IP Library Granted Patent US 11,213,554
Granted Patent B2
US 11,213,554 · App. 16/762,278 · Granted Jan 4, 2022

Composition for improving the health of livestock

Inventors: Michel Layus (Pleumeur Bodou, FR); Alexandre Brame (Rennes, FR)
Assignee: NOLIVADE
A61K35/744A61K9/06A61P31/04
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Quick Facts
Patent No.
US 11,213,554
App. No.
16/762,278
Granted
Jan 4, 2022
Kind
B2
Abstract

A method for the prevention or treatment of infections contracted by newborns of livestock mammals, which includes applying a composition that includes a mixture of bacterial strains to the perineum and/or the teat(s) of female livestock mammal that is going to give birth or has given birth to the newborn livestock mammals. Also, a kit for preventing digestive, respiratory or other infections in newborn livestock mammals, which includes at least one composition and at least one application element for applying the composition to the perineum and/or to the teats of the female livestock mammals.

Claims (18)

1. A method for prevention or treatment of infections contracted by a newborn livestock mammal at the time of birth, said method comprising a step of applying a composition to the perineum and/or to the teats of the female that is going to give birth or has given birth to said newborn livestock mammals, before and/or after parturition,

wherein the composition comprises or consists essentially of a mixture of:

three Bacillus subtilis strains: NOL01, NOL02, NOL03, said Bacillus subtilis strains being deposited in the CNCM under the numbers: CNCM I-4606, CNCM I-5043 and CNCM I-4607, respectively, and

a lactic acid bacteria strain: Lactococcus lactis spp lactis 1 strain NOL11, said strain being deposited in the CNCM under number CNCM I-4609.

2. The method according to claim 1 , wherein the composition comprises 10 4 to 10 11 bacterial colonies of said Bacillus subtilis strains and 10 4 to 10 11 bacterial colonies of said lactic bacteria strain, the bacterial colonies being per ml or g of composition.

3. The method according to claim 1 , wherein said Bacillus subtilis strains are in sporulated and/or vegetative form.

4. The method according to claim 1 , wherein said female is in an environment previously treated with the composition.

5. The method according to claim 1 , wherein said infections are intestinal infections.

6. The method according to claim 1 , wherein said infections are selected from the group consisting of neonatal diarrhea, enteritis, salmonella , rhinitis, pasteurellosis, bordetellose, ulcers, epidermitis, necroses, and infectious lameness.

7. The method according to claim 1 , wherein said infections are intestinal infections, and wherein said composition is applied to the perineum and/or the teat(s) by spraying, spreading, powdering or soaking.

8. The method according to claim 1 , wherein said infections are neonatal diarrhea.

9. The method according to claim 1 , wherein said infections are ear necrosis, rhinitis and arthritis.

10. A kit for preventing digestive, respiratory or other infections in newborn livestock mammals, substantially comprising:

at least a composition comprising or consisting essentially of a mixture of:

three Bacillus subtilis strains: NOL01, NOL02, NOL03, said Bacillus subtilis strains being deposited in the CNCM under the numbers: CNCM I-4606, CNCM I-5043 and CNCM I-4607, respectively, and

a lactic acid bacteria strain: Lactococcus lactis spp lactis 1 strain NOL11, said strain being deposited in the CNCM under number CNCM I-4609,

and

at least one application means for applying said composition to the perineum and/or to the teats of the female that is going to give birth or has given birth to said newborn livestock mammals.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 15, 2022
From: NOLIVADE
To: MIXSCIENCE
Reel/Frame 059608/0132 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 2, 2020
From: LAYUS, MICHEL; BRAME, ALEXANDRE
To: NOLIVADE
Reel/Frame 052806/0911 →
Priority Claims (1)
FR 1760496 · Nov 8, 2017 · national
Continuity (1)
Related Publication 20200353019A1 · Nov 12, 2020