Method of treating psoriasis with anti-IL23 specific antibody
A method of treating psoriasis in a patient previously treated with and determined to be an inadequate responder to an IL-12/23p40 antibody by administering an IL-23 specific antibody, e.g., guselkumab, in a safe and effective amount and the patient achieves PASI75, PASI90, PASI100 or IGA 0 or 1 score as measured 16, 24, 32, 40 and 48 weeks after initial treatment.
1. A method of treating psoriasis in a patient treated with an antibody to IL-12/23p40 and determined to be an inadequate responder to the IL-12/23p40 antibody treatment, comprising:
administering to the patient determined to be an inadequate responder to the IL-12/23p40 antibody treatment, an anti-IL-23 specific antibody in a safe and effective amount at a dose of 100 mg administered in an initial dose, 4 weeks after the initial dose and every 8 weeks after the dose at 4 weeks, wherein the anti-IL-23 specific antibody comprises a light chain variable region comprising the amino acid sequence of SEQ ID NO: 116 and a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 106, and is in a pharmaceutical composition consisting of 100 mg/mL of the anti-IL-23 specific antibody; 7.9% (w/v) sucrose; 4.0 mM Histidine; 6.9 mM L-Histidine monohydrochloride monohydrate; 0.053% (w/v) Polysorbate 80; and water as a diluent.