Keratoprosthesis and uses thereof

1. A procedure for implanting a keratoprosthesis in a patient in need thereof, the procedure comprising the steps of:

Providing a keratoprosthesis, wherein said keratoprosthesis comprises:

(a) a transparent central optical core;

(b) an annular peripheral skirt attached to and substantially surrounding a perimeter of said central optical core, said annular peripheral skirt comprising an anterior conjunctiva-contacting surface configured to contact a posterior surface of the conjunctiva of a patient's eye, a posterior sclera-contacting surface configured to contact an anterior surface of the sclera of the patient's eye; and

(c) an extended portion extending axially below a surface formed by the central optical core and annular peripheral skirt, said extended portion sized and configured for anchoring said central optical core in place into a trephined space of a central cornea of a patient's eye;

Performing a 360 degree peritomy in the eye of said patient;

Elevating and dissecting both tenon capsule and conjunctiva from sclera of the eye of said patient;

Performing trephination of central cornea of said patient's eye;

Placing the transparent central optical core of said keratoprosthesis into the trephined space of said patient's central cornea;

Placing the peripheral skirt of said keratoprosthesis under the dissected tenon capsule and conjunctiva of said patient's eye;

Replacing tenon capsule and conjunctiva onto the annular peripheral skirt of the keratoprosthesis;

wherein said annular peripheral skirt comprises at least one porous biocompatible layer having pore size of at least 2 μm; and

wherein said central optical core has a diameter of at least 3 mm; and

wherein said annular peripheral skirt has a width of at least 3 mm and a thickness ranging from about 100 microns to about 2000 microns, wherein the annular peripheral skirt is sized and configured so that it can be placed under the conjunctiva and above sclera of the eye, wherein the width of the annular peripheral skirt extends from attachment to perimeter of central optical core to an outer edge of the annular peripheral skirt.

2. A procedure according to claim 1 , wherein said at least one porous biocompatible layer is a polymeric layer.

3. A procedure according to claim 1 , wherein said at least one porous biocompatible layer is a nonwoven fabric.

4. A procedure according to claim 1 , wherein said at least one porous biocompatible layer comprises nanofibers.

5. A procedure according to claim 1 , wherein said at least one porous biocompatible layer is formed by electrospinning process.

6. A procedure according to claim 1 , wherein the peripheral skirt further comprises a biomolecule or an antibiotic agent.