Alkene compounds as farnesoid x receptor modulators

1. A compound of Formula (I):

or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof; wherein:

X 1 and X 4 are each independently C or N;

X 2 and X 3 are each independently CR 5 , N, NR 6 , O, or S;

Y is CR 7 , or N;

the dashed straight line is an optional covalent bond;

m and n are each independently an integer of 0, 1, or 2; provided that when m and n are both 0, then the optional covalent bond of the dashed line is absent;

f is an integer of 0, 1, 2, or 3;

Z is 6- to 10-membered aryl, 5- to 10-membered heteroaryl, 3- to 10-membered carbocyclyl, or 4- to 10-membered heterocyclyl, wherein the aryl, heteroaryl, carbocyclyl, and heterocyclyl are independently substituted with 0 to 5 R 8 ;

L 1 is a covalent bond, O, S, NR″, S(O) 2 , C 1-3 alkylene, C 1-3 heteroalkylene, C 2-4 alkenylene, C 2-4 alkynylene, aryl, or a 5- to 6-membered heteroaryl containing 1 to 4 heteroatoms independently selected from N, O, and S; wherein the alkylene, heteroalkylene, aryl, and heteroaryl are each independently substituted with 0 to 3 R 11 ;

L 2 is a covalent bond, O, S, NR 18 , C 1-3 alkylene, or C 1-3 heteroalkylene, wherein the alkylene and heteroalkylene are independently substituted with 0 to 3 R 16 ;

R X is -L 3 -R Z ;

L 3 is a covalent bond, a C 1-3 alkylene, or —C(O)NR 12 —CH 2 —, wherein the C 1-3 alkylene is substituted with 0 to 3 R 15 ;

R Z is —CN, —C(O)OR 13 , —C(O)NR 14a R 14b ,

R e is C 1-6 alkyl, C 3-6 cycloalkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, or haloalkoxyalkyl;

each R Y is independently hydrogen, halo, cyano, hydroxyl, amino, C 1-6 alkyl, alkylamino, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, haloalkoxyalkyl, alkoxy, or haloalkoxy; or alternatively two R Y , together with the carbon atoms to which they are attached, form a bridge moiety; and with the proviso that when Y is N and R Y is attached to a carbon atom adjacent to Y, then R Y is not halo, cyano, hydroxyl, amino, alkoxy, or haloalkoxy;

R 1 is C 1-6 alkyl, C 3-5 cycloalkyl, or C 4-6 heterocyclyl, wherein the alkyl and cycloalkyl are substituted with 0 to 3 R 9 ;

R 2 is 6- to 10-membered aryl, 5- to 10-membered heteroaryl, 3- to 10-membered carbocyclyl, or 4- to 10-membered heterocyclyl, wherein the aryl, heteroaryl, carbocyclyl, and heterocyclyl are independently substituted with 0 to 5 R 10 ;

R 3 and R 4 are each independently hydrogen, C 1-6 alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, or haloalkoxyalkyl;

R 5 and R 7 are each independently hydrogen, halo, cyano, hydroxyl, amino, C 1-6 alkyl, alkylamino, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, haloalkoxyalkyl, alkoxy, or haloalkoxy;

R 6 , R 17 and R 18 are each independently is hydrogen, C 1-6 alkyl, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, or haloalkoxyalkyl;

R 8 and R 10 are each independently halo, cyano, hydroxyl, amino, oxo, —OR a , —SR a , ═S, —NR c R c , ═NH, ═N—OH, ═NR a , ═N—OR a , —NO 2 , —S(O) 2 R a , —S(O) 2 NHR b , —S(O) 2 NR c R c , —S(O) 2 OR b , —OS(O) 2 R b , —OS(O) 2 OR b , —P(O)(OR b )(OR b ), —C(O)R b , —C(NR b )R b , —C(O)OR b , —C(O)NR c R c , —C(NR b )NR c R c , —OC(O)R b , —NR b C(O)R b , —OC(O)OR b , —NR b C(O)OR b , —OC(O)NR c R c , —NR b C(O)NR c R c , —NR b C(NR b )R b , —NR b C(NR b )NR c R c , C 1-6 alkyl, C 1-6 haloalkyl, aryl, arylalkyl, heteroaryl, carbocyclyl, or heterocyclyl; wherein the alkyl, aryl, heteroaryl, carbocyclyl, and heterocyclyl, by themselves or as part of another group, are each independently substituted with 0 to 5 R d ;

R b is each independently hydrogen or R a ;

R c is each independently R b or alternatively, the two R c are taken together with the nitrogen atom to which they are bonded form a 4, 5, 6 or 7-membered heterocyclyl;

R d is each independently R a , alkoxy, haloalkoxy, alkylamino, cycloalkylamino, heterocyclylamino, haloalkyl, hydroxyalkyl, aminoalkyl, cycloalkoxy, heterocyclyloxy, haloalkoxy, alkoxyalkoxy, haloalkylamino, alkoxyalkylamino, haloalkoxyalkylamino, arylamino, aralkylamino, aryloxy, aralkyloxy, heteroaryloxy, heteroarylalkyloxy, alkylthio, halo, cyano, hydroxyl, amino, oxo, —OR a , —SR a , ═S, —NR c R c , ═NH, ═N—OH, ═NR a , ═N—OR a , —NO 2 , —S(O) 2 R a , —S(O) 2 NHR b , —S(O) 2 NR c R c , —S(O) 2 OR b , —OS(O) 2 R b , —OS(O) 2 OR b , —P(O)(OR b )(OR b ), —C(O)R b , —C(NR b )R b , —C(O)OR b , —C(O)NR c R c , —C(NR b )NR c R c , —OC(O)R b , NR b C(O)R b ; —OC(O)OR b , —NR b C(O)OR b , —NR b C(O)NR c R c , —NR b C(NR b )R b , or NR b C(NR b )NR c R c ;

R 9 is each independently halo, cyano, hydroxyl, amino, or C 1-6 alkyl;

R 11 and R 16 are each independently halo, oxo, cyano, hydroxyl, amino, C 1-6 alkyl, C 3-6 cycloalkyl, C 4-6 heterocyclyl, alkylamino, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, haloalkoxyalkyl, alkoxy, or haloalkoxy;

R 12 are each independently hydrogen or C 1-4 alkyl;

R 13 is hydrogen, C 1-10 alkyl, or glycosyl;

R 14a and R 14b are each independently hydrogen, C 1-6 alkyl, C 3-6 cycloalkyl, C 4-6 heterocyclyl, alkylamino, haloalkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, haloalkoxyalkyl, alkoxy, or haloalkoxy; and

R 15 are each independently halo, oxo, cyano, hydroxyl, amino, alkyl, alkoxy, or alkylamino; or alternatively, two R 15 , taken together with the atom(s) to which they are attached, form a carbocyclyl or heterocyclyl moiety.

2. The compound of claim 1 , or a tautomer, or a pharmaceutically acceptable salt thereof, which is represented by Formula (Ia):

3. The compound according to claim 1 , or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein the

moiety is

4. The compound according to claim 1 , or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein the

moiety is:

5. The compound according to claim 1 , or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein:

L 1 is a covalent bond, phenyl, thiazolyl, oxadiazolyl, thiadiazolyl, or pyridinyl; and

Z is phenyl or 5- to 10-membered heteroaryl, wherein the phenyl and heteroaryl are independently substituted with 0 to 5 R 8 .

6. The compound according to claim 1 , or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein:

L 3 is a covalent bond or a C 1-2 alkylene, wherein the C 1-2 alkylene is substituted with 0 to 3 R 15 ; and

R Z is —CN, —C(O)OR 13 , —C(O)NR 14a R 14b ,

7. The compound according to claim 1 , or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein:

L 2 is a covalent bond: and

R 2 is phenyl or 6-membered heteroaryl, wherein the phenyl and the heteroaryl are substituted with 0 to 3 R 10 .

8. The compound according to claim 1 , or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein:

the

moiety is

the

moiety is:

L 1 is a covalent bond, phenyl, thiazolyl, oxadiazolyl, thiadiazolyl, or pyridinyl;

Z is 1,5-naphthyridinyl, benzo[d]imidazolyl, benzo[d]isothiazolyl, benzo[d]oxazolyl, benzo[d]thiazolyl, cinnolinyl, imidazo[3,4-a]pyridinyl, indazolyl, indolyl, isoquinolinyl, phenyl, pyrazinyl, pyrazolo[1,5-a]pyridinyl, pyrazolo[4,3-b]pyridinyl, pyrazolyl, pyridazinyl, pyridinyl, pyrimidinyl, pyrrolo[2,1-f]triazinyl, pyrrolo[2,3-b] pyridinyl, pyrrolo[2,3-d]pyrimidinyl, pyrrolo[3,2-b]pyridinyl, quinolinonyl, quinolinyl, quinoxalinyl, thiazolo[5,4-b]pyridinyl, or thiazolyl, each independently substituted with 0 to 2 R 8 ;

R X is —CN, —C(O)OH, —CH 2 C(O)OH, —C(O)NH 2 , —C(O)NHS(O) 2 CH 3 ,

R 1 is cyclopropyl;

R 2 is phenyl or pyridinyl, each independently substituted with 1 to 2 R 10 ;

R 3 is hydrogen;

R 4 is hydrogen or —CH 3 ;

R 8 is each independently F, Cl, —CH 3 , —CH 2 CH 3 , —CH 2 OCH 3 , —CF 3 , —OCH 3 , —OCD 3 , —OCH 2 CH 3 , —CH(CH 3 ) 2 , —OCH 2 CH 2 OCH 3 , —OCHF 2 , —OCH 2 CHF 2 , —CH 2 (cyclopropyl), —O(cyclopropyl), —O(cyclobutyl), —O(difluorocyclobutyl), —O(fluorocyclobutyl), —O(oxetanyl), —O(tetrahydrofuranyl), or —OCH 2 (methoxyphenyl);

L 2 is a covalent bond; and

R 10 is each independently Cl, —CF 3 , or —OCF 3 .

9. The compound of claim 1 or a salt thereof, wherein said compound is:

(E)-6-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl) nicotinic acid (1);

(E)-6-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)-1-methyl-1H-indole-3-carboxylic acid (2);

(Z)-6-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl) nicotinic acid (3);

(E)-2-(4-(1-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)prop-1-en-2-yl)piperidin-1-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid (4);

(E)-6-(4-(1-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)prop-1-en-2-yl)piperidin-1-yl)quinoline-2-carboxylic acid (5);

(E)-2-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)-4-methylpiperidin-1-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid (6);

(E)-6-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)-4-methylpiperidin-1-yl)quinoline-2-carboxylic acid (7);

(E)-2-(6-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid (8);

(E)-6-(6-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)quinoline-2-carboxylic acid (9);

(E)-2-(4-(2-(4-cyclopropyl-1-(2,6-dichlorophenyl)-1H-1,2,3-triazol-5-yl)vinyl)piperidin-1-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid (10);

(E)-6-(4-(2-(4-cyclopropyl-1-(2,6-dichlorophenyl)-1H-pyrazol-5-yl)vinyl)piperidin-1-yl) nicotinic acid (11);

(E)-2-(4-(2-(1-cyclopropyl-4-(2,6-dichlorophenyl)-1H-pyrazol-5-yl)vinyl)piperidin-1-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid (12);

(E)-6-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl) picolinic acid (13);

(E)-2-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid (14);

(Z)-2-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid (15);

(E)-6-(4-(2-(4-cyclopropyl-1-(2,6-dichlorophenyl)-1H-1,2,3-triazol-5-yl)vinyl)piperidin-1-yl)nicotinic acid (16);

(Z)-2-(3-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid (17);

(E)-6-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl) pyridazine-3-carboxylic acid (18);

(E)-2-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)-7-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid (19);

(E)-6-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)-1-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid (20);

(E)-6-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)-5-fluoronicotinic acid (21);

(E)-2-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl) benzo[d]thiazole-6-carboxylic acid (22);

(E)-2-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl) benzo[d]oxazole-5-carboxylic acid (23);

(E)-5-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl) pyrazine-2-carboxylic acid (24);

(E)-2-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl) pyrimidine-5-carboxylic acid (25);

(E)-6-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl) quinoline-2-carboxylic acid (26);

(E)-5-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl) pyrimidine-2-carboxylic acid (27);

(E)-2-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)-1-methyl-1H-benzo[d]imidazole-5-carboxylic acid (28);

(E)-2-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl) pyrrolo[2,1-f][1,2,4]triazine-5-carboxylic acid (29);

(E)-5-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl) picolinic acid (30);

(E)-3-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)-1-methyl-1H-pyrazolo[4,3-b]pyridine-6-carboxylic acid (31);

(E)-2-(4-(2-(4-cyclopropyl-1-(2,6-dichlorophenyl)-1H-pyrazol-5-yl)vinyl)piperidin-1-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid (32);

(E)-2-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl) quinoline-6-carboxylic acid (33);

(E)-6-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)-4-methylpiperidin-1-yl)nicotinic acid (34);

(E)-6-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)-1-methyl-1H-indole-2-carboxylic acid (35);

(E)-2-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl) isonicotinic acid (36);

(E)-7-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl) isoquinoline-3-carboxylic acid (37);

(E)-6-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)-4-(trifluoromethyl)quinoline-2-carboxylic acid (38);

(E)-6-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)-3-(trifluoromethyl)imidazo[1,5-a]pyridine-1-carboxylic acid (39);

(E)-2-(2-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl) pyridin-4-yl)acetic acid (40);

(E)-6-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)-1-methyl-1H-indazole-3-carboxylic acid (41);

(E)-6-(4-(2-(5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)vinyl)piperidin-1-yl) nicotinic acid (42);

(E)-2-(4-(2-(5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid (43);

(E)-6-(4-(2-(5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)-4-(trifluoromethyl)quinoline-2-carboxylic acid (44);

(E)-6-(4-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)-4-(trifluoromethyl)quinoline-2-carboxylic acid (45);

(E)-2-(6-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)benzo[d]thiazole-6-carboxylic acid (46);

(E)-4-(6-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)benzoic acid (47);

(E)-7-(6-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)isoquinoline-3-carboxylic acid (48);

(E)-2-(4-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid (49);

(E)-4-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl) benzonitrile (50);

(E)-4-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)-2-fluorobenzoic acid (51);

(E)-6-(6-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-(trifluoromethyl)quinoline-2-carboxylic acid (52);

(E)-2-chloro-4-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)benzoic acid (53);

(E)-4-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)benzoic acid (54);

(E)-6-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)-2-(trifluoromethyl)nicotinic acid (55);

(E)-4-(2-(1-(4-(1H-tetrazol-5-yl)phenyl)piperidin-4-yl)vinyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole (56);

(E)-4-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)-2-(trifluoromethyl)benzoic acid (57);

(E)-6-(4-(2-(4-cyclopropyl-1-(2,6-dichlorophenyl)-1H-1,2,3-triazol-5-yl)vinyl)piperidin-1-yl)-4-(trifluoromethyl)quinoline-2-carboxylic acid (58);

(E)-1-(4-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl) phenyl)cyclopropane-1-carboxylic acid (59);

(E)-6-(4-(2-(4-cyclopropyl-1-(2,6-dichlorophenyl)-1H-1,2,3-triazol-5-yl)vinyl)piperidin-1-yl)quinoline-2-carboxylic acid (60);

(E)-4-(2-(3-(4-(2H-tetrazol-5-yl)phenyl)-3-azabicyclo[3.1.0]hexan-6-yl)vinyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole (61);

(E)-4-(2-(1-(4-(2H-tetrazol-5-yl)phenyl)piperidin-4-yl)vinyl)-5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazole (62);

(E)-4-(2-(1-(3-(2H-tetrazol-5-yl)phenyl)piperidin-4-yl)vinyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole (63);

(E)-4-(2-(1-(5-(2H-tetrazol-5-yl)pyridin-2-yl)piperidin-4-yl)vinyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole (64);

(E)-4-(2-(3-(2-(1H-tetrazol-5-yl)quinolin-6-yl)-3-azabicyclo[3.1.0]hexan-6-yl)vinyl)-5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazole (65);

(E)-7-(6-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)cinnoline-3-carboxylic acid (66);

(E)-7-(4-(2-(5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)cinnoline-3-carboxylic acid (67);

(E)-6-(6-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1-methyl-1H-indole-3-carboxylic acid (68);

(E)-7-(4-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)piperidin-1-yl) quinoline-3-carboxylic acid (69);

(E)-4-(6-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)benzamide (70);

(E)-4-(6-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-N-(methylsulfonyl)benzamide (71);

(E)-6-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-(trifluoromethyl)quinoline-2-carboxylic acid (72);

(E)-7-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)isoquinoline-3-carboxylic acid (73);

(E)-6-(6-(2-(5-cyclopropyl-3-(2-fluoro-6-(trifluoromethoxy)phenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-(trifluoromethyl)quinoline-2-carboxylic acid (74);

(E)-6-(6-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-(trifluoromethyl)quinoline-2-carboxylic acid (75);

(E)-7-(6-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)isoquinoline-3-carboxylic acid (76);

(E)-2-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid (77);

(E)-2-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)benzo[d]thiazole-6-carboxylic acid (78);

(E)-2-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)quinoline-6-carboxylic acid (79);

(E)-6-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-methoxyquinoline-2-carboxylic acid (80);

(E)-2-(6-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)thiazolo[5,4-b]pyridine-5-carboxylic acid (81);

(E)-6-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)quinoline-2-carboxylic acid (82);

(E)-6-(4-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)piperidin-1-yl)-4-(trifluoromethyl)quinoline-2-carboxylic acid (83);

(E)-6-(4-(2-(3-(3-chloropyridin-4-yl)-5-cyclopropylisoxazol-4-yl)vinyl)piperidin-1-yl)-4-(trifluoromethyl)quinoline-2-carboxylic acid (84);

(E)-2-(4-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)piperidin-1-yl) thiazolo[5,4-b]pyridine-5-carboxylic acid (85);

(E)-2-(6-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)thiazole-5-carboxylic acid (86);

(E)-2-(4-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)piperidin-1-yl) thiazolo[5,4-b]pyridine-5-carboxylic acid (87);

(E)-6-(4-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)piperidin-1-yl)-4-methoxyquinoline-2-carboxylic acid (88);

(E)-6-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1-methyl-1H-indole-3-carboxylic acid (89);

(E)-7-(4-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)isoquinoline-3-carboxylic acid (90);

(E)-6-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-(difluoromethoxy)quinoline-2-carboxylic acid (91);

(E)-6-(4-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)piperidin-1-yl)-4-(difluoromethoxy)quinoline-2-carboxylic acid (92);

(E)-2-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)benzo[d]thiazole-7-carboxylic acid (93);

(E)-6-(4-(2-(5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)-4-methylquinoline-2-carbonitrile (94);

(E)-6-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)benzo[d]isothiazole-3-carboxylic acid (95);

(E)-4-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)benzoic acid (96);

(E)-6-(4-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)pyridin-3-yl)isoxazol-4-yl)vinyl)piperidin-1-yl)-4-(trifluoromethyl)quinoline-2-carboxylic acid (97);

(E)-6-(4-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)pyridin-3-yl)isoxazol-4-yl)vinyl)piperidin-1-yl)-4-(difluoromethoxy)quinoline-2-carboxylic acid (98);

(E)-6-(4-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)-4-(difluoromethoxy)quinoline-2-carboxylic acid (99);

(E)-6-(4-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)-4-methoxyquinoline-2-carboxylic acid (100);

(E)-7-(4-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)piperidin-1-yl) isoquinoline-3-carboxylic acid (101);

(E)-6-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)nicotinic acid (102);

(E)-7-(4-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)pyridin-3-yl)isoxazol-4-yl)vinyl)piperidin-1-yl)isoquinoline-3-carboxylic acid (103);

(E)-6-(4-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)piperidin-1-yl) isoquinoline-1-carboxylic acid (104)

(E)-6-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)isoquinoline-1-carboxylic acid (105);

(E)-6-(4-(2-(5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)vinyl)piperidin-1-yl) isoquinoline-1-carboxylic acid (106);

(E)-6-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)benzo[d]thiazole-2-carboxylic acid (107);

(E)-6-(4-(2-(5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)-4-isopropoxyquinoline-2-carboxylic acid (108);

(E)-6-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-isopropoxyquinoline-2-carboxylic acid (109);

(E)-6-(4-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)pyridin-3-yl)isoxazol-4-yl)vinyl)piperidin-1-yl)-4-isopropoxyquinoline-2-carboxylic acid (110);

(E)-6-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-methylquinoline-2-carboxylic acid (111);

(E)-2-(4-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)piperidin-1-yl)-7-methylthiazolo[5,4-b]pyridine-5-carboxylic acid (112);

(E)-6-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-(2-methoxyethoxy)quinoline-2-carboxylic acid (113);

(E)-2-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-methoxybenzo[d]thiazole-6-carboxylic acid (114);

(E)-7-(4-(2-(5-cyclopropyl-3-(3-(trifluoromethyl)pyridin-2-yl)isoxazol-4-yl)vinyl)piperidin-1-yl)isoquinoline-3-carboxylic acid (115);

(E)-4-(3-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1,2,4-oxadiazol-5-yl)benzoic acid (116);

(E)-3-(3-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1,2,4-oxadiazol-5-yl)benzoic acid (117);

(E)-6-(4-(2-(5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)vinyl)piperidin-1-yl) pyrazolo[1,5-a]pyridine-3-carboxylic acid (118);

(E)-7-(4-(2-(5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)vinyl)piperidin-1-yl)-1-methylisoquinoline-3-carboxylic acid (119);

(E)-6-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-((tetrahydrofuran-3-yl)oxy)quinoline-2-carboxylic acid (120);

(E)-8-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)quinoline-5-carboxylic acid (121);

(E)-7-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1-methoxyisoquinoline-3-carboxylic acid (122);

(E)-3-(3-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1,2,4-oxadiazol-5-yl)-5-(trifluoromethyl)benzoic acid (123);

(E)-2-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-7-methoxythiazolo[5,4-b]pyridine-5-carboxylic acid (124);

(E)-6-(4-(2-(5-cyclopropyl-3-(3-(trifluoromethyl)pyridin-2-yl)isoxazol-4-yl)vinyl)piperidin-1-yl)-4-methoxyquinoline-2-carboxylic acid (125);

(E)-6-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-(oxetan-3-yloxy)quinoline-2-carboxylic acid (126);

6-(6-((E)-2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-(((R)-tetrahydrofuran-3-yl)oxy)quinoline-2-carboxylic acid (127);

6-(6-((E)-2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-(((S)-tetrahydrofuran-3-yl)oxy)quinoline-2-carboxylic acid (128);

(E)-6-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-((4-methoxybenzyl)oxy)quinoline-2-carboxylic acid (129);

(E)-4-cyclobutoxy-6-(6-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)quinoline-2-carboxylic acid (130);

(E)-3-(3-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1,2,4-oxadiazol-5-yl)-5-methoxybenzoic acid (131);

(E)-6-(6-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-methoxyquinoline-2-carboxylic acid (132);

(E)-3-(5-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1,2,4-oxadiazol-3-yl)benzoic acid (133);

(E)-6-(6-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-(oxetan-3-yloxy)quinoline-2-carboxylic acid (134);

(E)-7-(6-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1-methoxyisoquinoline-3-carboxylic acid (135);

(E)-4-cyclobutoxy-6-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)quinoline-2-carboxylic acid (136);

(E)-3-(3-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1,2,4-oxadiazol-5-yl)-5-(oxetan-3-yloxy)benzoic acid (137);

(E)-7-(6-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)quinoxaline-2-carboxylic acid (138);

(E)-2-(6-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-7-methoxythiazolo[5,4-b]pyridine-5-carboxylic acid (139);

(E)-6-(6-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)quinoxaline-2-carboxylic acid (140);

(E)-6-(6-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)pyridin-3-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-methoxyquinoline-2-carboxylic acid (141);

(E)-4-cyclobutoxy-6-(6-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)pyridin-3-yl)isoxazol-4-yl) vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)quinoline-2-carboxylic acid (142);

(E)-6-(6-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)pyridin-3-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-(oxetan-3-yloxy)quinoline-2-carboxylic acid (143);

(E)-6-(6-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)nicotinic acid (144);

(S,E)-6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)pyrrolidin-1-yl)-4-(trifluoromethyl)quinoline-2-carboxylic acid (145);

(R,E)-6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)pyrrolidin-1-yl)-4-(trifluoromethyl)quinoline-2-carboxylic acid (146);

(S,E)-4-cyclobutoxy-6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl) vinyl)pyrrolidin-1-yl)quinoline-2-carboxylic acid (147);

(R,E)-4-cyclobutoxy-6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl) vinyl)pyrrolidin-1-yl)quinoline-2-carboxylic acid (148);

(E)-6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)azetidin-1-yl)-4-isopropoxyquinoline-2-carboxylic acid (149);

(E)-4-cyclobutoxy-6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl) vinyl)azetidin-1-yl)quinoline-2-carboxylic acid (150);

(E)-6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)azetidin-1-yl)-4-(oxetan-3-yloxy)quinoline-2-carboxylic acid (151);

(E)-6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)azetidin-1-yl)-4-(3,3-difluorocyclobutoxy)quinoline-2-carboxylic acid (152);

(E)-2-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)azetidin-1-yl)-7-methoxythiazolo[5,4-b]pyridine-5-carboxylic acid (153);

(E)-6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)azetidin-1-yl)-4-methoxyquinoline-2-carboxylic acid (154);

(E)-3-(3-(6-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)pyridin-3-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1,2,4-oxadiazol-5-yl)-5-methoxybenzoic acid (155);

(E)-6-(6-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)pyridin-3-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-ethoxyquinoline-2-carboxylic acid (156);

6-(6-((E)-2-(5-cyclopropyl-3-(2-(trifluoromethyl)pyridin-3-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-(((R)-tetrahydrofuran-3-yl)oxy)quinoline-2-carboxylic acid (157);

(E)-5-(6-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-3-ethoxypicolinamide (158);

(E)-4-cyclobutoxy-6-(3-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl) azetidin-1-yl)quinoline-2-carboxylic acid (159);

(E)-6-(3-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)azetidin-1-yl)-4-(oxetan-3-yloxy)quinoline-2-carboxylic acid (160);

(E)-6-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)quinoxaline-2-carboxylic acid (161);

(E)-6-(3-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)azetidin-1-yl)-4-(trifluoromethyl)quinoline-2-carboxylic acid (162);

(E)-5-(6-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-3-ethoxypicolinic acid (163);

(E)-4-(3-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1,2,4-oxadiazol-5-yl)-6-methoxypicolinic acid (164);

(E)-3-(3-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1,2,4-oxadiazol-5-yl)-5-methoxybenzoic acid (165);

(E)-6-(3-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)azetidin-1-yl)-4-methoxyquinoline-2-carboxylic acid (166);

(E)-6-(3-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)azetidin-1-yl) quinoxaline-2-carboxylic acid (167);

(E)-3-(3-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1,2,4-oxadiazol-5-yl)-2-methoxybenzoic acid (168);

(E)-6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)pyridin-3-yl)isoxazol-4-yl)vinyl)azetidin-1-yl)-4-methoxyquinoline-2-carboxylic acid (169);

(E)-4-cyclobutoxy-6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)pyridin-3-yl)isoxazol-4-yl) vinyl)azetidin-1-yl)quinoline-2-carboxylic acid (170);

(E)-6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)pyridin-3-yl)isoxazol-4-yl)vinyl)azetidin-1-yl)-4-(methoxymethyl)quinoline-2-carboxylic acid (171);

(E)-6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)azetidin-1-yl)-4-(methoxy-d3)quinoline-2-carboxylic acid (172);

(E)-6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)azetidin-1-yl)-4-methoxy-1,5-naphthyridine-2-carboxylic acid (173);

(E)-6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)pyridin-3-yl)isoxazol-4-yl)vinyl)azetidin-1-yl)-4-(oxetan-3-yloxy)quinoline-2-carboxylic acid (174);

(E)-6-(6-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)pyridin-3-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-methoxy-1,5-naphthyridine-2-carboxylic acid (175);

(E)-5-(3-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1,2,4-oxadiazol-5-yl)-2-methoxybenzoic acid (176);

(E)-4-cyclopropoxy-6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)pyridin-3-yl)isoxazol-4-yl)vinyl)azetidin-1-yl)quinoline-2-carboxylic acid (178);

(E)-7-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (180);

(E)-7-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)azetidin-1-yl)-1-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (181);

(E)-6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)azetidin-1-yl)-4-(2,2-difluoroethoxy)quinoline-2-carboxylic acid (182);

(E)-4-cyclopropoxy-6-(6-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl) vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)quinoline-2-carboxamide (183);

(E)-4-cyclopropoxy-6-(6-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl) vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)quinoline-2-carboxylic acid (184);

6-(6-((E)-2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-((1S,3S)-3-fluorocyclobutoxy)quinoline-2-carboxylic acid (185);

(E)-6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)azetidin-1-yl)-4-(methoxymethyl)quinoline-2-carboxylic acid (186);

6-(3-((E)-2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)azetidin-1-yl)-4-((1S,3S)-3-fluorocyclobutoxy)quinoline-2-carboxylic acid (187);

(R,E)-6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)pyridin-3-yl)isoxazol-4-yl)vinyl)azetidin-1-yl)-4-((tetrahydrofuran-3-yl)oxy)quinoline-2-carboxylic acid (188);

(S,E)-6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)pyridin-3-yl)isoxazol-4-yl)vinyl)azetidin-1-yl)-4-((tetrahydrofuran-3-yl)oxy)quinoline-2-carboxylic acid (189);

(E)-7-(6-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (190);

(E)-6-(6-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-(2,2-difluoroethoxy)quinoline-2-carboxylic acid (191);

(E)-7-(6-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (192);

(S,E)-6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)azetidin-1-yl)-4-((tetrahydrofuran-3-yl)oxy)quinoline-2-carboxylic acid (193);

6-(3-((E)-2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)azetidin-1-yl)-4-((1R,3R)-3-fluorocyclobutoxy)quinoline-2-carboxylic acid (194);

6-(3-((E)-2-(5-cyclopropyl-3-(2-(trifluoromethyl)pyridin-3-yl)isoxazol-4-yl)vinyl)azetidin-1-yl)-4-((1S,3S)-3-fluorocyclobutoxy)quinoline-2-carboxylic acid (195);

(E)-4-cyclopropoxy-6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl) vinyl)azetidin-1-yl)quinoline-2-carboxylic acid (196);

(E)-7-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)azetidin-1-yl)-1-(cyclopropylmethyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (197);

(E)-6-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-8-fluoro-4-methoxyquinoline-2-carboxylic acid (198);

6-(6-((E)-2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-((1R,3R)-3-fluorocyclobutoxy)quinoline-2-carboxylic acid (199);

(E)-6-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-(2,2-difluoroethoxy)quinoline-2-carboxylic acid (200);

(E)-6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)azetidin-1-yl)-1-methyl-1H-indole-3-carboxylic acid (201);

(E)-6-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-(methoxy-d3)quinoline-2-carboxylic acid (202);

6-(6-((E)-2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-((1S,3S)-3-fluorocyclobutoxy)quinoline-2-carboxylic acid (203);

6-(6-((E)-2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-4-((1R,3R)-3-fluorocyclobutoxy)quinoline-2-carboxylic acid (204);

(E)-4′-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)azetidin-1-yl)-[1,1′-biphenyl]-4-carboxylic acid (205);

(E)-6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)vinyl)azetidin-1-yl)-4-methoxyquinoline-2-carboxylic acid (206);

(E)-4′-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)azetidin-1-yl)-[1,1′-biphenyl]-3-carboxylic acid (207);

(E)-3-(2-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)thiazol-4-yl)-5-methoxybenzoic acid (208);

(E)-6-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxylic acid (209);

(E)-3-(3-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1,2,4-thiadiazol-5-yl)-5-methoxybenzoic acid (210);

(E)-6-(6-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxylic acid (211);

(E)-6-(6-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-2-(cyclopropylmethyl)-2H-indazole-3-carboxylic acid (212);

(E)-6-(6-(2-(5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1-(cyclopropylmethyl)-1H-indazole-3-carboxylic acid (213);

(E)-3-(5-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1,2,4-thiadiazol-3-yl)-5-methoxybenzoic acid (214);

(E)-6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)azetidin-1-yl)-8-fluoro-4-methoxyquinoline-2-carboxylic acid (215);

(E)-3-(2-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)thiazol-5-yl)-5-methoxybenzoic acid (216);

(E)-4-cyclopropoxy-6-(3-(2-(3-(2-(trifluoromethoxy)phenyl)-5-(trifluoromethyl)isoxazol-4-yl)vinyl)azetidin-1-yl)quinoline-2-carboxylic acid (217);

(E)-3-(5-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1,3,4-oxadiazol-2-yl)benzoic acid (218);

(E)-4′-(3-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)azetidin-1-yl)-5-methoxy-[1,1′-biphenyl]-3-carboxylic acid (219);

(E)-1-(4-(3-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)azetidin-1-yl) phenyl)-1H-pyrazole-4-carboxylic acid (220);

(E)-3-(5-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)azetidin-1-yl) pyridin-2-yl)-5-methoxybenzoic acid (221);

(E)-3-(6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)azetidin-1-yl) pyridin-3-yl)-5-methoxybenzoic acid (222)

(E)-3-(5-(6-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)-3-azabicyclo[3.1.0]hexan-3-yl)-1,3,4-thiadiazol-2-yl)-5-methoxybenzoic acid (223);

(E)-3-(6-(3-(2-(5-cyclopropyl-3-(3,5-dichloropyridin-4-yl)isoxazol-4-yl)vinyl)azetidin-1-yl) pyridin-3-yl)-5-(trifluoromethyl)benzoic acid (224);

(E)-3-(6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)azetidin-1-yl) pyridin-3-yl)-5-(trifluoromethyl)benzoic acid (225);

(E)-3-(6-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)azetidin-1-yl) pyridin-3-yl)-5-fluorobenzoic acid (226); or

(E)-3-(5-(3-(2-(5-cyclopropyl-3-(2-(trifluoromethyl)phenyl)isoxazol-4-yl)vinyl)azetidin-1-yl) pyridin-2-yl)-5-(trifluoromethyl)benzoic acid (227).

10. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound according to claim 1 , or a pharmaceutically acceptable salt thereof.

11. The compound according to claim 1 or a salt thereof, wherein:

the

moiety is

moiety is:

Z is cyclopropyl, phenyl, pyrazolyl, thiazolyl, pyridinyl, pyridazinyl, pyrazinyl, pyrimidinyl, indolyl, indazolyl, benzo[d]thiazolyl, pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyridinyl, pyrrolo[3,2-b]pyridinyl, benzo[d]oxazolyl, benzo[d]imidazolyl, pyrrolo[2,1-f]triazinyl, pyrazolo[4,3-b]pyridinyl, pyrrolo[2,1-f]triazinyl, pyrazolo[4,3-b]pyridinyl, thiazolo[5,4-b] pyridinyl, benzo[d]isothiazolyl, pyrazolo[1,5-a]pyridinyl, quinolinyl, isoquinolinyl, quinolinonyl, cinnolinyl, quinoxalinyl or 1,5-naphthyridinyl,

L 1 is a covalent bond, phenyl, thiazolyl, oxadiazolyl, or thiadiazolyl;

L 2 is a covalent bond;

L 3 is a covalent bond or —CH 2 —;

R Z is —CN, —C(O)NH 2 , —C(O)NHS(O) 2 CH 3 , or

R 1 is —CF 3 or cyclopropyl;

R 2 is phenyl, pyridinyl, independently substituted with 0 to 5 R 10 ;

R 3 is hydrogen;

R 4 is hydrogen or —CH 3 ;

each R 8 is independently F, Cl, —CH 3 , or —CF 3 ; and

each R 10 is independently Cl, —CH 3 , —CH 2 CH 3 , —CH 2 (cyclopropyl), —CF 3 , —CH 2 OCH 3 , —OCH 3 , —OCD 3 , —OCH 2 CH 3 , —OCH(CH 3 ) 2 , —O(CH(CH 3 ) 2 ), —OCHF 2 , —OCF 3 , —OCH 2 CHF 2 , —OCH 2 CH 2 OCH 3 , —O(cyclopropyl), —O(cyclobutyl), —O(fluorocyclobutyl), —O(difluorocyclobutyl), —O(oxetanyl), —O(tetrahydrofuranyl), or —OCH 2 (methoxphenyl).