Bupropion as a modulator of drug activity
Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.
1. A dosage form comprising:
about 105 mg of bupropion hydrochloride and about 45 mg of dextromethorphan hydrobromide; or
an amount of a bupropion in the free base form or a salt form and an amount of a dextromethorphan in the free base form or a salt form that provides about the same AUC 0-12 of bupropion and about the same AUC 0-12 of dextromethorphan in a human being as administering: about 105 mg of bupropion hydrochloride and about 45 mg of dextromethorphan hydrobromide to the human being.
2. The dosage form of claim 1 , comprising about 105 mg of bupropion hydrochloride and about 45 mg of dextromethorphan hydrobromide.
3. The dosage form of claim 1 , wherein the dextromethorphan is formulated for immediate release.
4. The dosage form of claim 1 , wherein the bupropion is formulated for sustained release.
5. A method of systemically delivering bupropion and dextromethorphan, comprising administering the dosage form of claim 1 to a human being.
6. The method of claim 5 , wherein the dosage form is administered orally.
7. The method of claim 5 , wherein the dosage form is administered once daily.
8. The method of claim 5 , wherein the dosage form is administered twice daily.
9. The method of claim 5 , wherein the dosage form is administered for at least 8 consecutive days.
10. The method of claim 5 , wherein the dosage form is administered for at least 14 consecutive days.
11. The method of claim 5 , wherein the dosage form is administered for at least 30 consecutive days.
12. A dosage form comprising:
about 210 mg of bupropion hydrochloride and about 90 mg of dextromethorphan hydrobromide; or
an amount of a bupropion in the free base form or a salt form and an amount of a dextromethorphan in the free base form or a salt form that provides about the same AUC 0-24 of bupropion and about the same AUC 0-24 of dextromethorphan in a human being as administering: about 210 mg of bupropion hydrochloride and about 90 mg of dextromethorphan hydrobromide to the human being.
13. The dosage form of claim 12 , comprising about 210 mg of bupropion hydrochloride and about 90 mg of dextromethorphan hydrobromide.
14. The dosage form of claim 12 , wherein the dextromethorphan is formulated for immediate release.
15. The dosage form of claim 12 , wherein the bupropion is formulated for sustained release.
16. A method of systemically delivering bupropion and dextromethorphan, comprising administering the dosage form of claim 12 to a human being.
17. The method of claim 16 , wherein the dosage form is administered orally.
18. The method of claim 16 , wherein the dosage form is administered once daily.
19. The method of claim 16 , wherein the dosage form is administered for at least 8 consecutive days.
20. The method of claim 16 , wherein the dosage form is administered for at least 14 consecutive days.
21. The method of claim 16 , wherein the dosage form is administered for at least 30 consecutive days.