Agent for overcoming immunosuppression and use thereof
To provide an agent for overcoming immunosuppression which can overcome immunosuppression by regulatory T cells. An agent for overcoming immunosuppression and an inhibitor of FOXP3 function containing an anthracycline antibiotic as an active ingredient.
1. A method for overcoming immunosuppression by regulatory T cells, the method comprising administering to a patient epirubicin or a salt thereof, in a dose range of 0.1 mg/kg to 0.25 mg/kg, wherein the patient has a solid cancer.
2. The method of claim 1 , further comprising another anticancer therapy.
3. The method of claim 2 , wherein the another anticancer therapy is a cancer chemotherapy or a cancer immunotherapy.
4. The method of claim 3 , wherein the another anticancer therapy is a cancer immunotherapy selected from the group consisting of an immune checkpoint blockade therapy, a cancer vaccine therapy, and a T cell transfer therapy.