IP Library › Granted Patent US 11,243,208
Granted Patent B2
US 11,243,208 · App. 16/317,184 · Granted Feb 8, 2022

Autoantibody biomarkers for the early detection of ovarian cancer

Inventors: Benjamin Katchman (Tempe, AZ); Karen Anderson (Scottsdale, AZ); Garrick Wallstrom (Mesa, AZ); Joshua LaBaer (Chandler, AZ); Daniel Cramer (Chestnut Hill, MA)
Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY; THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
G01N33/57449G01N2800/60
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Quick Facts
Patent No.
US 11,243,208
App. No.
16/317,184
Granted
Feb 8, 2022
Kind
B2
Abstract

Compositions and methods relating to a panel of antigen biomarkers for the early detection of ovarian cancer. The compositions and methods encompass antigen biomarkers coupled to a substrate, with the biomarkers being selected from the group consisting of one or more of ICAM3, CTAG2, p53, STYXL1, PVR, POMC, NUDT11, TRIM39, UHMK1, KSR1, and NXF3.

Claims (3)

1. A composition comprising a panel of antigen biomarkers for the early detection of ovarian cancer coupled to a substrate, wherein the substrate comprises a solid support, wherein said biomarkers consist of cancer/testis antigen 2 (CTAG2), cellular tumor antigen p53 (p53), poliovirus receptor (PVR), diphosphoinositol polyphosphate phosphohydrolase 3-beta (NUDT11), intercellular adhesion molecule 3 (ICAM3), E3 ubiquitin-protein ligase TRIM39 (TRIM39), serine/threonine/tyrosine-interacting-like protein 1 (STYXL1), Pro-opiomelanocortin (POMC), serine/threonine-protein kinase Kist (UHMK1), kinase suppressor of Ras 1 (KSR1), and nuclear RNA export factor 3 (NXF3).

2. A diagnostic test kit for ovarian cancer, comprising (1) the composition of claim 1 , and (2) a detection reagent.

3. The composition of claim 1 , wherein the solid support comprises a 96 well plate.

Assignments (3)
LICENSE Recorded Aug 25, 2025
From: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 072570/0113 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 24, 2019
From: KATCHMAN, BENJAMIN; ANDERSON, KAREN; WALLSTROM, GARRICK; LABAER, JOSHUA
To: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
Reel/Frame 048119/0332 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 24, 2019
From: CRAMER, DANIEL
To: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
Reel/Frame 048119/0476 →
Continuity (2)
Provisional Application 62360817 · Jul 11, 2016
Related Publication 20190302122A1 · Oct 3, 2019
Cited By (1)
US 12,196,757