Intermittent measuring of the partial pressure of an analyte in the skin tissue
It is commonly known within the art of cutaneous/transcutaneous blood gas monitoring to warm up the skin of the patient to allow carbon dioxide and oxygen to diffuse easily through the skin. This is especially the case for transcutaneous partial pressure monitoring of oxygen. Heating the skin to 43° C. to 45° C. over several hours or days may cause damage to the skin. In order to avoid or minimize the risk of these damage, it is proposed to monitor the blood gases at a lower temperature with a cutaneous sensor, and intermittently warm up the skin to a temperature of 42° C. or more for a short duration to monitor the transcutaneous partial pressure of oxygen, before lowering the temperature to the lower set point.
1. A method for monitoring a transcutaneous partial pressure of oxygen (tcpO 2 ) at a measuring site of a patient, comprising:
providing a sensor for measuring the tcpO 2 , wherein the sensor comprises a heating element for heating skin of the patient;
securing the sensor to the skin of the patient, such that the sensor defines the measuring site on the patient; and
performing a tcpO 2 measuring cycle repetitively at the measuring site, wherein the tcpO 2 measuring cycle comprises:
heating the site to a first temperature in a range of 35° C. to 42° C. during a first time interval,
after the first time interval, heating the measuring site to a second temperature to thereby permeabilize the skin to oxygen in an outward direction from tissue or blood of the patient to the sensor,
maintaining the second temperature without erythema to the skin of the patient during a second time interval that is shorter than the first time interval,
after the second time interval, measuring the tcpO 2 at the site during a third time interval until consistent tcpO 2 measurements are obtained,
determining a tcpO 2 level in the patient using the consistent tcpO 2 measurements,
reporting the tcpO 2 level in the patient, and
allowing the skin at the measuring site to cool before repeating the tcpO 2 measuring cycle.
2. The method according to claim 1 , further comprising measuring a partial pressure of CO 2 continuously.
3. The method according to claim 2 , wherein the measuring of the partial pressure of CO 2 takes the first and second temperatures into account.
4. The method according to claim 1 , wherein the tcpO 2 measured during the third time interval is displayed at a monitor during a following first time interval of a subsequent tcpO 2 measuring cycle.
5. The method according to claim 1 , wherein the second temperature is at least 41° C.
6. The method according to claim 1 , wherein the second temperature is at least 43° C.
7. The method according to claim 1 , wherein the second time interval is at least 10 minutes.
8. The method according to claim 1 , wherein the third time interval is 5 minutes.