Composition and uses thereof
The present invention relates to compositions for inhibiting inflammation. The composition can comprise one or more natural products in the form of a nutraceutical or functional food. The present invention further relates to the combinatorial use of nutritional supplements and nutraceuticals for the prevention and/or treatment of sterile inflammation and conditions associated with sterile inflammation.
1. A composition comprising one or more natural products selected from the group consisting of compounds that can be isolated from plants of the genera Withania present within the concentration range of 3-350 nM; one or more omega-3 fatty acids present within the concentration range of 1340 nM 85 μM, and:
(i) an extract of turmeric present within the concentration range of 99 nM 21 μM; or
(ii) an extract of pepper present within the concentration range of 135 nM-410 μM; or
(iii) an extract of turmeric present within the concentration range of 99 nM-21 μM, and an extract of pepper present within the concentration range of 135 nM-410 μM;
wherein the combination of one or more omega-3 fatty acids, and extracts from Withania , turmeric and/or pepper is a synergistic combination, wherein the synergistic combination is within a low dose range of up to Fa 0.65.
2. The composition of claim 1 , wherein the one or more natural products selected from the group consisting of compounds that can be isolated from plants of the genera Withania , comprises an extract of ashwagandha.
3. The composition of claim 1 , wherein the one or more natural products selected from the group consisting of compounds that can be isolated from plants of the genera Withania , comprises withaferin A.
4. The composition of claim 1 , wherein the one or more omega-3 fatty acids are selected from the group consisting of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA).
5. The composition of claim 4 , wherein the composition comprises docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA).
6. The composition of claim 4 , wherein the composition comprises DHA.
7. The composition of claim 4 , wherein the composition comprises EPA.
8. The composition of claim 1 , further comprising one or more pharmaceutically acceptable carriers, diluents and/or excipients.
9. The composition of claim 1 , wherein the composition is formulated for oral administration.
10. The composition of claim 1 , wherein the composition is in the form of a powder, a liquid solution, a liposomal solution, a suspension, a dispersion, an emulsion, a tablet, a pill or a capsule.
11. A method of protecting a subject from sterile inflammation, the method comprising administering to the subject a therapeutically effective amount of a composition of claim 1 .
12. A method of treating and/or preventing a condition associated with sterile inflammation, the method comprising administering to the subject a therapeutically effective amount of a composition of claim 1 .