IP Library Granted Patent US 11,208,628
Granted Patent B2
US 11,208,628 · App. 14/454,196 · Granted Dec 28, 2021

Nanobionic engineering of organelles and photosynthetic organisms

Inventors: Michael S. Strano (Lexington, MA); Juan Pablo Giraldo Gomez (Somerville, MA); Sean Mitchell Faltermeier (Cambridge, MA); Markita P. Landry (Cambridge, MA)
Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
C12N5/04A01H3/00A01H5/00C12N15/8207C12N15/8212C12N15/8214C12N15/8269G01N33/52C12N15/87
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Quick Facts
Patent No.
US 11,208,628
App. No.
14/454,196
Granted
Dec 28, 2021
Kind
B2
Abstract

In one aspect, a composition can include an organelle, and a nanoparticle having a zeta potential of less than −10 mV or greater than 10 mV contained within the organelle. In a preferred embodiment, the organelle can be a chloroplast and the nanoparticle can be a single-walled carbon nanotube associated with a strongly anionic or strongly cationic polymer.

Claims (31)

1. An engineered chloroplast comprising:

a coated nanoparticle having a zeta potential of less than 10 mV or greater than 10 mV and

a lipid layer that surrounds coated nanoparticle in the chloroplast interior, the coated nanoparticle having the ability to passively transport and irreversibly localize within a chloroplast thylakoid membrane within seconds of nanoparticle interaction with the inner and outer lipid bilayer to enhance electron transport rates.

2. The composition of claim 1 , wherein the nanoparticle includes a nanotube.

3. The composition of claim 1 , wherein the nanoparticle includes a carbon nanotube.

4. The composition of claim 1 , wherein the nanoparticle includes a single-walled carbon nanotube.

5. The composition of claim 1 , wherein the nanoparticle includes cerium oxide.

6. The composition of claim 1 , wherein the nanoparticle is conjugated with at least one cerium oxide nanoparticle.

7. The composition of claim 1 , wherein the nanoparticle includes a polymer.

8. The composition of claim 7 , wherein the polymer of the nanoparticle is cross-linked with at least one cerium oxide nanoparticle.

9. The composition of claim 7 , wherein the polymer includes a polynucleotide.

10. The composition of claim 9 , wherein the polynucleotide includes poly(AT).

11. The composition of claim 7 , wherein the polymer includes a polysaccharide.

12. The composition of claim 11 , wherein the polysaccharide is selected from the group consisting of dextran, pectin, hyaluronic acid, chitosan, and hydroxyethylcellulose.

13. The composition of claim 11 , wherein the polysaccharide is chitosan.

14. The composition of claim 7 , wherein the polymer includes poly(acrylic acid).

15. The composition of claim 1 , wherein the nanoparticle is photoluminescent.

16. The composition of claim 1 , wherein the nanoparticle emits near-infrared radiation.

17. The composition of claim 1 , wherein the nanoparticle has a zeta potential of less than 20 mV or greater than 20 mV.

18. The composition of claim 1 , wherein the nanoparticle has a zeta potential of less than −30 mV or greater than 30 mV.

19. The composition of claim 1 , wherein the nanoparticle is photoluminescent and the photoluminescence emission of the photoluminescent nanoparticle is altered by a change in a stimulus within the organelle.

20. The composition of claim 19 , wherein the stimulus is the concentration of an analyte.

21. The composition of claim 20 , wherein the analyte is a reactive oxygen species.

22. The composition of claim 20 , wherein the analyte is nitric oxide.

23. The composition of claim 20 , wherein the analyte is carbon dioxide.

24. The composition of claim 20 , wherein the analyte is adenosine triphosphate.

25. The composition of claim 20 , wherein the analyte is nicotinamide adenine dinucleotide phosphate.

26. The composition of claim 20 , wherein the analyte is oxygen.

27. The composition of claim 19 , wherein the stimulus is the pH of the organelle.

28. The composition of claim 1 , wherein the nanoparticle is a semiconductor.

29. A green plant including the composition of claim 1 .

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 30, 2021
From: STRANO, MICHAEL S.; GIRALDO GOMEZ, JUAN PABLO; FALTERMEIER, SEAN MITCHELL; LANDRY, MARKITA P.
To: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Reel/Frame 057655/0783 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 30, 2021
From: GIRALDO GOMEZ, JUAN PABLO; FALTERMEIER, SEAN MITCHELL; STRANO, MICHAEL S.; LANDRY, MARKITA P.
To: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Reel/Frame 057655/0857 →
Continuity (3)
Provisional Application 61903520 · Nov 13, 2013
Provisional Application 61864166 · Aug 9, 2013
Related Publication 20150047074A1 · Feb 12, 2015