Methods of making and using polyphenols complexed with a protein, peptide, amino acid, polysaccaride, disaccharide, or monosaccharide
The present invention a polyphenol complexes with amino acids, peptides, proteins, glycosaminoglycans, polysaccharides, mucopolysaccharide, disaccharides, monosaccharides, amino sugars, glycol-proteins, DNA/RNA oligonucleotides, mRNA, siRNA, antibodiesor other micro- or macro biomolecules.
1. A polyphenol complex comprising
a therapeutically effective amount of one or more polyphenols wherein the therapeutically effective amount of one or more polyphenols is a curcumin; and
one or more complexing agents conjugated to a therapeutically effective amount of one or more polyphenols, wherein the one or more complexing agents are amino sugars, wherein a ratio of one or more polyphenols to amino sugars of between about 1:2 and 1:20.
2. The composition of claim 1 , wherein the therapeutically effective amount of one or more polyphenols are non-covalently conjugated to the complexing agent.
3. The composition of claim 1 , wherein the therapeutically effective amount of one or more polyphenols comprise 2, 3, 4, 5, 6, or more polyphenols.
4. The composition of claim 1 , wherein the one or more complexing agents comprise N-acetylglucosamine, glucosamine sulfate or N-acetylgalactosamine, glucuronic acid, iduronic acid, galactose chondroitin and glucosamine, glycosaminoglycan Chondroitin sulfate or Glucosamine sulfate.
5. A nutraceutical composition comprising
a therapeutically effective amount of one or more polyphenols, wherein the therapeutically effective amount of one or more polyphenols is a curcumin; and
one or more complexing agents conjugated to a therapeutically effective amount of one or more polyphenols, wherein the one or more complexing agents are amino sugars disposed in a pharmaceutically acceptable excipient, diluent, or carrier, wherein a ratio of one or more polyphenols to amino sugars of between about 1:2 and 1:20.
6. The composition of claim 5 , wherein the ratio is between about 1:2, 1:4, 1:10, 1:20.
7. The composition of claim 5 , wherein the one or more complexing agents is conjugated to a therapeutically effective amount of one or more polyphenols with a covalent bond, noncovalent bond, ionic bond, or hydrogen bond.
8. The composition of claim 1 , wherein the ratio is between about 1:2, 1:4, 1:10, 1:20.
9. The composition of claim 1 , wherein the one or more complexing agents is conjugated to a therapeutically effective amount of one or more polyphenols with a covalent bond, non-covalent bond, ionic bond, or hydrogen bond.