Cancer treatment composition
View Patent ↗The present invention relates to anti-cancer compositions based on extracts of a plant from the Mesembryanthemaceae family, in particular Mesembryanthemum tortuosum ( Sceletium tortuosum ), their use in the treatment of cancer, and methods of manufacturing the compositions. The anti-cancer compositions of the present invention include Δ7 mesembrenone.
1. An anti-cancer composition derived from an extract of a plant from the Mesembryanthemaceae family, the anti-cancer composition comprising Δ7 mesembrenone, and one or more of mesembrine and mesembrenone, wherein with respect to the Δ7 mesembrenone and the one or more of mesembrine and mesembrenone in the composition there is at least 50% (w/w) Δ7 mesembrenone, wherein the composition is in the form of a tablet, capsule, or suppository.
2. The composition of claim 1 , wherein the plant is Mesembryanthemum tortuosum.
3. The composition of claim 1 , wherein with respect to the Δ7 mesembrenone and the one or more of mesembrine and mesembrenone, the composition consists essentially of about 68-70% (w/w) Δ7 mesembrenone, about 20% (w/w) mesembrine and about 10% (w/w) mesembrenone.
4. The composition of claim 1 , wherein the Δ7 mesembrenone and the one or more of mesembrine and mesembrenone, together comprise at least 10% of the composition.
5. The anti-cancer composition of claim 1 , wherein the Δ7 mesembrenone has a purity of at least 80%.
6. The anti-cancer composition of claim 1 , having specific cytotoxicity on breast epithelial carcinoma cells (MCF-7).
7. A method of treating cancer comprising administering to a patient in need of such treatment a therapeutically effective amount of the anti-cancer composition of claim 1 .
8. The method of claim 7 , wherein the cancer is breast cancer.
9. A unit dosage form comprising:
about 5 mg to about 70 mg of Δ7 mesembrenone; and either or both of 1.5 mg to about 20 mg mesembrine; and
0.75 mg to about 10 mg mesembrenone,
wherein the unit dosage form is in the form of a tablet, capsule, or suppository.
10. The composition of claim 1 comprising at least about 70% (w/w) Δ7 mesembrenone.
11. The composition of claim 1 , wherein the Δ7 mesembrenone and the one or more of mesembrine and mesembrenone, together comprise at least 20% of the composition.
12. The unit dosage form of claim 9 , comprising:
about 10 mg to about 65 mg of Δ7 mesembrenone; and either or both of 3 mg to about 18.5 mg mesembrine; and
1.5 mg to about 9.5 mg mesembrenone.
13. The unit dosage form of claim 9 , comprising:
about 15 mg to about 60 mg of Δ7 mesembrenone; and either or both of 4 mg to about 17.5 mg mesembrine; and
2 mg to about 9 mg mesembrenone.