the photosensitizer includes a riboflavin formulation that penetrates to a depth in the one or more eyes, the one or more photoactivating light sources emit ultraviolet light, and the illumination parameters determine the dose of the ultraviolet light that reaches the depth in the one or more eyes.
2. The treatment system of claim 1 , wherein the one or more photoactivating light sources deliver the photoactivating light as at least one of pulses or continuous wave , and the illumination parameters include at least one of wavelength, power, irradiance, intensity, duration, or duty cycle.
3. The treatment system of claim 1 , further comprising a controller including one or more processors and one or more computer readable media, the one or more processors configured to execute instructions from the computer readable media to:
determine the illumination parameters based on a model of the photochemical kinetic reactions; and
operate the one or more photoactivating light sources according to the illumination parameters.
4. The treatment system of claim 1 , wherein the photoactivation device further includes one or more heating elements coupled to the body and configured to generate heat in the chamber according to temperature parameters, the temperature parameters modifying, according to the photochemical kinetic reactions, the activation of the photosensitizer applied to the one or more eyes and the generation of reactive oxygen species in the one or more eyes.
5. The treatment system of claim 4 , further comprising a controller including one or more processors and one or more computer readable media, the one or more processors configured to execute instructions from the computer readable media to:
determine the temperature parameters based on a model of the photochemical kinetic reactions; and
operate the one or more heating elements according to the temperature parameters.
6. The treatment system of claim 1 , wherein the oxygen from the oxygen source modifies a temperature in the chamber according to temperature parameters, the temperature parameters modifying, according to the photochemical kinetic reactions, the activation of the photosensitizer applied to the one or more eyes and the generation of reactive oxygen species in the one or more eyes.
7. The treatment system of claim 6 , further comprising a controller including one or more processors and one or more computer readable media, the one or more processors configured to execute instructions from the computer readable media to:
determine the temperature parameters based on a model of the photochemical kinetic reactions; and
operate the oxygen source according to the temperature parameters.