Frictional trans-epithelial tissue disruption collection apparatus and method of inducing an immune response

1. A fabric for abrading epithelial surfaces and collecting a histological tissue sample comprising:

a backing-material;

a plurality of curved fenestrated loops comprising a short hook end and a first length attached to the backing material, where each curved fenestrated loop of the plurality of curved fenestrated loops is formed from each cut of a plurality of cuts on each loop of a plurality of loops at a distal location from the backing material, generating the curved fenestrated loop, where the first length is the distance from the top of the plurality of curved fenestrated loops to the backing material, where the plurality of curved fenestrated loops are arranged to form one or more channels, where the plurality of curved fenestrated loops have sufficient flexibility and rigidity to frictionally abrade an epithelial surface, where the first length is between 3 mm and 25 mm, where a distance from the top of the plurality of curved fenestrated loops to the bottom of the short hook end is less than twenty (20) percent of the first length, where rotation of the fabric pressed against the epithelial surface is adapted to abrade the epithelial surface with the short hook end adapted to release the histological tissue sample; and

a plurality of curved short arms with a second length attached to the backing material, where the second length is less than the first length, where the plurality of curved short arms are formed from the plurality of cuts on the plurality of loops, where each curved short arm of the plurality of curved short arms is adjacent to each curved fenestrated loop of the plurality of curved fenestrated loops, where the histological tissue sample is adapted to collect in the plurality of curved short arms, where the plurality of curved fenestrated loops do not fracture or separate under moderate pressure, where under applied pressure when the fabric is pressed and rotated against the epithelial surface the short hook end of the plurality of curved fenestrated loops is adapted to splay and separate from the curved short arms thereby opening a collection well to collect the histological tissue sample.

2. The fabric of claim 1 , where the backing material is adapted to be applied to a flexible platform.

3. The fabric of claim 1 , where the short hook end is oriented towards the backing material.

4. The fabric of claim 1 , where the plurality of curved fenestrated loops are made of plastic.

5. The fabric of claim 1 , where the plurality of curved fenestrated loops are made of nylon.

6. A fabric for removing and collecting a histological tissue sample from an epithelial surface comprising:

a backing material;

a plurality of curved fenestrated loops attached to the backing material each with a first length and including a short hook end, where the plurality of curved fenestrated loops have sufficient flexibility and rigidity to remove, collect and store the histological tissue sample from the epithelial surface, where the first length is between 3 mm and 25 mm, where a distance from the top of the plurality of curved fenestrated loops to the bottom of the short hook end is less than 20% of the first length of the plurality of curved fenestrated loops, where rotation of the fabric pressed against the epithelial surface is adapted to abrade the epithelial surface with the short hook end adapted to release the histological tissue sample; and

a plurality of curved short arms with a second length attached to the backing material, where the second length is less than the first length, where each curved short arm of the plurality of curved short arms is adjacent to each curved fenestrated loop of the plurality of curved fenestrated loops, where the curved fenestrated loops do not separate under minimal pressure, where under applied pressure when the fabric is pressed against the epithelial surface the short hook end of the plurality of curved fenestrated loops further separate from the curved short arms thereby providing a collection well formed between the curved short arms and the curved fenestrated loops for the histological tissue sample.

7. The fabric of claim 6 , where the backing material is adapted to be applied to a flexible platform.

8. The fabric of claim 6 , where the backing material is adapted to adhere to a rigid platform.

9. The fabric of claim 6 , where the short hook end is oriented towards the backing material.

10. The fabric of claim 6 , where the short hook end orients towards the epithelial surface under pressure.

11. The fabric of claim 6 , where the short hook end under pressure applies frictional forces to the epithelial surface to excoriate the histological tissue sample.

12. The fabric of claim 6 , where the backing material is adapted to be cut into uniform shapes.

13. A method for removing and collecting a histological tissue sample from an epithelial surface comprising:

receiving a fabric attached to a platform, where the fabric includes a backing material adapted to be adhered to the platform and a plurality of curved fenestrated loops attached to the backing material having a length and sufficient flexibility and rigidity to remove and collect the histological tissue sample from the epithelial surface, where each of the plurality of curved fenestrated loops includes a short hook end, where the length is between 3 mm and 25 mm, where a distance from the top of the plurality of curved fenestrated loops to the bottom of the short hook end is less than 20% of the length of the plurality of curved fenestrated loops, where the fabric includes a plurality of curved short arms, where each curved fenestrated loop of the plurality of curved fenestrated loops is formed from each cut of a plurality of cuts at a distal location from the backing material generating the short hook end, where each curved short arm of the plurality of curved short arms is formed from each cut of the plurality of cuts at the distal location, where each curved short arm of the plurality of curved short arms is adjacent to each curved fenestrated loop of the plurality of curved fenestrated loops, where the fenestrated loops do not fracture under minimal pressure, where under pressure when the fabric is pressed against the epithelial surface, the short hook end of the plurality of curved fenestrated loops separates from the curved short arms;

contacting the fabric to the epithelial surface;

applying pressure to the fabric in contact with the epithelial surface; and

rotating the platform clockwise and counterclockwise, where one or more short hook ends abrades the epithelial surface when rotated releasing the histological tissue sample, where the plurality of curved fenestrated loops and curved short arms collect the histological tissue sample.

14. The method of claim 13 , where the short hook end applies frictional forces to the epithelial surface to excoriate the histological tissue sample under pressure.