Method for evaluating condition of skin dryness
To provide a method for quickly and accurately evaluating a condition of skin dryness and a method for efficiently searching a substance to improve dry skin. A method for evaluating a condition of skin dryness, the method comprising measuring the expression levels of AGR2 and/or AGR3 in skin cells collected from subjects.
1. A method of treating dry skin, the method comprising:
measuring the expression levels of AGR2 and/or AGR3 in skin cells collected from a test subject, wherein the skin cells comprise living subcorneal skin cells;
identifying the test subject as a subject suffering from dry skin when the measured expression levels of AGR2 and/or AGR3 is 50% or less than a reference value 2, wherein said reference value 2 is a mean value of the expression levels of AGR2 and/or AGR3 in living epidermal cells collected from a control group of subjects known to have non-dry skin; and
administering an agent to said identified subject suffering from dry skin, wherein said agent is selected from the group consisting of vitamin D 3 , eucalyptus extract, and macrocarpal.
2. The method according to claim 1 , wherein said subject suffering from dry skin has rough skin caused by skin dryness.
3. The method according to claim 2 , wherein the rough skin caused by skin dryness is selected from the group consisting of, sensitive skin, xeroderma, senile xerosis, ichthyosis and dry eczema.
4. The method according to claim 1 , wherein said subject suffering from dry skin has a measured expression level of AGR2 and/or AGR3 of 30% or less than said reference value 2.
5. The method according to claim 1 , wherein said subject suffering from dry skin has a measured expression level of AGR2 and/or AGR3 of 25% or less than said reference value 2.
6. The method according to claim 1 , wherein said agent is vitamin D 3 .
7. The method according to claim 1 , wherein said agent is eucalyptus extract.
8. The method according to claim 1 , wherein said agent is macrocarpal.